Best herbs for managing diabetes: a review of clinical studies

Ghorbani, Ahmad

doi:10.1590/s1984-82502013000300003

Cited by 99 publications

(69 citation statements)

References 42 publications

(40 reference statements)

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“…These include Allium sativa, Gymnema sylvestre, Ocimum sanctum, Pterocarpus marsupium, Trigonella foenum graecum and Tinospora cordifolia. Moreover, most of these plants were clinically tested; the results were recommendation that physicians can depend on herbs in alleviating diabetes and its complications (Ghorbani, 2013;Pandey et al, 2011). Therefore, these herbal plants could be an alternative therapy for diabetes and its complications (Khan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Many of the health benefits associated withPolysaccharides from the plants were isolated using hot extraction method and then hydrolyzed. The polysaccharide hydrolysates were identified using high performance liquid chromatographic technique. Maximum yield of total polysaccharides identified were obtained from A 7 (12.04%), A 1 (8.51%), A 8 (8.03%), A 2 (5.32%) and A 6 (2.18%) respectively. The isolated polysaccharides were tested for antihyperglycemic activity in alloxan-induced diabetic rats and alpha glucosidase inhibitory activity. Chromatographic investigation of the polysaccharides recorded the presence of 18 saccharides, glucuronic acid, stachyose, galacturonic acid, sucrose, glucose, xylose, galactose, rhamnose, mannose, arabinose, fructose polyol, mannitol and sorbitol in the eight Aloe species, but their quantitative composition differed among the species. Glucuronic acid, stachyose and galacturonic acid were the major detected saccharides. The results of the biological activities revealed significant antihyperglycemic activities with variable degrees. After four weeks of daily administration, polysaccharides isolated from A. vera (A 1 ) and A. arborescens (A 2 ) were the most active with 40 and 44% reduction in blood glucose level, respectively. All the tested polysaccharides showed significant alpha glucosidase inhibitory activity with IC50 (µg/ml) 11.70, 14.60 and 15.80 for A 7 , A 6 and A 1 respectively. In conclusion, the tested polysaccharides contribute to the antidiabetic action of these Aloe species.

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Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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show abstract

“…The beneficial effects of estradiol on glucose homeostasis and body weight were mimicked by T. foenum-graecum. Hypoglycemic effect of T. foenumgraecum has been demonstrated previously in several experimental and clinical studies (27). This effect may be achieved by inhibition of intestinal glucose absorption, enhancing insulin actions on tissues, and activation of hepatic enzymes (28,29).…”

Section: Discussionmentioning

confidence: 69%

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Abedinzade¹,

Nasri²,

Omodi³

et al. 2015

Iran Red Crescent Med J

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Background: Several experimental and clinical studies support beneficial effects of Trigonella foenum-graecum (fenugreek) in the management of metabolic diseases and inflammatory disorders. Objectives: The purpose of this study was to examine the effect of T. foenum-graecum seed extract in reducing the metabolic and inflammatory alternations associated with menopause. Materials and Methods: In this experimental study, 49 rats were divided into seven groups: (I) sham-control, (II) ovariectomized-control, (III and IV) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum seed ethanolic extract, (V and VI) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum hexanic extract, (VII) ovariectomized-positive control treated with 10 µg/kg of estradiol. The extracts were injected intraperitoneally one day after ovariectomy and the treatments were lasted for 42 days. Results: Fasting blood glucose and body weight gain increased significantly in the ovariectomized-control group compared with that in the sham animals (P < 0.05). Administration of estradiol and T. foenum-graecum (50 and 150 mg/dL of hexanic extract and 150 mg/kg of ethanolic extract) significantly diminished the increase in glucose and body weight (P < 0.05). The serum level of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the ovariectomized control group was significantly higher than those in the sham animals (P < 0.05). Both hexanic and ethanolic extracts as well as estradiol were able to decrease level of these cytokines in the serum of ovariectomized rats (P < 0.05). Conclusions:The results of the present study show that administration of T. foenum-graecum corrects metabolic and inflammatory alterations associated with ovariectomy and has a potential for the management of menopause.

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“…[2] Pathophysiology of diabetic vascular disease referred mainly to an abnormality in endothelial and smooth muscle cells related directly with the low level of some biologically active substances such as nitric oxide under the effect of hyperglycemia. [3] Current drug treatment of diabetes besides insulin is oral hypoglycemic drugs including insulin sensitizers (biguanides, thiazolidinediones), insulin secretagogues (sulfonylureas, meglitinides), α-glucosidase inhibitors, incretin agonists, and dipeptidyl peptidase-4.…”

Section: Introductionmentioning

confidence: 99%

“…[4] Therefore, the search for new antidiabetic agent alternatives with more effectiveness and less side effects has been continued. [2,[9][10][11][12] It was reported that their effects were due to the existence of many phytochemicals including alkaloids, flavonoids, glycosides, glycolipids, polysaccharides, peptidoglycans, carbohydrates, amino acids, and saponins. [9] The present study was planned to overlook the effect of a medicinal plant rosemary (R. officinalis) on fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and Vitamin B12 levels in healthy human compared to Type 2 diabetic patients incorporated to glucomid and/or metformin treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of rosemary on fasting blood glucose, hemoglobin A1c and Vitamin B12 in healthy person and Type 2 diabetic patients taking glucomid or/and metformin

Shawabkeh¹,

Jamal²

2017

Natl J Physiol Pharm Pharmacol

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Background: Diabetes mellitus (DM) is risky threats to human health nowadays, and various trials of treatments were announced including chemical and drugs extracted from medicinal plants. Rosemary plants were shown to have antidiabetic and antilipidemic effects. Aims and Objective: Evaluate and investigate the effect of Rosemary administration on hemoglobin A1c (HbA1C) and Vitamin B12 in healthy and diabetic patient who intake glucomid or metformin. Materials and Methods: Forty individuals with Type 2 diabetes of both genders and 10 healthy persons of age 40 years or older were recruited for participating in this study. Diabetic patients were divided into two groups: The first one was taking only glucomid, and the other group was taking both glucomid and metformin together. Rosemary was supplemented as 500 mg powder-encapsulated. All participants were asked to intake 3 g/day (2 capsules at breakfast, lunch, and dinner)and be conducted for 8 weeks. Results: Our data and results showed that rosemary has potentially significant effects on fasting blood glucose (FBG), HbA1c and Vitamin B12 in both healthy and patient's participants. In healthy persons, level of Vitamin B12 was improved 29%, with some effect on HbA1c and FBG (5%, 14%, respectively). In diabetic patients, who were uptaking glucomid only, a significant reduction about 16-18% in both FBG and HbA1c, with a prominent increase in Vitamin B12 level (25%). On the other hand, patients who were receiving both glucomid and metformin responded more effectively to rosemary in FBG and HbA1c (23%) with less increase in Vitamin B12 (10%). In comparison between the levels of Vitamin B12 before rosemary consumption, data indicated that Vitamin B12 level in diabetic patients was 40% less than healthy persons notifying that diabetic patient may suffer from Vitamin B12 deficiency. Conclusion: The present results declare that rosemary can exert significant effects on improving levels of FBG, HbA1c, and Vitamin B12 in both healthy persons and diabetic patients involved in antidiabetic medication.

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Best herbs for managing diabetes: a review of clinical studies

Cited by 99 publications

References 42 publications

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Effect of rosemary on fasting blood glucose, hemoglobin A1c and Vitamin B12 in healthy person and Type 2 diabetic patients taking glucomid or/and metformin

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