The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

Chakhtoura, Marlene; Azar, Sami T.

doi:10.1155/2013/148673

Cited by 70 publications

(54 citation statements)

References 117 publications

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“…These results are similar to the recent changes in epidemiology of T1D worldwide [1,2,12,13]. Several factors have been proposed to account for the increasing disease frequency and include accelerated autoimmunity [14] and probable triggers of autoimmunity like viruses [2,12,15] and vitamin D deficiency [16,17]. Other factors like gut microbial flora [18], psychological stress, climatic influences, and environmental toxins may also modify the disease process [2,12].…”

Section: Discussionsupporting

confidence: 83%

Hospital based incidence, patterns of presentation and outcome of type 1 diabetes: 12 years’ data from a tertiary care center in North India

Dayal

Saini

Jayashree

et al. 2015

Int J Diabetes Dev Ctries

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Increase in the incidence of Type 1 diabetes (T1D) over last several decades has been reported worldwide. There is a dearth of data on incidence/prevalence of T1D in children from India. We studied the trends in incidence of T1D amongst children attending a tertiary care pediatric hospital of North India over last 12 years and the changes in incidence, patterns of presentation and disease outcomes during this period by retrospective analysis of patient records and hospital census data. The study population comprised of 647 children with onset of T1D below 16 years who attended the hospital from April, 2001 to March, 2013. There was a consistent increase in the total number of T1D patients every year. The increase in the proportion of younger (<5 years) patients (16.2 % in 2001-02 versus 35.2 % in 2012-13) was significantly more as compared to other age categories. The percentage of patients who presented with DKA decreased every year (65 % in 2001-02 to 36.3 % in 2012-13). Younger (<5 years) patients were two to three times more likely to present in DKA than older (>15 years) patients (mean yearly percentage 60.3 versus 25 %). The proportion of patients presenting during winter months was almost double than the average of any of the 3 seasons (39 versus 20.3 %). The overall mortality was 1.7 %. In conclusion, the number of patients with T1D has shown an increase although the severity of presentation has declined. Marked seasonality in presentation indicates some unidentified environmental factors triggering the onset of disease in our patient population.

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Section: Discussionsupporting

confidence: 83%

Hospital based incidence, patterns of presentation and outcome of type 1 diabetes: 12 years’ data from a tertiary care center in North India

Dayal

Saini

Jayashree

et al. 2015

Int J Diabetes Dev Ctries

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“…На уровне иммунной системы 1,25(ОН) 2 D препятствует созреванию антигенпрезентирующих клеток, оказывает проапопто-тическое действие на дендритные клетки, в результате чего нарушается инициация иммунного ответа. С другой стороны, 1,25(ОН) 2 Dпредотвращает цитокининдуциро-ванный апоптоз β-клеток за счет повышения экспрессии протеина А20, снижающего продукцию NO [36]. Также в крупном мета-анализе показана роль полиморфизма гена VDR, более высокий риск развития сахарного диа-бета 1 типа отмечен у носителей аллеля BsmI [37].…”

Section: витамин D и иммунная функцияunclassified

“…Кроме того, показано улучшение контроля гликемии и уменьшение необходимых доз инсулина при присо-единении к инсулинотерапии кальцитриола. Однако для формулировки рекомендаций необходимо проведе-ние РКИ с длительным периодом наблюдения [36].…”

Section: витамин D и иммунная функцияunclassified

Non-classical effects of vitamin D

et al. 2018

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Остеопороз и остеопатии / Osteoporosis and Bone Diseases | 90 REVIEW ВВЕДЕНИЕФактор, недостаточность которого приводит к раз-витию рахита, был открыт и назван витамином D око-ло 100 лет назад; на протяжении прошедшего с тех пор времени было получено множество данных, свидетель-ствующих о том, что это вещество не только необхо-димо для нормального развития и функционирования костной ткани, но и является гормоном, опосредующим разнообразные эффекты в других тканях организма. В связи с этим значительный интерес представляет подробное изучение физиологической роли витами-на D в организме, его значения в функционировании тканей и органов, а также вклада, который вносит из-менение его метаболизма в развитие хронических за-болеваний, течение и исход беременности. Достижение специфических для отдельных тканей результатов при коррекции уровня витамина D ставит вопрос о возмож-ной целесообразности проведения профилактических и терапевтических мероприятий при соответствующих состояниях. ОСОБЕННОСТИ МЕТАБОЛИЗМА ВИТАМИНА D, РЕЦЕПТОРА ВИТАМИНА D, ВИТАМИН D-СВЯЗЫВАЮЩЕГО БЕЛКАВитамин D3 (колекальциферол) образуется в коже из 7-дегидрохолестерола в два этапа. На первом этапе под действием УФ-излучения (280-320 нм) образуется пре-витамин D3, который изомеризуется в D3 в резуль-тате термочувствительного, но некаталитического про-цесса. Витамин D может быть также получен из пищи, растительной (D2, или эргокальциферол) или животной (D3). В большинстве продуктов, за исключением жирных сортов рыбы, содержится незначительное количество витамина D. Since the discovery of vitamin D, interest in role of vitamin D in human body is consistently growing, and there is increasing evidence that vitamin D is not only essential to bone health but may also be involved in physiology of many other tissues. Thus understanding of its aspects in particular tissues appears to be important because of possible contribution to pathophysiologic processes. Intracrine regulatory systems associated with widely expressed vitamin D metabolizing enzymes, ways of cellular intake and signal pathways involved are of particular interest. Association of local effects with vitamin D level in blood is under investigation on animal models as well as in clinical studies; values of vitamin D level that mediate extraskeletal effects should be determined. In this review, we discuss impact of vitamin D on immune function and its association with skin, nervous system, cardiovascular system, obesity and diabetes mellitus, cancer, reproductive function, prevention of falls and quality of life improvement. НЕКЛАССИЧЕСКИЕ ЭФФЕКТЫ ВИТАМИНА D NON-CLASSICAL EFFECTS OF VITAMIN D

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“…Many studies were conducted in various countries to determine the effect of vitamin D 3 supplementation on levels of 25(OH)D 3 , IL-2, and C-peptide in children with T1DM. The results obtained are still varied and still cause controversy [15,16]. Current research on the effect of vitamin D3 supplementation on levels of 25(OH)D 3 , IL-2, and C-peptide in children with T1DM is not present in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

Cited by 70 publications

References 117 publications

Hospital based incidence, patterns of presentation and outcome of type 1 diabetes: 12 years’ data from a tertiary care center in North India

Hospital based incidence, patterns of presentation and outcome of type 1 diabetes: 12 years’ data from a tertiary care center in North India

Non-classical effects of vitamin D

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

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