Use of bioactive glasses as bone substitutes in orthopaedics and traumatology

Heikkilä, Jari

doi:10.1533/9780857093318.2.189

Cited by 4 publications

(7 citation statements)

References 81 publications

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“…Because of the exchange of alkali ions, the silica gel-based layer increases in thickness. Moreover, being negatively charged, (4) the newly formed SiO 2 -based layer acts as a template for the gathering of calcium and phosphate ions already present in the body fluids, creating a stratum rich in amorphous calcium phosphate phase on top of the silica gel [ 36 ]. In this phase, (5) the amorphous CaO–P 2 O 5 phase crystallizes as it bonds to hydroxide and carbonate anions from the surroundings, and gradually transforms into a mixed carbonated hydroxyapatite (HCA) [ 35 ].…”

Section: Reaction Of Bioactive Glass With Body Fluidsmentioning

confidence: 99%

“…Finally, bioactive glass plays a key role in the osteogenesis process due to its osteostimulating properties. Indeed, the inorganic dissolution products of bioactive glass granules stimulate the recruitment of osteoprogenitor cells and their proliferation and differentiation into matrix-producing osteoblasts, which increase the local rate of bone remodeling and the healing of bone [ 8 , 36 , 37 ].…”

Section: Reaction Of Bioactive Glass With Body Fluidsmentioning

confidence: 99%

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Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review

2018

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Bone defects caused by trauma or pathological events are major clinical and socioeconomic burdens. Thus, the efforts of regenerative medicine have been focused on the development of non-biodegradable materials resembling bone features. Consequently, the use of bioactive glass as a promising alternative to inert graft materials has been proposed. Bioactive glass is a synthetic silica-based material with excellent mechanical properties able to bond to the host bone tissue. Indeed, when immersed in physiological fluids, bioactive glass reacts, developing an apatite layer on the granule’s surface, playing a key role in the osteogenesis process. Moreover, the contact of bioactive glass with biological fluids results in the increase of osmotic pressure and pH due to the leaching of ions from granules’ surface, thus making the surrounding environment hostile to microbial growth. The bioactive glass antimicrobial activity is effective against a wide selection of aerobic and anaerobic bacteria, either in planktonic or sessile forms. Furthermore, bioglass is able to reduce pathogens’ biofilm production. For the aforementioned reasons, the use of bioactive glass might be a promising solution for the reconstruction of bone defects, as well as for the treatment and eradication of bone infections, characterized by bone necrosis and destruction of the bone structure.

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Section: Reaction Of Bioactive Glass With Body Fluidsmentioning

confidence: 99%

Section: Reaction Of Bioactive Glass With Body Fluidsmentioning

confidence: 99%

Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review

2018

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“…Antibacterial properties are a result of a local pH increase that is caused by the exchange of alkali ions with protons in solution (body fluid) [ 17 ]. The release of salt ions contributes to a higher osmotic pressure, which is also indicated as an antimicrobial factor [ 7 – 9 ], as illustrated in Figure 1 .…”

Section: Clinical Application Of S53p4 Bioactive Glass In the Treamentioning

confidence: 99%

“…Thereafter, a silica gel layer is formed on the glass surface, and amorphous calcium phosphates precipitate on this layer. These amorphous structures then crystalize to natural hydroxyapatite, which starts the activation of osteoblasts for the formation of new bone [ 7 – 9 ]. This mechanism of action is illustrated in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

“…This mechanism of action is illustrated in Figure 1 . Because of the continuous reactions and layer formation, the glass will finally be absorbed [ 7 , 8 ]. The surface reactions not only are beneficial for the formation of new bone but also ensure that bioactive glass contains antibacterial properties and potentially promotes angiogenesis [ 10 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review

Gestel

Geurts

Hulsen

et al. 2015

BioMed Research International

104

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Nowadays, S53P4 bioactive glass is indicated as a bone graft substitute in various clinical applications. This review provides an overview of the current published clinical results on indications such as craniofacial procedures, grafting of benign bone tumour defects, instrumental spondylodesis, and the treatment of osteomyelitis. Given the reported results that are based on examinations, such as clinical examinations by the surgeons, radiographs, CT, and MRI images, S53P4 bioactive glass may be beneficial in the various reported applications. Especially in craniofacial reconstructions like mastoid obliteration and orbital floor reconstructions, in grafting bone tumour defects, and in the treatment of osteomyelitis very promising results are obtained. Randomized clinical trials need to be performed in order to determine whether bioactive glass would be able to replace the current golden standard of autologous bone usage or with the use of antibiotic containing PMMA beads (in the case of osteomyelitis).

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