Benzimidazole-quinoline-based copper complexes: Exploration for their possible antitumor mechanism

Hu, Jingyu; Chao, Tingting; Yuan, Bangpeng; Guo, Yan; Zhang, Junshuai; Resource, Jin'an Zhao; Zhao, Xuemin; Hou, Hongwei

doi:10.1016/j.poly.2021.115563

Cited by 6 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…60 Therefore, the fluorescent probe DCFH-DA was used to further detect the changes in ROS levels due to the loss of mitochondrial function. 61,62 As shown in Fig. 13, the green fluorescence intensity of the Eca-109 cells in the dosing groups significantly increased, confirming that the complexes could induce intracellular ROS production.…”

Section: Dalton Transactions Papermentioning

confidence: 53%

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

Liu

Cai

et al. 2022

Dalton Trans.

View full text Add to dashboard Cite

show abstract

Section: Dalton Transactions Papermentioning

confidence: 53%

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

Liu

Cai

et al. 2022

Dalton Trans.

View full text Add to dashboard Cite

show abstract

“…These are able to treat a broad range of disorders, particularly epilepsy, diabetes, and pregnancy. Such derivatives exhibit a variety of bioactivities like antiallergic [ 61 ], antihistamine [ 62 ], anti-ulcerative, antiproliferative [ 63 ], antioxidant [ 64 , 65 ], antifungal, antibacterial, antitubercular [ 66 ], antihypertensive [ 67 ], anti-inflammatory, analgesic, antiamoebic [ 68 ], antitumor [ 69 , 70 , 71 ], antimalarial [ 72 ], and anti-kinase activity [ 73 ]. Several BnZ derivatives are also being investigated as cholinesterase inhibitors and anti-parasitic drugs [ 74 , 75 , 76 , 77 ].…”

Section: Multifaceted Efficacy Of Benzimidazolementioning

confidence: 99%

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

Patel¹,

Avashthi²,

Gacem

et al. 2023

Molecules

View full text Add to dashboard Cite

Heterocyclic compounds are significant lead drug candidates based on their various structure–activity relationships (SAR), and their use in pharmaceutics is constantly developing. Benzimidazole (BnZ) is synthesized by a condensation reaction between benzene and imidazole. The BnZ structure consists of two nitrogen atoms embedded in a five-membered imide ring which is fused with a benzene ring. This review examines the conventional and green synthesis of metallic and non-metallic BnZ and their derivatives, which have several potential SARs, along with a wide range of pharmacological properties, including anti-cancer, anti-inflammatory, anti-microbial, anti-tubercular, and anti-protozoal properties. These compounds have been proven by pharmacological investigations to be efficient against different strains of microbes. Therefore, in this review, the structural variations of BnZ are listed along with various applications, predominantly related to their biological activities.

show abstract

Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016–2023)

Hagar,

Abbas,

Atef

et al. 2024

Mol Divers

View full text Add to dashboard Cite

Benzimidazole scaffolds have potent anticancer activity due to their structure similarity to nucleoside. In addition, benzimidazoles could function as hydrogen donors or acceptors and bind to different drug targets that participate in cancer progression. The literature had many anticancer agents containing benzimidazole cores that gained much interest. Provoked by our endless interest in benzimidazoles as anticancer agents, we summarized the successful trials of the benzimidazole scaffolds in this concern. Moreover, we discuss the substantial opportunities in cancer treatment using benzimidazole-based drugs that may direct medicinal chemists for a compelling future design of more active chemotherapeutic agents with potential clinical applications. The uniqueness of this work lies in the highlighted benzimidazole scaffold hybridization with different molecules and benzimidazole-metal complexes, detailed mechanisms of action, and the IC50 of the developed compounds determined by different laboratories after 2015.

show abstract

Benzimidazole-quinoline-based copper complexes: Exploration for their possible antitumor mechanism

Cited by 6 publications

References 55 publications

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016–2023)

Contact Info

Product

Resources

About