Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells

Sun, Yuqi; Dai, Chunmei; Zheng, Yan; Shi, Shudan; Hu, Haiyang; Chen, Dawei

doi:10.1016/j.lfs.2017.07.032

Cited by 18 publications

(15 citation statements)

References 22 publications

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“…Glycyrrhetinic acid (GA), a pentacyclic triterpene derivative, is a major active agent extracted from liquorice (the root of Glycyrrhiza uralensis Fisch.) [13]. GA possessed extensive therapeutic effects, such as anti-cancer, anti-inflammatory and anti-viral effects [14].…”

Section: Introductionmentioning

confidence: 99%

Hepatic targeting of glycyrrhetinic acid via nanomicelles based on stearic acid-modified fenugreek gum

Zhou

Sheng

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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This study aimed to increase the solubility of glycyrrhetinic acid (GA) in water and enhance its liver-targeting ability using self-assembling nanomicelles (NMs) based on stearic acid-modified fenugreek gum . The GA/FG-C 18 NMs were prepared by an ultrasonication dispersion method. The nanomicelles were spherical particles with a particle size of 198.61 ± 1.58 nm and a zeta potential of À30.12 ± 0.28 mV. The drug loading and encapsulation efficiency were 13.34 ± 0.24% and 80.07 ± 1.44%, respectively. The results of differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) indicated that GA was successfully encapsulated into the nanomicelles in a molecularly dispersed state. An in vitro release test showed that GA/FG-C 18 NMs possessed a slow drug release profile in PBS (pH 7.4) over 200 h. The cytotoxicity assay indicated that GA/FG-C 18 NMs showed much higher inhibitory efficacy in HepG2 cells than in MCF-7 cells. Tissue section studies indicated that the accumulation of DiR-loaded FG-C 18 nanomicelles in the liver of mice was higher than that of the DiR solution, and the fluorescence intensity decreased over time. GA/FG-C 18 NMs showed a larger area under the curve (AUC) and mean residence time (MRT) compared with free GA after intravenous administration in mice. The in vivo studies showed that GA mainly accumulated in the liver after encapsulation by FG-C 18 NMs, and the drug concentration was higher than that of free GA. These results suggested that FG-C 18 NMs could serve as a potential drug delivery system for targeting GA to liver tissue.

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Section: Introductionmentioning

confidence: 99%

Hepatic targeting of glycyrrhetinic acid via nanomicelles based on stearic acid-modified fenugreek gum

Zhou

Sheng

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…In doxorubicin-loaded CTS/PEG-GA nanoparticles (Tian et al, 2010), GA can target GA receptors on liver cancer cells. Also, GA receptors have been shown to be useful as liver-cancer targets in GA NFs (Sun et al, 2017). Similarly, in quercetin/Fe (III) (Bertleff-Zieschang et al, 2017) delivery, quercetin (as a phenolic compound) can form a complex organic-inorganic network with iron and gallic acid, and STE contributes to regulation of iron ions to form an "ideal" size of magnetic nanoparticles.…”

Section: The Endoperoxide Linkages (R-o-o-rmentioning

confidence: 99%

Smart Responsive Nanoformulation for Targeted Delivery of Active Compounds From Traditional Chinese Medicine

et al. 2020

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Traditional Chinese medicine (TCM) has been used to treat disorders in China for ~1,000 years. Growing evidence has shown that the active ingredients from TCM have antibacterial, antiproliferative, antioxidant, and apoptosis-inducing features. However, poor solubility and low bioavailability limit clinical application of active compounds from TCM. “Nanoformulations” (NFs) are novel and advanced drug-delivery systems. They show promise for improving the solubility and bioavailability of drugs. In particular, “smart responsive NFs” can respond to the special external and internal stimuli in targeted sites to release loaded drugs, which enables them to control the release of drug within target tissues. Recent studies have demonstrated that smart responsive NFs can achieve targeted release of active compounds from TCM at disease sites to increase their concentrations in diseased tissues and reduce the number of adverse effects. Here, we review “internal stimulus–responsive NFs” (based on pH and redox status) and “external stimulus–responsive NFs” (based on light and magnetic fields) and focus on their application for active compounds from TCM against tumors and infectious diseases, to further boost the development of TCM in modern medicine.

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“…For example, lower pH (Chen et al., 2014; Lv et al., 2016; Hong et al., 2017) and higher glutathione (GSH) levels (Cheng et al., 2011; Raza et al., 2018) have been reported in TME. Studies on tumor surface proteins have reported the presence of multiple specific receptors, such as CD44 receptors (Chen et al., 2016, 2017a; Dong et al., 2018), folate receptors (Chen et al., 2017b), glycyrrhetinic acid receptors (Tian et al., 2012; Sun et al., 2017; Wang et al., 2018b; Yan et al., 2018), and transferrin receptors (Zhao et al., 2018). Based on the specificities of tumor cells, formulation workers have designed a range of targeted agents for the targeted delivery of anti-cancer drugs to tumor sites (Wang et al., 2018a, 2018c).…”

Section: Introductionmentioning

confidence: 99%

Development of dual-targeted nano-dandelion based on an oligomeric hyaluronic acid polymer targeting tumor-associated macrophages for combination therapy of non-small cell lung cancer

et al. 2019

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Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells

Cited by 18 publications

References 22 publications

Hepatic targeting of glycyrrhetinic acid via nanomicelles based on stearic acid-modified fenugreek gum

Hepatic targeting of glycyrrhetinic acid via nanomicelles based on stearic acid-modified fenugreek gum

Smart Responsive Nanoformulation for Targeted Delivery of Active Compounds From Traditional Chinese Medicine

Development of dual-targeted nano-dandelion based on an oligomeric hyaluronic acid polymer targeting tumor-associated macrophages for combination therapy of non-small cell lung cancer

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