Beneficial effect of gaseous nitric oxide on the healing of skin wounds

Shekhter, Anatoly B.; Сереженков, В. А.; Rudenko, T. G.; Пекшев, А. В.; Vanin, Anatoly F.

doi:10.1016/j.niox.2005.03.004

Cited by 213 publications

(163 citation statements)

References 15 publications

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Section: Discussionmentioning

confidence: 99%

“…In this context, Shekhter et al discussed the possible influence of plasma-based NO on the phagocytosis of macrophages to improve the regeneration of wounds 38 . Theoretically, acute inflammation has two major components: vascular changes and cellular events 37 .Regarding the former, plasma may play the important role of influencing vascular growth, vascular dilation, and microcirculation normalization, as discussed previously 38 . Regarding the latter, the direct effect of cold plasma on the events of inflammatory cells like macrophages has been unclear, but as we wrote previously, it was reported that cold plasma reduced the migration of fibroblasts 25 and activated their integrin 27 .…”

Section: Discussionmentioning

confidence: 99%

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Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin

Nakajima

Mukai

et al. 2014

Clinical Plasma Medicine

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We investigated cold plasma effects on acute wounds of mice. The mice were classified into experimental and control groups. In the former, wounds were treated using cold plasma once daily for 1 minute, and then covered with hydrocolloid dressing; wounds in the control were left to heal under hydrocolloid dressing. Daily evaluation was conducted for 15 days. General and specific staining was applied to evaluate re-epithelialization, neutrophil, macrophage, myofibroblast and transforming growth factor beta. It was found that cold plasma accelerated wound healing by one day. Plasma may promote the late phase of inflammation, accelerate reepithelialization and increase wound contraction.3

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin

Nakajima

Mukai

et al. 2014

Clinical Plasma Medicine

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“…In NO therapy using the 'indirect' air-plasma source 'Plazon', gas mixture in effluent of the plasma source with NO concentration of 500 ppm improved healing of skin wounds (Shekter, 2005). Our DBD plasma source generates comparatively lower NO flux which is too small for similar skin healing treatments.…”

Section: Comparison Of No and Ozone Fluxes With Other Treatment Methodsmentioning

confidence: 96%

Basics and Biomedical Applications of Dielectric Barrier Discharge (DBD)

Bibinov¹,

Rajasekaran²,

Wandke³

et al. 2011

Biomedical Engineering, Trends in Materials Science

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“…NO was delivered at 160 ppm (~7 µM NO) for 30 min every 4 h to rats with P. aeruginosa airway infection, and the results showed that the NO treatment was able to reduce the infection by more than 2 log [98]. Exposure to NO gas at 500 ppm (~20 µM NO) for 60 s every 24-48 h of external wounds colonised by S. aureus led to faster wound healing by 30%, compared to controls [99]. Wound dressings that release NO levels typically at 500 ppm appeared to be efficient at killing biofilms of nosocomial pathogens Acinetobacter baumannii, MRSA, and P. aeruginosa when assessed in in vitro experiments [100].…”

Section: At Higher Levels No May Be Effective At Killing Biofilmsmentioning

confidence: 99%

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Barraud¹,

Kelso²,

Rice

et al. 2014

CPD

215

196

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Studies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. In contrast to previous attempts using high dose NO aimed at killing pathogens, the use of low, non-toxic NO signals (picomolar to nanomolar range) to disperse biofilms represents an innovative and highly favourable approach to improve infectious disease treatments. Further, several NO-based technologies have been developed that offer a versatile range of solutions to control biofilms, including: (i) NO-generating compounds with short or long half-lives and safe or inert residues, (ii) novel compounds for the targeted delivery of NO to infectious biofilms during systemic treatments, and (iii) novel NO-releasing materials and surface coatings for the prevention and dispersal of biofilms. Overall the use of low levels of NO exploiting its signaling properties to induce dispersal represents an unprecedented and promising strategy for the control of biofilms in clinical and industrial contexts. AbstractStudies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. In contrast to previous attempts using high dose NO aimed at killing pathogens, the use of low, non-toxic NO signals (picomolar to nanomolar range) to disperse biofilms represents an innovative and highly favourable approach to improve infectious disease treatments. Further, several NO-based technologies have been developed that offer a versatile range of solutions to control biofilms, including: (i) NO-generating compounds with short or long half-lives and safe or inert residues, (ii) novel compounds for the targeted delivery of NO to infectious biofilms during systemic treatments, and (iii) novel NO-releasing materials and surface coatings for the prevention and dispersal of biofilms. Overall the use of low levels of NO exploiting its signaling properties to induce dispersal represents an unprecedented and promising strategy for the control of biofilms in clinical and industrial contexts. 3 Increased antimicrobial tolerance in biofilms is the basis for chronic infecti...

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Beneficial effect of gaseous nitric oxide on the healing of skin wounds

Cited by 213 publications

References 15 publications

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Basics and Biomedical Applications of Dielectric Barrier Discharge (DBD)

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

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