Development of dual-targeted nano-dandelion based on an oligomeric hyaluronic acid polymer targeting tumor-associated macrophages for combination therapy of non-small cell lung cancer

Wang, Bingjie; Zhang, Wei; Zhou, Xiudi; Liu, Mengna; Hou, Xiaoya; Cheng, Ziting; Chen, Daquan

doi:10.1080/10717544.2019.1693707

Cited by 54 publications

(30 citation statements)

References 64 publications

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“…Nanodandelions can easily enter tumour tissue through the vascular barrier due to their small size. Effective antitumour activity and reduced side effects were confirmed in antitumour experiments in A549 tumour-bearing mice [ 150 ]. Sustained-release characteristics of NPs may aid the effectiveness of chemotherapy by maintaining drug concentrations at the tumour site for longer durations.…”

Section: Cancer Therapymentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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Section: Cancer Therapymentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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“…Recently, the HA-based nanoparticles were employed to deliver herbal extracts so as to promote cancer immunotherapy. Wang et al [ 274 ] developed quercetin-dithiodipropionic acid-oligomeric hyaluronic acid-mannose-ferulic acid (Que-S-S-oHA- Man-FA, QHMF) to form dandelion-like nanomicelles for delivering both curcumin and baicalin into tumor tissues. They demonstrated that these drug-loaded nanomicelles could easily penetrate through vascular barriers and enter tumor tissues.…”

Section: Hyaluronic Acid-based Nanomedicinesmentioning

confidence: 99%

Polysaccharide-based nanomedicines for cancer immunotherapy: A review

Zeng

Xiang

Sheng

et al. 2021

Bioactive Materials

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Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low targeting (or off-target) efficiency. To overcome these shortcomings, a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects. Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties, as they could interact with immune system to stimulate an enhanced immune response. Their structures offer versatility in synthesizing multifunctional nanocomposites, which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues. This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics.

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“…A similar micellar delivery system, encapsulating CUR and baicalin, was found to induce macrophage remodeling towards a tumor-suppressive phenotype (B. Wang et al, 2019), while dendrosomal nano-CUR induced macrophage switching from the M2 phenotype to the M1 phenotype (Shiri et al, 2015). A dual-pH-sensitive polymeric nanodrug carrying an anti-PD-1 antibody on the shell and CUR in the core was developed by Xiao et al (Z. Xiao et al, 2020).…”

Section: Non-flavonoidsmentioning

confidence: 99%