Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

Pervez, Samreen; Saeed, Muhammad; Khan, Haroon; Shahid, Muhammad; Ullah, Irfan

doi:10.3329/bjp.v13i3.36621

Cited by 10 publications

(6 citation statements)

References 39 publications

(40 reference statements)

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“…This shows that herbal compounds of C. pictus offered considerable protection to the kidney tissues. Similar nephroprotective effect of herbal plants against gentamicin toxicity have been reported (Pervez et al, 2018).…”

Section: Discussionsupporting

confidence: 82%

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Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat

Rajasekaran

2019

Bangladesh J Pharmacol

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The present study was conducted to evaluate the nephroprotective effect of a medicinal herb Costus pictus against doxorubicin-induced toxicity. Rats were divided into six groups and treated with doxorubicin and ethanol extract of the C. pictus. Doxorubicin was administered intraperitoneally with a single dose (4 mg/kg) per week for three weeks. The extract (200 or 400 mg/kg) was administered orally for 4 weeks to two doxorubicin groups. Significant changes of the serum kidney markers, albumin, urea, uric acid and creatinine, and glutathione peroxidase, glutathione–S-transferase, catalase, superoxide dismutase, reduced glutathione and lipid peroxides in the kidney of doxorubicin-treated rat were observed. Histological features were also severely affected. However, biochemical and histological changes in the extract-treated rat were non-significant, showing that the herb is nephroprotective. The effects were comparable to the anti-oxidant vitamin E.

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Section: Discussionsupporting

confidence: 82%

“…Reference Pervez et al, 2018;Zaware et al, 2018 orally for four weeks. Group V was administered with doxorubicin (4 mg/kg/week for three weeks i.p.)…”

Section: Wax Blocks Were Trimmed For Sectioningmentioning

confidence: 99%

Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat

Rajasekaran

2019

Bangladesh J Pharmacol

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“…Local communities use B. balochistanica against different diseases as a beneficial herbal agent to cure cough, purify blood, microbial infection, toothache, high blood pressure, diabetes, snake and insect bites, internal injuries of human beings and livestock (Bibi et al, 2014; Zaidi et al 2012; Baloch et al, 2013). Further, B. balochistanica has been extensively studied for phytochemical and biological purposes, such as gentamicin‐induced renal toxicity, antimicrobial and insecticidal activity, food preservative, cancer mortality, and coronary heart diseases (Pervez et al, 2018; Kakar et al, 2012; Abbasi et al, 2013; Baloch et al, 2013; Batool et al, 2019). This endemic plant is rich source of secondary metabolites such as flavonoids, alkaloids, vitamins, phenols, and carotenoids (Baloch et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of nickel oxide nanoparticles using leaf extract of Berberis balochistanica: Characterization, and diverse biological applications

Uddin

Safdar

Iqbal

et al. 2021

Microscopy Res & Technique

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In current report, nickel oxide nanoparticles (NiONPs) were synthesized using leaf extract of Berberis balochistanica (BB) an endemic medicinal plant. The BB leaves extract act as a strong reducing, stabilizing, and capping agent in the synthesis of BB@NiONPs. Further, BB@NiONPs were characterized using Uv–visible spectroscopy (UV–vis), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR), Energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and average size was calculated ~21.7 nm). Multiple in vitro biological activities were performed to determine their therapeutic potentials. The BB@NiONPs showed strong antioxidant activities in term of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and total antioxidant capacity (TAC) with scavenging potential of 69.98 and 59.59% at 200 μg/ml, respectively. The antibacterial and antifungal testes were examined using different bacterial and fungal strains and dose‐dependent inhibition response was reported. Laterally, cytotoxic and phytotoxic activities were studied using brine shrimp and radish seeds. The result determined potential cytotoxic activity with LD50 value (49.10 μg/ml) and outstanding stimulatory effect of BB@NiONPs on seed germination at lower concentrations as compared to control. Overall, result concluded that biosynthesis of NiONPs using leaf extracts of Berberis balochistanica is cheap, easy, and safe method and could be used in biomedical and agriculture field as nanomedicine and nano fertilizer.

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“…Tissues were dehydrated in ascending grades of ethanol, cleared with xylene and embedded in paraffin. After making thin slices (3-5m), samples were stained by Hematoxylin and Eosin (H&E) and photographs were taken by using a camera fitted microscope (22).…”

Section: Histopathologymentioning

confidence: 99%

The hematological and histological studies for the hepatoprotective-like effect of the hydromethanolic extract and the fractions of Viola serpens Wall.

Ghaffar

Ahmad

Khan

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Traditionally, Viola serpens has been used in the treatment of several human disorders including liver diseases without any scientific evidence. As the current therapies are not very effective and face challenges of unwanted effects and patient compliance, therefore more effective and safe agents are highly needed. The current study aimed to evaluate the hepatoprotective potential of the crude extract and subsequent fractions of the whole plant in the in-vivo model using various hematological and histopathological parameters followed by an HPLC study for the identification of phenolic compounds. Rabbits (1000-1200 g) were used in the study. Paracetamol (2g) was used to induce hepatotoxicity in experimental rabbits. The plant extract was used in two doses (150 and 300 mg/kg body weights) for eight days. The hematological parameters AST, ALT and ALP values were determined along with the histopathology of the liver. Phenolic compounds were identified by high-performance liquid chromatography (HPLC) Agilent-1260 infinity from their retention time, UV spectra and available standards while quantification was done taking the percent peak area. The doses 150 and 300 mg/kg body weight seemed to be more effective. The hematological values and the histopathological slides show the hepatoprotective effect of the plant. Regeneration indicated the presence of nuclei, nuclear cleaning, prominent nucleoli, RBC’s, central veins and plates of hepatocytes. The HPLC studies revealed the presence of a number of phenicol compounds. The crude extract and the subsequent fractions of the plant possess strong hepatoprotective activity, providing a scientific rationale for its uses in the treatment of liver toxicities.

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Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

Cited by 10 publications

References 39 publications

Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat

Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat

Green synthesis of nickel oxide nanoparticles using leaf extract of Berberis balochistanica: Characterization, and diverse biological applications

The hematological and histological studies for the hepatoprotective-like effect of the hydromethanolic extract and the fractions of Viola serpens Wall.

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