Protective and curative effects of Cestrum nocturnum on rabbit kidney

Abstract

<p class="Abstract">The objective of current study was to evaluate the nephroprotective and nephrocurative effects of methanolic extract of <em>Cestrum nocturnum</em> leaves in rabbits. Gentamicin (80 mg/kg/day) was administered intramuscularly to induce nephrotoxicity. The induction was assessed by biochemical and histopathological analysis. Methanolic extract (100, 300 or 500 mg/kg) was given orally with gentamicin for 25 days in nephroprotective study whereas in nephrocurative study, gentamicin was administered intramuscularly for first 10 days and for next 15 days only methanolic extract (100, 300 or 500 mg/kg, orally) was administered. A significant decrease was found in total oxidant status, blood urea nitrogen, serum creatinine and uric acid levels whereas albumin level increased significantly. Histopathological studies also revealed nephroprotective and nephrocurative effects. In conclusion, the methanolic extract of <em>C. nocturnum</em> leaves exhibited significant nephro-protective and nephrocurative effects in experimental animal.</p><p class="Abstract"><strong>Video Clip of Methodology</strong>:</p><p class="Abstract">6 min 47 sec: <a href="https://www.youtube.com/v/-IavmdW6RF8">Full Screen</a> <a href="https://www.youtube.com/watch?v=-IavmdW6RF8">Alternate</a></p><p class="Abstract"> </p>

Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

“…More interest has developed to the protective effects of medicinal plants against chemically induced toxicities (Frei and Higdon, 2003). For example, Azima tetracantha (Konda et al, 2016) and Capparis spinosa (Tlili et al, 2017), Cestrum nocturnum (Saleem et al, 2017), Morus alba (Ullah et al, 2016), Nigella sativa (Begum et al, 2006), Sechium edule (Mumtaz et al, 2012), Terminalia muelleri (Fahmy et al, 2016) show nephroprotective effect.…”

Biologically Active Saponins of Genus Cestrum L.: A Comprehensive Review

“…In the traditional Indian ayurvedic medicine, C. diurnum L. is used for the enhancement of calcium levels in the body [6]. C. nocturnum L. is being used in the folkloric Pakstinian therapy for the treatment of gastric ulcer [7]. Its efficacy in burn healing has been reported in Chinese folk medicine [8].…”