Data on the production and the reactions of quinoline aldoximes and ketoximes and their derivatives are reviewed. The synthesis of new heterocycles based on quinoline oximes is examined separately. The main results from investigation of the biological activity of quinoline oximes are presented.Quinoline oximes are widely used as intermediates in organic synthesis. In the present paper the principal methods for the production of quinoline oximes and their reactions are reviewed. Methods for the synthesis of new heterocyclic systems from derivatives of these oximes are considered under a separated heading. The principal methods for investigation of the structure of quinoline oximes with regard to isomerism are also briefly discussed. In the last section the results from investigation of the biological activity of the derivatives of quinoline oximes are described.
Organo-silicon compoundsOrgano-silicon compounds S 0060 Synthesis and Cytotoxicity of 3-(Hetarylthio)-1-propynyl(trimethyl)silanes. -A novel two-step method for the synthesis of title silanes via phase-transfer catalyzed S-alkylation of corresponding heterocyclic thiols (I) with propargyl bromide followed by a silylation reaction is described. The biological activity of the compounds obtained is studied for two tumor cell lines (HT-1080 and MG-22A). Indole derivative (VII) displays the greatest cytotoxicity. -(ABELE, R.; ABELE, E.; RUBINA, K.; DZENITIS, O.; ARSENYAN, P.; SHESTAKOVA, I.; NESTEROVA, A.; DOMRACHEVA, I.; POPELIS, J.; GRINBERGA, S.; et al.; Chem. Heterocycl.
Data on the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives are reviewed. The synthesis of new heterocycles based on the oximes of six-membered heterocyclic compounds with two and three heteroatoms is considered separately. The principal results of research into the biological activity of these oximes and their ethers are also presented.The oximes of six-membered heterocyclic compounds with two and three heteroatoms are widely used as intermediates in fine organic synthesis. Their production methods and structural features were examined in the review [1]. In this article we discuss the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives. Methods for the synthesis of new heterocyclic systems from the derivatives of these oximes are considered in a separate section. In the last section some results from investigation of the biological activity of the ethers of these oximes are considered.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.