The Hypoglycemic and Antioxidant Activity of Cress Seed and Cinnamon on Streptozotocin Induced Diabetes in Male Rats

Abstract

The present study aimed to estimate the stimulation of pancreas of rats with streptozotocin induced diabetes using 20% (w/w) garden cress seed (Lepidium sativum) and cinnamon methanol extracts. The positive control diabetic group showed a significant increase in fasting blood sugar, lipid peroxide, interleukin-6, carboxymethyl lysine, serum uric acid, urea, creatinine, immunoglobulins, and urine albumin and a significant decrease in antioxidant enzymes, sodium ions, potassium ions, and urine creatinine. Severe histopathological changes in the kidney and pancreas tissues in hyperglycemic rats were also shown in the positive control diabetic group. Meanwhile, the groups that were treated with 20% garden cress seed and cinnamon methanol extracts showed a significant decrease in fasting blood sugar and all elevated abovementioned biochemical parameters and an increase in the lowered ones restoring them nearly to the normal levels of G1. Kidney and pancreas tissues were also ameliorated and restored nearly to the normal status. Both garden cress seed and cinnamon methanol extracts succeeded in controlling hyperglycemia in rats with streptozotocin induced diabetes and ameliorated the biochemical and histopathological changes because of their antioxidant activity acquired by their possession of phenolic phytochemicals.

Salvadora persica leaf aqueous extract attenuates hyperglycemia and hyperlipidemia in alloxan induced diabetic male rats

“…The serum alpha-amylase which is considered as an indication of proper pancreatic function [39,40] was also decreased as a result of diabetes and nearly restored its normal levels by treating with S. persica leaf aqueous extract. In addition, the immunoglobulin's (IgG, IgA and IgM) levels were increased by diabetes [38,41] and they were decreased with the administration of the aqueous extract of S. persica to the alloxan induced diabetic rats in G3 and G4 for 4 weeks. This result is consistent with recent studies by Deepti et al [42] who reported that there was a positive correlation between the two parameters elevated HbA1c and Immunoglobulin level.…”

Ameliorative Effect of Garden Cress (Lepidium sativum L.) Seeds Ethanolic Extract on High Fat Diet-prompted Non-alcoholic Fatty Liver Disease in the Rat Model: Impact on 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase and Vascular Endothelial Growth Facto

“…Feeding GC seed oil supplementation for 60 days than natural oil in rats, Umesha and Naidu (2015) reported higher levels of hepatic tocopherols, catalase, and glutathione peroxidase activity. Following oral supplementation of 20%GC methanol seed extract (w/v) for 28 days in streptozotocin-induced diabetic rats, Qusti et al (2016) observed an increased renal and pancreatic activity of SOD, CAT, GSH, and a decreased MDA contents. A pre-exposure of GC seeds extract (25 µg/ ml) showed cytoprotective effects against H 2 O 2 -induced toxicity in HepG2 (Al-Sheddi et al, 2016).…”

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“…Various researchers worked on various extracts of the plant to prove huge pharmacological properties. It is having anti-diabetic property 4,5 , anti-diarrheal property 6 , anti-oxidant activity 7 , gonadotropin secretion property 8 , anti-cholesterol property 9 , hypothyroid property 10 , anti-hepatitis activity 11 , Immunostimulant property 12 , hepatoprotective property 13,14 , fracture healing property, antihypertensive, diuretic, hepatoprotective, nephrocurative, nephroprotective activity, anticancer activity, bronchoprotective, galactagogue property, analgesic, anti-inflammatory, anti-pyretic and antimicrobial activity 15,16,17 .…”