Binding of Plant Polyphenols to Serum Albumin and LDL: Healthy Implications for Heart Disease

Poloni, Dana M.; Dangles, Olivier; Vinson, Joe A.

doi:10.1021/acs.jafc.8b06674

Cited by 33 publications

(32 citation statements)

References 54 publications

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“…Poloni et al [174] carried out a systematic investigation comparing the binding of 41 plant polyphenols, which bear potent antioxidant properties, to serum albumin and LDL isolated from pigs. By monitoring quenching of intrinsic fluorescence of albumin and apoB-100 on LDL following addition of polyphenols, they reported that the calculated quenching constant and binding were in general higher for albumin compared to LDL.…”

Section: Antioxidant Anti-inflammatory and Anti-atherogenic Agentsmentioning

confidence: 99%

Reconfiguring Nature’s Cholesterol Accepting Lipoproteins as Nanoparticle Platforms for Transport and Delivery of Therapeutic and Imaging Agents

2020

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Apolipoproteins are critical structural and functional components of lipoproteins, which are large supramolecular assemblies composed predominantly of lipids and proteins, and other biomolecules such as nucleic acids. A signature feature of apolipoproteins is the preponderance of amphipathic α-helical motifs that dictate their ability to make extensive non-covalent inter- or intra-molecular helix–helix interactions in lipid-free states or helix–lipid interactions with hydrophobic biomolecules in lipid-associated states. This review focuses on the latter ability of apolipoproteins, which has been capitalized on to reconstitute synthetic nanoscale binary/ternary lipoprotein complexes composed of apolipoproteins/peptides and lipids that mimic native high-density lipoproteins (HDLs) with the goal to transport drugs. It traces the historical development of our understanding of these nanostructures and how the cholesterol accepting property of HDL has been reconfigured to develop them as drug-loading platforms. The review provides the structural perspective of these platforms with different types of apolipoproteins and an overview of their synthesis. It also examines the cargo that have been loaded into the core for therapeutic and imaging purposes. Finally, it lays out the merits and challenges associated with apolipoprotein-based nanostructures with a future perspective calling for a need to develop “zip-code”-based delivery for therapeutic and diagnostic applications.

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Section: Antioxidant Anti-inflammatory and Anti-atherogenic Agentsmentioning

confidence: 99%

Reconfiguring Nature’s Cholesterol Accepting Lipoproteins as Nanoparticle Platforms for Transport and Delivery of Therapeutic and Imaging Agents

2020

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“…The total antioxidant capacity of barley and oat grain was subject to the effect of both environmental factors (weather conditions, fertilization, etc.) and the genotype (Polonskiy et al, 2016а;Mareček et al, 2017). To assess the effect of the genotype, year and place of growing on the content of protein, lipids, tocol and lutein in whole-grain flour, samples of einkorn wheat and samples of common wheat were cultivated for two years in four different places in Italy.…”

Section: Plant Sciencementioning

confidence: 99%

Biological role and health benefits of antioxidant compounds in cereals

Polonskiy

Loskutov

Сумина

2020

BioComm

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Substances inhibiting or preventing oxidative damage in the target molecule are called antioxidants. It has been shown that antioxidants are substances that contribute to the prevention of a number of serious human diseases, and antioxidant activity is one of the important parameters for the quality of food products and ingredients. Phenolic compounds are of greatest importance for this review. It is now established that whole grain cereals contain a large number of bound polyphenols. It is known that cereals have high nutritional value, contain unsaturated fatty acids, basic mineral elements, proteins and β-glucans, and are also characterized by the presence of various chemical substances with antioxidant properties. In recent years, work has begun in some Western countries to study the content of antioxidants in various grains. In Russia, only a small amount of work has been devoted to the study of these important chemical compounds in grain crops. It should be noted that, although these species are considered to be one of the main components of human nutrition, research in the field of determining their antioxidant activity has not been sufficiently carried out. In order to attract the attention of plant growers, plant breeders, plant physiologists, geneticists and biotechnologists, we offer a review of current literature.

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“…Apart from that, the binding of plant polyphenols has been associated with cardiovascular benefits in relation to LDL oxidation. Various plant phenols such as quercetin, resveratrol, PCA and PHBA have showed their ability to relatively bind with LDL [39]. It has been reported that the binding of LDL by plant phenols showed better resistance to oxidation than LDL alone [40].…”

Section: Of 18mentioning

confidence: 99%

The Effects and Potential Mechanism of Oil Palm Phenolics in Cardiovascular Health: A Review on Current Evidence

2020

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Cardiovascular disease (CVD) is globally known as the number one cause of death with hyperlipidemia as a strong risk factor for CVD. The initiation of drug treatment will be recommended if lifestyle modification fails. However, medicines currently used for improving cholesterol and low-density lipoprotein cholesterols (LDL-C) levels have been associated with various side effects. Thus, alternative treatment with fewer or no side effects needs to be explored. A potential agent, oil palm phenolics (OPP) recovered from the aqueous waste of oil palm milling process contains numerous water-soluble phenolic compounds. It has been postulated that OPP has shown cardioprotective effects via several mechanisms such as cholesterol biosynthesis pathway, antioxidant and anti-inflammatory properties. This review aims to summarize the current evidence explicating the actions of OPP in cardiovascular health and the mechanisms that maybe involved for the cardioprotective effects.

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Binding of Plant Polyphenols to Serum Albumin and LDL: Healthy Implications for Heart Disease

Cited by 33 publications

References 54 publications

Reconfiguring Nature’s Cholesterol Accepting Lipoproteins as Nanoparticle Platforms for Transport and Delivery of Therapeutic and Imaging Agents

Reconfiguring Nature’s Cholesterol Accepting Lipoproteins as Nanoparticle Platforms for Transport and Delivery of Therapeutic and Imaging Agents

Biological role and health benefits of antioxidant compounds in cereals

The Effects and Potential Mechanism of Oil Palm Phenolics in Cardiovascular Health: A Review on Current Evidence

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