Bicyclische α‐Hydroximinoamidine

Abstract

B-ren.-Aminopropionamidoxime reagieren mit Quecksilber(II)-EDTA in CyClodehydrieNngS&tiOIIen zu anelliean a-Hydroximinoamidinen. bargruppe als Nuclmphil. Die Rodukte an der C=N-Doppelbindung der Oxim-Partialstruktur isomerisiert, so Gemische der stermisomeren resultieren. Bicyclic a-Hydroximinomidines anellated a-hydroximinoamidines. In the intramolecular cyclization the sp3hybridized N-atom represents the nucleophilic site. The products consist of stereoisomers showing different configuration concerning the C=N-double bond of the oxime moiety. fungien d a sp3-hybridisiea S t i c~t o f f~o m der Amidoxim-Nach-Reaction of Ptehw aminopwion~idoximes edta leads to He@)-DTA : < (Ph+)aO cyN$ ' ) In den Formeln 3 und 5-11 entsprechen die Reste fiir a und b R = H und fur c-e R = Ph; f i r n s. Namen im Experim. Teil.

Oximes of Seven-Membered Heterocyclic Compounds Containing One Heteroatom

“…Hydrogenation of 4-nitro-2,3-dihydrobenzo[b]thiepine 1,1-dioxide (22) in the presence of 10% Pd/C in dioxane affords oxime 23 in 68% yield [36]. …”