Computational simulation for the fluid flow in a paper based microfluidic system was performed and was experimentally validated in this work. Comsol Multiphysics based simulation was performed and the module used was species transport in porous medium. Two separate simulation for the reagent distribution and the interaction of sample with the immobilized reagent in paper based microfluidics devices were carried out. This was performed by varying the parameters such as adsorption constant, diffusivity and average velocity of fluid in the porous medium for finding the concentration profile. Finer mesh were used for the simulation which gives more accurate results with less computational time. The reagent distribution was experimentally validated by dropping methylorange indicator over Whatman filter paper.
Uniform and rapid mixing between various streams in a microfluidic device is essential for the development of device involving reaction between multiple streams. In this work, microfluidic channels of various geometries were designed and their fluid flow patterns were analyzed to optimize complete mixing of different fluids. The designs were modified by incorporating different types of ridges (square, curved and triangular shaped) in the microfluidic channels. Numerical analysis of the designs was carried out using COMSOL Multiphysics 4.3a. The extent of mixing in each of the design was calculated and the optimized design was fabricated using photolithography followed by soft lithography. The performance of the developed micromixer was studied using colored solutions and it was found to be in good agreement with the simulated results.
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