2015
DOI: 10.5812/ircmj.17(5)2015.26685
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Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Abstract: Background: Several experimental and clinical studies support beneficial effects of Trigonella foenum-graecum (fenugreek) in the management of metabolic diseases and inflammatory disorders. Objectives: The purpose of this study was to examine the effect of T. foenum-graecum seed extract in reducing the metabolic and inflammatory alternations associated with menopause. Materials and Methods: In this experimental study, 49 rats were divided into seven groups: (I) sham-control, (II) ovariectomized-control, (III a… Show more

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Cited by 8 publications
(9 citation statements)
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“…They were identified as rich source of steroidal saponins (protodioscin, diosgenin, yamogenin), polyphenols (choline, luteolin, orientin, quercetin), alkaloids (pyridine, trigonellin), a non-proteinogenic amino acid ‘4-hydroxyisoleucine’ and galactomannans [ 9 , 11 , 12 , 3 ]. Fenugreek seeds were clinically evaluated for pre- and post-menopausal discomforts [ [13] , [14] , [15] , [16] ]. Earlier studies reported the ability of a hydro-ethanolic extract of fenugreek seeds in improving the sexual function of healthy men and women [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…They were identified as rich source of steroidal saponins (protodioscin, diosgenin, yamogenin), polyphenols (choline, luteolin, orientin, quercetin), alkaloids (pyridine, trigonellin), a non-proteinogenic amino acid ‘4-hydroxyisoleucine’ and galactomannans [ 9 , 11 , 12 , 3 ]. Fenugreek seeds were clinically evaluated for pre- and post-menopausal discomforts [ [13] , [14] , [15] , [16] ]. Earlier studies reported the ability of a hydro-ethanolic extract of fenugreek seeds in improving the sexual function of healthy men and women [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…Some studies have shown the useful effects of medicinal plants in improving diseases such as diabetes, menopause and many others [7,12,13].…”
Section: Introductionmentioning
confidence: 99%
“…There is emerging evidence of the importance of estrogen as both an antiinflammatory and neuroprotective agent (Hsieh et al , ). Interestingly, a recent study showed that T. foenum‐graecum seed extract significantly decreased serum pro‐inflammatory cytokines (IL‐1, IL‐6 and TNF‐α) and improved metabolic symptoms (including significantly blunting elevated blood glucose levels) in a similar manner to estrogen administration, in ovariectomized rats, a standard experimental model of menopause in rodents (Abedinzade et al , ). Previous studies have reported that compromised glycemic control is also a mediator of hot flush severity during menopause and that diabetic women with elevated HbA1c demonstrated higher menopausal symptom severity scores (Rouen et al , ).…”
Section: Discussionmentioning
confidence: 99%