Behavior of bioactive glass-ceramic implanted into long bone defects: a scintigraphic study

Abstract

The purpose of the study was to assess the long-term behavior and incorporation of the bioactive oxyhydroxyapatite glass-ceramic used to fill defects of long bones after curettage of bone cysts in 17 patients. The method of evaluation was a three-phase bone scintigraphy combined with radiographic and clinical evaluation. At a mean follow-up of 7 years, the glass-ceramic material had been completely incorporated. Mean uptake ratio was 1.31+/-0.25 after implantation of glass-ceramic in the metaphyseal region and 2.07+/-0.62 after implantation of glass-ceramic in the diaphyseal region (P<0.05). Mean uptake ratio was 1.40+/-0.30 in patients without persistent pain and 2.07+/-0.69 in patients who complained of pain in the area of synthetic filling (P<0.05). The bioactive glass-ceramic can be implanted into the metaphyseal defects of long bones, but this material is not suitable for filling the diaphyseal defects.

Development and Characterization of Ag2O‐Doped ZnLB Glasses and Biological Assessment of Ag2O–ZnLB–Hydroxyapatite Composites

“…In this respect, the addition of wide range of metal or nonmetal oxides to glasses' composition has been shown to improve the biological response to osteoblasts—both in which regards to proliferation and differentiation events—and improve the bone‐bonding ability of developed materials . Accordingly, the clinical application of glass‐ceramic composites has been established and proven to be successful in a wide range of orthopedic and dental interventions …”

“…[14][15][16] Accordingly, the clinical application of glassceramic composites has been established and proven to be successful in a wide range of orthopedic and dental interventions. [17][18][19] Moreover, within the clinical scenario, the adequacy of use of grafting materials may be narrowed by the establishment of biomaterial-related infections. 20 Even though infection is not a common reason for grafting failure, it accounts for an enormous medical cost, increase in morbidity, and a decrease in patient satisfaction.…”

Bone grafting alternatives for cavitary defects in children

“…64 A study of HA/TCP composite mixed with BMA in benign pediatric bone tumor defects also showed comparable healing rates, with a 6% incidence of growth plate arrest (Table 2). 64 A study of HA/TCP composite mixed with BMA in benign pediatric bone tumor defects also showed comparable healing rates, with a 6% incidence of growth plate arrest (Table 2).…”

Use of bioactive glasses as bone substitutes in orthopaedics and traumatology

“…A few studies exist that have examined the use of bioactive glass granules in the treatment of long bone fractures [70]; such as tibia or femoral shaft fractures. These fractures often need repositioning and rigid fi xation.…”