Bifidobacteria and Their Role as Members of the Human Gut Microbiota

O’Callaghan, Amy; Sinderen, Douwe van

doi:10.3389/fmicb.2016.00925

Cited by 643 publications

(487 citation statements)

References 167 publications

(263 reference statements)

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“…; Cronin et al . ; O'callaghan and van Sinderen ). Bifidobacteriaceae and Coriobacteriaceae have been also associated with human colonic health and IBD remission (Morgan et al .…”

Section: Discussionmentioning

confidence: 99%

Faecal freezing preservation period influences colonization ability for faecal microbiota transplantation

et al. 2019

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Aims There has been growing interest in faecal microbiota transplantation (FMT) as treatment. Although, frozen donor faeces preserved at −20°C has been widely used for practical advantages, freezing at −20°C can affect bacterial viability. Adequacy evaluation of fresh and frozen faeces as the transplant is necessary for the methodological improvement of FMT. Methods and Results The viable bacterial compositions of faecal specimens under fresh and freezing conditions were compared by a microbiome analysis using propidium monoazide (PMA microbiome). In addition, recovery abilities from bacterial reduction by antibiotics were compared between fresh and frozen FMT using a murine model. PMA microbiome results suggested that freezing and freeze‐thawing did not significantly affect in vitro faecal bacterial viability. However, the recovery effect from antimicrobial cleansing in frozen FMT was reduced in a freezing time‐dependent manner, especially prominent in Actinobacteria and Bacteroidetes phyla. Conclusions Short‐term freezing preservation of faeces exhibited maintenance of enteric colonization ability in frozen FMT in comparison to 1 month −20°C‐preservation. Significance and Impact of the Study Long‐term −20°C‐preservation of transplanted faeces can result in instability of the clinical outcome in FMT therapy. The standardization of practical procedures of FMT therapy according to disease types is desirable.

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“…; Cronin et al . ; O'callaghan and van Sinderen ). Bifidobacteriaceae and Coriobacteriaceae have been also associated with human colonic health and IBD remission (Morgan et al .…”

Section: Discussionmentioning

confidence: 99%

Faecal freezing preservation period influences colonization ability for faecal microbiota transplantation

et al. 2019

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“…More research will be needed to understand the relation between production and various microbial groups in the cecum. Bifidobacterium species are frequently associated with health‐promoting effects in the human and animal intestinal tracts (Arboleya, Watkins, Stanton, & Ross, ; O'Callaghan & van Sinderen, ; Combes et al., ). Notably, the 300 g/kg NDF group (Diet C) led to significantly increased Bifidobacterium .…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary fiber levels on bacterial composition with age in the cecum of meat rabbits

Zhou

et al. 2018

MicrobiologyOpen

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This study investigated the influence of dietary fiber levels on the growth performance, digestion, metabolism, and cecal microbial community of rabbits with different diets at different age. The different levels of dietary natural detergent fiber (NDF) were formulated accordingly: 400(A), 350(B), 300(C), 250(D) g/kg original matter basis, respectively; the different ages were 52, 62, and 72 days. With NDF increasing, the average daily feed intake (ADFI) and feed conversion rate (FCR) were increased, whereas average daily gain (ADG) and mortality were decreased (p < 0.05). The stomach relative weight, stomach content relative weight, cecal relative weight, and cecal content weight increased with increasing NDF (p < 0.05). The NH -N concentration of cecum dropped when the dietary NDF increased (p < 0.05). The diversity of the total microbiota increased significantly in Diets B, C (p = 0.011), and reached the lowest in 52 days for all diet groups. The richness index was decreased significantly in Diet A, D (p < 0.05) and in 62 days (p < 0.001), respectively. The phylum Firmicutes was higher (p < 0.01) in rabbits fed Diets B, C than Diets A, D and Bacteroidetes was highest in Diets C, D, and Proteobacteria was the highest in Diet A (p < 0.001). Among the classified genera, there were 14 that had levels of abundance of more than 1% and were commonly shared by all samples. Ruminococcus spp. that produced volatile fatty acid (VFA) abundance was highest from Diets B, C at 52 and 62 days. It is interesting to note that Bifidobacterium from Diet C was the most abundant genus during the entire experimental period (p < 0.01). The data from Venn diagrams, principal component analysis (PCA), and heat map plots of the bacterial communities showed that there were more groups of shared microbiota with aging. The above results indicate the cecal microbiota controlled by the 350 g/kg NDF diet can prevent gastrointestinal distress and exhibit good production performance.

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“…Please notice that most non-dairy probiotic drinks do not contain Bifidobacteria neither in their fermenting formulas nor as gastro-resistant probiotics. It is known that Bifidobacteria are among the first microbes to colonize the human gastrointestinal tract and there is ample consensus that they exert positive health benefits on their host with particular reference to the immune system (O'Callaghan and van Sinderen, 2016).…”

Section: Discussionmentioning

confidence: 99%

Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System

Pacini¹,

Ruggiero²

2017

American Journal of Immunology

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It is estimated that the first processed food products consumed by humans pertained to the category of fermented foods and beverages such as beer, wine, sauerkraut, fermented sausage as well as fermented milk derivatives such as yogurt and kefir. Thus, fermented foods are endowed with undisputed healthy properties due to the presence of probiotic microbes that not only help supporting the healthy human microbiota, but also produce bioactive or bio-available metabolites that contribute to the host's wellbeing. It is widely acknowledged that modulation of the immune system is one of the beneficial effects associated with consuming fermented food products rich in live probiotics and this effect is being exploited in the field of natural immunotherapy. Here we describe the genesis and development of a novel, non-dairy product that may represent a novelty in the field of probiotic drinks since it combines the healthy properties of dairy-based products with the properties of non-dairy probiotic drinks. The major improvements over the existing non-dairy probiotic drinks consist in the number and diversity of probiotic strains endowed with healthpromoting properties and in the presence of a glycosaminoglycan, chondroitin sulfate, that is, at the same time, a newly identified prebiotic and a supplement known to modulate the immune system.

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Bifidobacteria and Their Role as Members of the Human Gut Microbiota

Cited by 643 publications

References 167 publications

Faecal freezing preservation period influences colonization ability for faecal microbiota transplantation

Faecal freezing preservation period influences colonization ability for faecal microbiota transplantation

Effect of dietary fiber levels on bacterial composition with age in the cecum of meat rabbits

Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System

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