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Data on the production and the reactions of quinoline aldoximes and ketoximes and their derivatives are reviewed. The synthesis of new heterocycles based on quinoline oximes is examined separately. The main results from investigation of the biological activity of quinoline oximes are presented.Quinoline oximes are widely used as intermediates in organic synthesis. In the present paper the principal methods for the production of quinoline oximes and their reactions are reviewed. Methods for the synthesis of new heterocyclic systems from derivatives of these oximes are considered under a separated heading. The principal methods for investigation of the structure of quinoline oximes with regard to isomerism are also briefly discussed. In the last section the results from investigation of the biological activity of the derivatives of quinoline oximes are described.

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Organo-silicon compoundsOrgano-silicon compounds S 0060 Synthesis and Cytotoxicity of 3-(Hetarylthio)-1-propynyl(trimethyl)silanes. -A novel two-step method for the synthesis of title silanes via phase-transfer catalyzed S-alkylation of corresponding heterocyclic thiols (I) with propargyl bromide followed by a silylation reaction is described. The biological activity of the compounds obtained is studied for two tumor cell lines (HT-1080 and MG-22A). Indole derivative (VII) displays the greatest cytotoxicity. -(ABELE, R.; ABELE, E.; RUBINA, K.; DZENITIS, O.; ARSENYAN, P.; SHESTAKOVA, I.; NESTEROVA, A.; DOMRACHEVA, I.; POPELIS, J.; GRINBERGA, S.; et al.; Chem. Heterocycl.