Australian children and adolescents with type 1 diabetes have low vitamin D levels

Greer, Ristan M.; Rogers, Meredith A; Bowling, Francis; Buntain, Helen; Harris, Mark; Leong, Gary M.; Cotterill, Andrew

doi:10.5694/j.1326-5377.2007.tb01130.x

Cited by 74 publications

(61 citation statements)

References 5 publications

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“…Many studies have reported that vitamin D levels were negatively associated with type 1 diabetes and insulin resistance in children and adults [13, 19, 22, 23]. Results of our study demonstrated that lower vitamin D levels were significantly correlated with higher fasting glucose levels and HOMA index ( r = −0.369, P = 0.031 and r = −0.480, P = 0.035).…”

Section: Discussionsupporting

confidence: 57%

Cardiometabolic Risk Factors Related to Vitamin D and Adiponectin in Obese Children and Adolescents

Kardaş

Kendirci

Kurtoğlu

2013

International Journal of Endocrinology

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Obesity-related diseases are becoming the most important causes of mortality worldwide. Several studies have suggested an association between low levels of vitamin D and obesity. In addition, plasma adiponectin levels have been found to be lower in obese subjects. We evaluated the association of metabolic risk factors with both adiponectin and vitamin D levels and that between adiponectin and vitamin D levels. The study consisted of 114 obese and healthy subjects. 25-Hydroxy vitamin D [25(OH)D] levels were positively correlated with adiponectin and HDL-cholesterol (HDL-C) and inversely correlated with body mass index (BMI), LDL-cholesterol (LDL-C), total cholesterol (T-C), triglyceride (TG), fasting glucose, homeostasis model assessment of insulin resistance (HOMA index), systolic blood pressure (SBP), and diastolic blood pressure (DBP). The mean 25(OH)D levels in the obese and nonobese groups were 22.5 ± 5.7 and 32.3 ± 5.8 ng/mL, respectively (P < 0.0001). The mean adiponectin level in the obese group was lower than that in the nonobese group (P < 0.0001). Lower vitamin D and adiponectin levels were strongly associated with metabolic risk factors and obesity in Turkish children and adolescents.

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Section: Discussionsupporting

confidence: 57%

Cardiometabolic Risk Factors Related to Vitamin D and Adiponectin in Obese Children and Adolescents

Kardaş

Kendirci

Kurtoğlu

2013

International Journal of Endocrinology

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“…Interestingly the vitamin D level was significantly higher at the end of the sunny season than in the summer season itself. The vitamin D levels reported by this study were taken in Lebanon at latitude 33°N and were lower than the ones reported by Greer in Australia (latitude 29°S) and by Littorin in Sweden (latitude 55–65°N) 19,20. It seems that vitamin D levels in our study are affected by factors relevant to developing countries21 rather than purely on geographical/solar distribution considerations 22.…”

Section: Discussioncontrasting

confidence: 75%

Seasonal variation of vitamin D and HbA1c levels in patients with type 1 diabetes mellitus in the Middle East

Baba

Zantout²,

Akel³

et al. 2011

IJGM

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IntroductionThe discovery that many tissues express the vitamin D receptor and are able to transform the 25-hydroxyvitamin D into 1,25-dihydroxyvitamin D (active metabolite) has led to the hypothesis that vitamin D could have a role in the pathogenesis and prevention of diabetes mellitus. Accumulating evidence has linked vitamin D deficiency with immunological disturbance in type 1 diabetes mellitus. Several epidemiological studies have shown lower serum 25-hydroxyvitamin D concentrations in diabetic individuals compared to nondiabetic individuals.Patients and methodsA total of 105 Lebanese patients with type 1 diabetes mellitus were recruited. Levels of HbA1c and vitamin D were recorded during two phases with phase 1 being the period from June–September 2009 and phase 2 from January–April 2009.ResultsVitamin D levels at the end of sunny season (phase 2), reflecting the previous sunny months, were found to be higher than in the early summer season (phase 1) reflecting the previous cloudy months season, with a mean change of 0.70 ± 6.87 ng/mL (P = 0.029). HbA1c levels were higher in phase 2 than in phase 1 with an increase of 0.175% ± 1.46% (P = 0.113).ConclusionVitamin D levels were higher at the end of the sunny season than at the end of cloudy season. HbA1c was also lower (but not significantly so) in the early summer season (cloudy months). There was a weak correlation between seasonal changes of vitamin D levels and the control of blood glucose as monitored by HbA1c in a cohort of Lebanese patients with type 1 diabetes mellitus.

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“…NL has the lowest rates of initiation and duration of breastfeeding in Canada [16]; exclusive breastfeeding has been shown have a weak protective association with T1DM risk [17-19]. Vitamin D deficiency has been associated with increased risk of T1DM [20,21], vitamin D supplementation may be protective against T1DM [22] and UVB irradiation and northern latitude are also associated factors [23]. NL has a northern latitude (49°N) and erythemal UVB radiation may be geospatially associated with the incidence of T1DM NL [24].…”

Section: Discussionmentioning

confidence: 99%

Recent incidence of type 1 diabetes mellitus in children 0–14 years in Newfoundland and Labrador, Canada climbs to over 45/100,000: a retrospective time trend study

et al. 2012

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BackgroundTo study and update the provincial incidence of type 1 diabetes mellitus (T1DM) in Newfoundland and Labrador (NL), a province of Canada with a very high incidence previously reported in 2006, and one of the highest incidences reported worldwide. This is a retrospective time trend study of the incidence of T1DM, in children aged 0–14 years from 1987–2010 inclusive.FindingsOver the study period 931 children aged 0–14 years were diagnosed with T1DM. The incidence of T1DM in this population over the period 1987 – 2010 inclusive was 37.7 per 100,000 per year (95% CI 35. 3, 40.2)The incidence from 2007–2010 was 49.9 per 100,000 per year (95% CI 42.2, 57.6). The incidence over this 24 year period increased by a factor of 1.03 per 100,000 per year.ConclusionNL has one of the highest incidences of T1DM reported worldwide. Potential reasons for the very high incidence could be related to the unique genetic background of the population, northern latitude and vitamin D insufficiency, low breastfeeding rates, and high rates of cesarean section.

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Australian children and adolescents with type 1 diabetes have low vitamin D levels

Cited by 74 publications

References 5 publications

Cardiometabolic Risk Factors Related to Vitamin D and Adiponectin in Obese Children and Adolescents

Cardiometabolic Risk Factors Related to Vitamin D and Adiponectin in Obese Children and Adolescents

Seasonal variation of vitamin D and HbA1c levels in patients with type 1 diabetes mellitus in the Middle East

Recent incidence of type 1 diabetes mellitus in children 0–14 years in Newfoundland and Labrador, Canada climbs to over 45/100,000: a retrospective time trend study

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