Bone grafting alternatives for cavitary defects in children

Allison, Daniel C.; McIntyre, James A.; Ferro, A.; Brien, Earl W.; Menendez, Lawrence R.

doi:10.1097/bco.0b013e3182910f94

Cited by 15 publications

(5 citation statements)

References 48 publications

(28 reference statements)

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“…By using different grafts, bone defects would efficiently regenerate under different conditions. The familiar sources of the grafts roughly divided into three categories [ [13] , [14] , [15] ]. 1.…”

Section: Introductionmentioning

confidence: 99%

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Zhao

Zhu

et al. 2021

Bioactive Materials

266

177

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Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic- co -glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Zhao

Zhu

et al. 2021

Bioactive Materials

266

177

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show abstract

“…Bone grafting and biomaterial implantation are widely used for repairing large bone defects and fractures related to traumas, tumors and inflammatory diseases [1,2]. Autografts, allografts and xenografts have a number of associated risks, such as donor deficiency, immunologic rejection and infection [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, implantation of biomaterials has become an important method for bone defects repair [2]. As a biomaterial with good osteoconductivity and osteoinductivity, bioactive glasses (BG) have been widely clinically utilized [5,6].…”

Section: Introductionmentioning

confidence: 99%

The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis

Huang¹,

Gong²,

Huang³

et al. 2022

Biomed. Mater.

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Early angiogenesis is important to facilitate biomaterials’ osteogenic effects and avoid the bone regeneration failure for large-sized bone defects. Bioactive glasses (BG) have been widely utilized as a biomaterial for bone repair. However, the early angiogenesis of BG may be inadequate. In this study, we explored the effects of photobiomodulation (PBM) combined with BG on early angiogenesis to solve this bottleneck problem of insufficient early angiogenesis. In vitro, human umbilical vein endothelial cells (HUVECs) were cultured with BG extracts and treated with PBM using 1 J/cm2. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) and tubule formation assay were utilized to detect HUVECs’ proliferation, vascular growth factor genes expression and tubules formation. In vivo, bone defects at the femoral metaphysis in Sprague-Dawley rats were treated with BG particulates and PBM at 120 J/cm2. Immunohistochemical staining was applied to observe the vascular-like structure formation. In vitro results showed that PBM combined with BG significantly promoted HUVECs’ proliferation, genes expression and mature tubules formation. On days 2, 4 and 7, the VEGF gene expression in BG+PBM group was 2.70-, 2.59- and 3.05-fold higher than control (P<0.05), and higher than PBM and BG groups (P<0.05). On days 4 and 7, the bFGF gene expression in BG+PBM group was 2.42- and 1.82-fold higher than control (P<0.05), and also higher than PBM and BG groups (P<0.05). Tube formation assay showed that mature tubules formed in BG+PBM and PBM groups after 4 hours. The tubules number in BG+PBM group was significantly higher than other groups (P<0.05). In vivo results further confirmed that PBM induced early angiogenesis. More vascular-like structures were observed in BG+PBM and PBM groups 2-week post surgery. In conclusion, with the optimum PBM fluence and BG concentration, PBM combined with BG exerted additive effects on enhancing early angiogenesis.

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“…In recent decades, various techniques such as bone grafting [50] or prosthesis [51][52][53][54][55][56][57] have been used to regenerate bone defects caused by trauma, osteoarthritis, osteoporosis, tumors, etc., but harmful immune responses and insufficient donor tissues are serious disadvantages for the application of these techniques [58][59][60]. In recent years, marine biocomposites, having as sources: corals, fish bone, sponges, shells and snail shells have become a very promising material used in the field of TE [61][62][63][64].…”

Section: Introductionmentioning

confidence: 99%

Microwave Technology Using Low Energy Concentrated Beam for Processing of Solid Waste Materials from Rapana thomasiana Seashells

et al. 2021

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The solid waste of Rapana thomasiana seashells both from domestic activities and natural waste on seashore can be used to obtain viable products for medical applications. However, conventional technologies applied for sintering the materials require massive energy consumption due to the resistance heating. Microwave heating represents an advanced technology for sintering, but the stability of the process, in terms of thermal runaway and microwave plasma arc discharge, jeopardizes the quality of the sintered products. This paper aims to present the results of research focused on viable heating technology and the mechanical properties of the final products. A comparative analysis, in terms of energy efficiency vs. mechanical properties, has been performed for three different heating technologies: direct microwave heating, hybrid microwave heating and resistance heating. The results obtained concluded that the hybrid microwave heating led to final products from Rapana thomasiana solid waste with similar mechanical properties compared with resistance heating. In terms of energy efficiency, the hybrid microwave heating was 20 times better than resistance heating.

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Bone grafting alternatives for cavitary defects in children

Cited by 15 publications

References 48 publications

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis

Microwave Technology Using Low Energy Concentrated Beam for Processing of Solid Waste Materials from Rapana thomasiana Seashells

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