Automated and programmable electromagnetically actuated valves for microfluidic applications

Pradeep, Aarathi; Raj, S. Vineeth; Stanley, John; Nair, Bipin; Babu, T G Satheesh

doi:10.1016/j.sna.2018.09.024

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…Electromagnetic actuators are another group that has been employed in micropump and microfluidic applications exploiting their favorable features for LoC such as rapid response, large force, and low-voltage operation. For instance, Pradeep et al developed an electromagnetically actuated valves to control multiple fluid flow on a programmable microfluidics platform (figure 6(a)) [146]. The device was comprised of polydimethylsiloxane (PDMS) based microfluidic channels and membranes with an electronic board that held solenoids.…”

Section: Lab-on-a-chip (Loc)mentioning

confidence: 99%

MEMS actuators for biomedical applications: a review

Ghazali

Hasan

Rehman

et al. 2020

J. Micromech. Microeng.

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Micro-electromechanical-system (MEMS) based actuators, which transduce certain domains of energy into mechanical movements in the microscopic scale, are increasingly contributing to the areas of biomedical engineering and healthcare applications. They are enabling new functionalities in biomedical devices through their unique miniaturized features. An effective selection of a particular actuator, among a wide range of actuator types available in the MEMS field, needs to be made through the assessment of many factors involved in both the actuator itself and the target application. This paper presents an overview of the state-of-the-art MEMS actuators that have been developed for biomedical applications. The actuation methods, working principle, and imperative features of these actuators are discussed along with their specific applications. An emphasis of this review is placed on temperature-responsive, electromagnetic, piezoelectric, and fluid-driven actuators towards various application areas including lab-on-a-chip, drug delivery systems, cardiac devices and surgical tools. It also highlights the key issues of MEMS actuators in light of biomedical applications.

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Section: Lab-on-a-chip (Loc)mentioning

confidence: 99%

MEMS actuators for biomedical applications: a review

Ghazali

Hasan

Rehman

et al. 2020

J. Micromech. Microeng.

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“…For the detection of single or multiple targets in a real or complex solution, the design of the binding assay usually involves more than one kind of bioreceptors, thus meaning that the designed samples to flow over each bioreceptor spot could be different. The delivering of different kinds of samples in sequential orders can be realized by unique design of microfluidic channels, pneumatic valves [17,37], and/or centrifugal forces [33,34].…”

Section: Advantages Of Microfluidic-integrated Biosensorsmentioning

confidence: 99%

Application of Microfluidics in Biosensors

Wang¹,

Ren²,

Zhang³

2020

Advances in Microfluidic Technologies for Energy and Environmental Applications

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“…Designing a custom microfluidic chip for every application requires a considerable upfront investment, because each new chip design needs to be tested, iterated, and validated for the targeted application. , Programmable microfluidic chips try to overcome this by offering reconfigurable functions, allowing the same chip to be used in multiple different applications. , Currently, most programmable microfluidic devices are based on automating the operation of valves and pumps. − However, tubes, valves, and pumps can quickly become the limiting factor in the miniaturization of microfluidic platforms, , even if the chips themselves can be made very small.…”

Section: Introductionmentioning

confidence: 99%

Programmable Droplet Microfluidics Based on Machine Learning and Acoustic Manipulation

2022

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Typical microfluidic devices are application-specific and have to be carefully designed to implement the necessary functionalities for the targeted application. Programmable microfluidic chips try to overcome this by offering reconfigurable functionalities, allowing the same chip to be used in multiple different applications. In this work, we demonstrate a programmable microfluidic chip for the two-dimensional manipulation of droplets, based on ultrasonic bulk acoustic waves and a closed-loop machine-learning-based control algorithm. The algorithm has no prior knowledge of the acoustic fields but learns to control the droplets on the fly. The manipulation is based on switching the frequency of a single ultrasonic transducer. Using this method, we demonstrate 2D transportation and merging of water droplets in oil and oil droplets in water, and we performed the chemistry that underlies the basis of a colorimetric glucose assay. We show that we can manipulate drops with volumes ranging from ∼200 pL up to ∼30 nL with our setup. We also demonstrate that our method is robust, by changing the system parameters and showing that the machine learning algorithm can still complete the manipulation tasks. In short, our method uses ultrasonics to flexibly manipulate droplets, enabling programmable droplet microfluidic devices.

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Automated and programmable electromagnetically actuated valves for microfluidic applications

Cited by 10 publications

References 32 publications

MEMS actuators for biomedical applications: a review

MEMS actuators for biomedical applications: a review

Application of Microfluidics in Biosensors

Programmable Droplet Microfluidics Based on Machine Learning and Acoustic Manipulation

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