Abstract:RESUMO: "Comportamento e ensaios bioenzimáticos com Serjania erecta Radlk., sapindaceae, correlacionados com disfunções cognitivas." O objetivo deste estudo foi pesquisar o extrato bruto de Serjania erecta Radlk., Sapindaceae, e seus bioativos como preventivos ou inibidores de perda de memória em roedores, e outros fatores correlacionados com a síndrome de Alzheimer: atividade antioxidante e anticolinesterásicas, principalmente como planta adaptógena, baixa toxicidade e ação regulatória. A reversão do bloquead… Show more
“…The delayed development and weight loss observed in C. includens may have been related to the phenolic compounds found in the S. erecta extract, including kaempferol 28 , saponins 29 , and apigenins 28 . Phenolic compounds may cause a significant reduction in the survival and growth of insects due to the inactivation of digestive enzymes 30 .…”
Section: Resultsmentioning
confidence: 99%
“…Regarding S. erecta , there are few reports in the literature regarding the inhibitory activity of its extracts. Broggini et al 29 showed the inhibitory effect of crude extracts of this species using thin layer chromatography. In this work, the flavonoid fraction of this extract was shown to be more selective for inhibition of acetylcholinesterase than for that of butyrylcholinesterase, while the saponin fraction showed greater inhibition of butyrylcholinesterase than of acetylcholinesterase 29 .…”
Section: Resultsmentioning
confidence: 99%
“…Broggini et al 29 showed the inhibitory effect of crude extracts of this species using thin layer chromatography. In this work, the flavonoid fraction of this extract was shown to be more selective for inhibition of acetylcholinesterase than for that of butyrylcholinesterase, while the saponin fraction showed greater inhibition of butyrylcholinesterase than of acetylcholinesterase 29 . Thus, the presence of metabolites in the extract of this plant, at a concentration of 31.3 µg mL −1 , is high enough to totally inhibit the activity of carboxyl-esterases.…”
The soybean looper, Chrysodeixis includens, is a primary soybean pest that reduces crop productivity. This work examined control of C. includens populations with methanolic extract of Serjania erecta, a native Cerrado plant, while minimizing risks to pollinators, natural enemies and the environment. Serjania erecta specimens were collected, identified, and subjected to methanol extraction. Bioassays were performed using newly hatched and second-instar caterpillars and different extract concentrations on the diet surface to obtain IC50 values. Two replicates, containing 10 caterpillars, were established in triplicate. The IC50 values were 4.15 and 6.24 mg of extract mL−1 for first-instar and second-instar caterpillars, respectively. These growth inhibition results informed the extract concentrations assessed in subsequent development inhibition assays, in which the pupal weight was higher under the control than under the treatments. Extract treatments increased the duration of the larval, pupal and total development. The potential of different concentrations of S. erecta extract to inhibit the enzymes carboxylesterases was also evaluated. Carboxylesterases activity decreased by 41.96 and 43.43% at 7.8 and 15.6 μg mL−1 extract, respectively. At 31.3 μg mL−1 extract, enzymatic activity was not detected. Overall, S. erecta leaf methanolic extract showed inhibitory potential against carboxylesterases.
“…The delayed development and weight loss observed in C. includens may have been related to the phenolic compounds found in the S. erecta extract, including kaempferol 28 , saponins 29 , and apigenins 28 . Phenolic compounds may cause a significant reduction in the survival and growth of insects due to the inactivation of digestive enzymes 30 .…”
Section: Resultsmentioning
confidence: 99%
“…Regarding S. erecta , there are few reports in the literature regarding the inhibitory activity of its extracts. Broggini et al 29 showed the inhibitory effect of crude extracts of this species using thin layer chromatography. In this work, the flavonoid fraction of this extract was shown to be more selective for inhibition of acetylcholinesterase than for that of butyrylcholinesterase, while the saponin fraction showed greater inhibition of butyrylcholinesterase than of acetylcholinesterase 29 .…”
Section: Resultsmentioning
confidence: 99%
“…Broggini et al 29 showed the inhibitory effect of crude extracts of this species using thin layer chromatography. In this work, the flavonoid fraction of this extract was shown to be more selective for inhibition of acetylcholinesterase than for that of butyrylcholinesterase, while the saponin fraction showed greater inhibition of butyrylcholinesterase than of acetylcholinesterase 29 . Thus, the presence of metabolites in the extract of this plant, at a concentration of 31.3 µg mL −1 , is high enough to totally inhibit the activity of carboxyl-esterases.…”
The soybean looper, Chrysodeixis includens, is a primary soybean pest that reduces crop productivity. This work examined control of C. includens populations with methanolic extract of Serjania erecta, a native Cerrado plant, while minimizing risks to pollinators, natural enemies and the environment. Serjania erecta specimens were collected, identified, and subjected to methanol extraction. Bioassays were performed using newly hatched and second-instar caterpillars and different extract concentrations on the diet surface to obtain IC50 values. Two replicates, containing 10 caterpillars, were established in triplicate. The IC50 values were 4.15 and 6.24 mg of extract mL−1 for first-instar and second-instar caterpillars, respectively. These growth inhibition results informed the extract concentrations assessed in subsequent development inhibition assays, in which the pupal weight was higher under the control than under the treatments. Extract treatments increased the duration of the larval, pupal and total development. The potential of different concentrations of S. erecta extract to inhibit the enzymes carboxylesterases was also evaluated. Carboxylesterases activity decreased by 41.96 and 43.43% at 7.8 and 15.6 μg mL−1 extract, respectively. At 31.3 μg mL−1 extract, enzymatic activity was not detected. Overall, S. erecta leaf methanolic extract showed inhibitory potential against carboxylesterases.
“…The aqueous extract was obtained by the method described by Broggini et al (2010), with adaptations. Leaves were dried in a forced-air circulation incubator with microprocessor and air renewal (Sterilifer -SXCR 40) at 37 ± 2 °C for 48 h and ground through a Wiley mill (TE-680-Tecnal) with a 10-mesh screen.…”
Section: Plant Material Preparation and Chemical Composition Of S Ere...mentioning
confidence: 99%
“…[e.g. Serjania marginata (Périco et al 2015, Moreira et al 2019, Serjania caracasana (Silva et al 2017), and S. erecta (Castelo et al 2009, Broggini et al 2010] in mice. However, no studies have evaluated the toxicity of S. erecta in aquatic organisms.…”
This study was carried out to determine the toxicity and biochemical and morphophysiological changes caused by Serjania erecta leaf aqueous extract in pacu (Piaractus mesopotamicus). For acute toxicity testing (CL 50-4h ), pacu juveniles were exposed during 4 h to Serjania erecta aqueous extract concentrations of 2.5, 12.5, 25, 50, 100, and 150 µg mL -1 , which were added directly to the water in the tanks. In the control group, the animals were kept in water free from aqueous extract. CL 50-4 h was estimated at 57.43 µg mL -1 . After exposure to the aqueous extract, the highest (P<0.05) glucose concentration and the lowest (P<0.05) plasma sodium level were when the fi sh were exposed to the S. erecta concentration of 50 µg mL -1 . Mortality occurred at S. erecta extract levels higher than 50 μg mL -1 , and all fi sh died at concentrations greater than 100 μg mL -1 . In addition, exposure to this extract caused severe histological changes in the gills and liver with higher prevalence of necrosis (30.2%), and fatty degeneration (77.4%) respectively. At the concentrations tested here, S. erecta aqueous extract causes morphofunctional alterations in this fi sh species.
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