Salvadora persica leaf aqueous extract attenuates hyperglycemia and hyperlipidemia in alloxan induced diabetic male rats

Abstract

Background: Herbal medicine has been widely used in controlling diabetes and obesity for avoiding their complications. Objectives: The anti-diabetic, antioxidant and anti-lipidemic activity of Salvadora persica leaf aqueous

The antioxidant and antidiabetic activity of the Arabian balsam tree “Commiphora gileadensis” in hyperlipidaemic male rats

“…In the present study, the alloxan-induced diabetes in the hypercholesterolemic rats occurs via a series of correlated events in the pancreatic beta cells, started with the injury of beta cells by the accumulation of alloxan followed by generation ROS with its reduction product, dialuric acid and finally the autoxidation of the dialuric acid that generates superoxide radicals, hydrogen peroxide and hydroxyl radicals that lead to the death of these beta cells [12,27,44,45]. The pancreatic beta cells are characterized by their low antioxidative defence capacity that leads to their death and the insulin-dependent alloxan diabetes [44,45].…”

“…Nowadays, therapeutic dietary nutrition and numerous plant natural products can assist the mechanisms of body homeostasis and protect or ameliorate metabolic syndrome [9]. Several herbal extracts and natural products have proved highly effective in the treatment of both diabetes and hyperlipidaemia [9][10][11][12]. In addition, Lachin and Reza [13] reported that cherries protect against alloxan-induced diabetes.…”

“…Balasubramanian et al [15] also reported that Stereospermum suavelolens ameliorates diabetic nephropathy. El Rabey et al [16,17], Al-Seeni et al [18] and Abulnaja and El Rabey [19] used natural products in lowering hyperlipidaemia. Al-Malki and El Rabey [20] used Moringa oleifera in controlling streptozotocin-induced diabetes, whereas Qusti et al [21] stated that cinnamon and cress seed can control diabetes in male rats.…”

Free Radical Scavenging and Antioxidant Potential of Ethanolic Leaf Extract of Diodia sarmentosa on High Fat Fed Wistar Rats

“…Groups LDE, HDE and SAD significantly reduced (p<0.05) lipid peroxidation expressed as malondialdehyde levels, thus reversing the cellular damage caused by oxidative stress. The efficacy of Diodia sarmentosa is similar to that of Salvadora persica in the reduction of lipid peroxidation (MDA activity) [35].…”

“…This increase in the antioxidant enzyme superoxide dismutase, reduced superoxide radicals by the dismutation of superoxide radical to form hydrogen peroxide and oxygen. The efficacy of Diodia sarmentosa in the increase of SOD activity can be likened to the efficacy of Salvadora persica in the increase of Superoxide dismutase activity in alloxan induced diabetic rats [35].…”