Seasonal variation of vitamin D and HbA1c levels in patients with type 1 diabetes mellitus in the Middle East

Baba, Khaled El; Zantout, Mira S.; Akel, Reem; Azar, Sami T.

doi:10.2147/ijgm.s23548

Cited by 11 publications

(7 citation statements)

References 23 publications

(24 reference statements)

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“…Similarly, no significant differences in parameters studied in diabetics and controls were detected in Denmark [92]. In a Lebanese T1D population, El Baba et al showed seasonal variation in glucose control but failed to establish a significant correlation between seasonal changes in 25-OH D levels and HbA1c [93, 94]. In fact, ethnicity may be a confounding factor [95].…”

Section: Seasonal Variability In the Incidence Of T1dmmentioning

confidence: 99%

The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

Chakhtoura

Azar

2013

International Journal of Endocrinology

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The “nonclassic” role of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been recently widely recognized. In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role through the vitamin D receptor (VDR) present on pancreatic and immune cells. Specific VDR allelic variants have been associated with T1D in many countries. Furthermore, vitamin D deficiency has been prevalent in T1D, and the seasonal and latitude variability in the incidence of T1D can be partly explained by the related variability in vitamin D level. In fact, retrospective studies of vitamin D supplementation during pregnancy or infancy showed a lower incidence of T1D. We will review the different mechanisms of the vitamin D protective effect against insulitis and present the available data on the role of vitamin D deficiency in the control, progression, and complications of T1D.

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Section: Seasonal Variability In the Incidence Of T1dmmentioning

confidence: 99%

The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

Chakhtoura

Azar

2013

International Journal of Endocrinology

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“…In contrast, a study by El Baba showed no significant relationship between glycemic control and variation of vitamin D level. 30 Vitamin D deficiency may contribute to the development of insulin resistance and the impairment of the secretion of insulin. 31 Vitamin D reduces the excessive release of insulin (in reaction to increased blood sugar) by decreasing insulin resistance.…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin D supplementation on HbA1c level in a cohort of type 1 diabetic patients

Ahmed¹,

Chalabi

2021

Zanco J. Med. Sci.

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Background and objective: Glycemic control is essential to halt the progression of diabetic complications. Some studies previously showed the effect of vitamin D on pancreatic β-cell function and insulin secretion. This study aimed to assess the effect of vitamin D supplementation on HbA1c in patients with type 1 diabetes and vitamin D deficiency. Methods: This prospective quasi-experimental study was conducted in Erbil city from 1st September to 1st December 2019. In this study, 76 patients attending Layla Qasim diabetic center were tested. Only 50 patients were recruited that had vitamin D deficiency (25OHD: <20) and were aged less than 18 years. They received vitamin D supplementation for 12 weeks. HbA1c and vitamin D level was measured before and after supplementation. Results: Before vitamin D supplementation, the mean level of serum 25(OH)D among females (8.67 ± 2.56) was lower than males (14.31 ± 3.19). However, no association was found between the initial HbA1c level and gender. HbA1c level (mean = 8.24 ± 0.49) improved significantly after vitamin D supplementation to the level of 7.93 ± 0.67 (P = 0.032). There was a significant difference between groups of glycosylated hemoglobin levels of (first tertile<7.5%, second tertile 7.6%-9.9%, third tertile ≥10%) after 12 weeks of supplementation with vitamin D (P <0.001). Conclusion: Vitamin D supplementation in type 1 diabetic patients with vitamin D deficiency lead to significant improvement in HbA1c level. Keywords: Diabetes; Deficiency; Vitamin D.

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“…During exposure to sunlight, the solar UVB photons with 290- to 315-nm wavelengths are absorbed by 7-dehydrocholesterol in the skin, which is then converted into previtamin D which is converted by a thermal reaction into vitamin D. Since there are seasonal variations in UVB exposure, 25(OH)D serum concentrations can accordingly vary, i.e. adequate 25(OH)D concentrations in the summer and the beginning of fall but suboptimal concentrations in winter and spring [22,23,24]. To confirm this assumption, Bolland et al [25] conducted a cross-sectional study evaluating healthy older men and postmenopausal women living in New Zealand, showing seasonal (and latitudinal) variations in 25(OH)D concentrations.…”

Section: Determinants Of 25(oh)d Homeostasismentioning

confidence: 99%

Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes

et al. 2012

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Recent compelling evidence suggests a role of vitamin D deficiency in the pathogenesis of insulin resistance and insulin secretion derangements, with a consequent possible interference with type 2 diabetes mellitus. The mechanism of this link is incompletely understood. In fact, vitamin D deficiency is usually detected in obesity in which insulin resistance is also a common finding. The coexistence of insulin resistance and vitamin D deficiency has generated several hypotheses. Some cross-sectional and prospective studies have suggested that vitamin D deficiency may play a role in worsening insulin resistance; others have identified obesity as a risk factor predisposing individuals to exhibit both vitamin D deficiency and insulin resistance. The available data from intervention studies are largely confounded, and inadequate considerations of seasonal effects on 25(OH)D concentrations are also a common design flaw in many studies. On the contrary, there is strong evidence that obesity might cause both vitamin D deficiency and insulin resistance, leaving open the possibility that vitamin D and diabetes are not related at all. Although it might seem premature to draw firm conclusions on the role of vitamin D supplementation in reducing insulin resistance and preventing type 2 diabetes, this manuscript will review the circumstances leading to vitamin D deficiency and how such a deficiency can eventually independently affect insulin sensitivity.

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Seasonal variation of vitamin D and HbA1c levels in patients with type 1 diabetes mellitus in the Middle East

Cited by 11 publications

References 23 publications

The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

Effect of vitamin D supplementation on HbA1c level in a cohort of type 1 diabetic patients

Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes

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