Beyond native deoxyribonucleic acid, templating fluorescent nanomaterials for bioanalytical applications: A review

The Fluorescent Palette of DNA-Templated Silver Nanoclusters for Biological Applications

“…In recent years, nucleic acids (especially DNA) have stood out as excellent building blocks for nano-construction due to the programmability and specificity of the Watson-Crick base pairing (Chen et al, 2015;Li et al, 2018d). For DNA-templated nanomaterials, DNA molecules are first used as templates during the synthesis of nanomaterials, after which it can also be utilized as recognition units to avoid subsequent functional modifications (Qing et al, 2020). DNA-functionalized nanomaterials offer the ability to directly address the desired targets while enhancing the utility of these components during sensing and imaging (Pandya et al, 2016;Tian et al, 2020).…”

Aptamer-functionalized nanomaterials for biological applications

“…The properties of these functionalized nanomaterials may play a key role in biomedical applications; for example, the efficient self-delivery to cancer cells is the first condition for exploring the intracellular environment. 62,63 3.1 Large specific surface area and abundant, easily accessed metal sites With decrease in particle size, the specific surface area of nanomaterials increases greatly, and the number of surface atoms has also increased substantially as a proportion of the total number of particles. An increase in the total number of surface atoms will lead to an increase in the coordination unsaturated properties of surface atoms, which will result in a large number of suspended bonds and unsaturated bonds.…”

Nucleoside-regulated catalytic activity of copper nanoclusters and their application for mercury ion detection

“…Therefore, various metal nanoparticles are synthesized using DNA molecules as templates. 16,17 Since Dickson's group first reported DNAtemplated silver nanoclusters in 2004, a variety of silver nanoclusters with different spectra have been discovered and applied. 18,19 Subsequently, double-stranded DNA (dsDNA) was found to mediate the synthesis of copper nanoclusters.…”