Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice

Fang, Donglu; Wang, Dan; Ma, Gaoxing; Ji, Yang; Zheng, Huihua; Chen, Hui; Ren, Ang; Hu, Qiuhui; Zhao, Liyan

doi:10.1016/j.fshw.2021.04.005

Cited by 23 publications

(13 citation statements)

References 54 publications

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“…The gut microbiota composition can be reshaped through the interaction between intestinal microorganisms and dietary components [24]. More and more evidence shows that HFD leads to a decline in community richness [25], which may be due to the lack of healthy microflora induced by HFD [26]. In the current study, HFD feeding led to significantly decreased community richness, which was reversed by adzuki bean supplementation (Figure 5A,B).…”

Section: Discussionsupporting

confidence: 52%

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Zhao

Hou

et al. 2021

Nutrients

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Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. It also mitigated liver function damage and hepatic steatosis. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. In addition, it significantly reversed HFD-induced gut microbiota imbalances. Adzuki bean significantly reduced the ratio of Firmicutes/Bacteroidetes (F/B); enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium; and returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine; and LPS biosynthesis; and valine, leucine, and isoleucine degradation.

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Section: Discussionsupporting

confidence: 52%

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Zhao

Hou

et al. 2021

Nutrients

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“…Accumulation of lipid droplets in liver tissue can lead to changes in liver structure and function, resulting in elevated liver TG levels and impaired lipid metabolism, eventually leading to hyperlipidemia . Thus, hyperlipidemia can be caused by defects in lipid metabolism . In this study, long-term HFD intake was found to cause disturbances in lipid metabolism in mice, but interventions with CGA, EBE, and ELE reversed this phenomenon.…”

Section: Discussionmentioning

confidence: 54%

“…16 Researchers believe that gut microbiota plays a crucial role in the development of hyperlipidemia. 17 They believe that changes in the gut flora may affect energy uptake in hyperlipidemic patients. 18 These changes are often manifested by lower microbial diversity in individuals with obesity than that in thin individuals.…”

Section: Introductionmentioning

confidence: 99%

Eucommia Bark/Leaf Extract Improves Lipid Metabolism Disorders by Affecting Intestinal Microbiota and Microbiome–Host Interaction in HFD Mice

Wang

Yao

Sun

et al. 2023

J. Agric. Food Chem.

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Eucommia bark contains many bioactive compounds and has anti-hyperlipidemic effects. However, due to the slow growth rate of the plant, there is a limited supply of this resource. Studies have demonstrated that Eucommia leaves contain active ingredients similar to those of Eucommia bark and also have anti-hyperlipidemic effects. It is not currently clear whether Eucommia leaf can be used as a substitute for Eucommia bark. Furthermore, their mechanism of action for anti-hyperlipidemia by improving the structure of the gut microbiota is also unclear. We aimed to determine the composition of the active ingredients in EBE and ELE by HPLC, establish an HFD-induced hyperlipidemia model, and combine fecal microbiota transplantation (FMT) experiments to investigate the mechanism of EBE/ELE anti-hyperlipidemia by modifying the structure of intestinal microbiota, as well as to compare the effects of EBE and ELE. Our results showed that EBE and ELE contained similar active ingredients and significantly alleviated lipid metabolism disorders and blood glucose levels in the HFD-induced hyperlipidemia model. In this study, EBE and ELE significantly reduced the relative abundance of Desulfovibrionaceae and Erysipelotrichaceae and significantly increased the relative abundance of Ruminococcaceae. They also promoted the production of short-chain fatty acids (SCFAs) and activated the gene expression of the SCFA receptors G protein-coupled receptor 41 (GPR41) and GPR43. In addition, EBE and ELE can significantly increase the expression of the fasting-induced adipose factor (Fiaf) gene in the colon and inhibit the secretion of lipoprotein lipase (LPL) in the liver, thereby inhibiting triglyceride (TG) synthesis. They also significantly activate the expression of GPR41 and GPR43 genes in the epididymal fat tissue, leading to reduced lipid accumulation in adipocytes. These effects on the target genes were associated with changes in the abundance of Desulfovibrionaceae, Erysipelotrichaceae, and Ruminococcaceae bacteria in the intestinal microbiota. Thus, regulating the relative abundance of these microbes may serve as prospective targets for EBE/ELE to influence the Fiaf-LPL gut-liver axis and the SCFAs-GPR41/GPR43 gut-fat axis. In addition, there was no significant difference in the antihyperlipidemic effects of ELE and EBE, suggesting that Eucommia leaf may be a suitable alternative to Eucommia bark for managing hyperlipidemia by regulating the structure of the intestinal microbiota. These findings suggest that Eucommia leaves have great potential for development as a functional food with lipid-lowering properties.

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“…Previous study had shown that obese mice have higher serum TC, TG and LDL-C levels, but lower serum HDL-C levels, which is consistent with the serum results of our study ( Xu et al, 2022 ). Higher levels of blood glucose, serum TC and TG may promote the occurrence and development of atherosclerosis ( Guo et al, 2018 ; Fang et al, 2021 ). Serum LDL-C overload is one of the main factors leading to lipid metabolism disorder, which further induces apoptosis and inflammatory response ( Li et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Intestinal microbiomics and liver metabolomics insights into the preventive effects of chromium (III)-enriched yeast on hyperlipidemia and hyperglycemia induced by high-fat and high-fructose diet

Wang

Guo

Yang

et al. 2022

Current Research in Food Science

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Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice

Cited by 23 publications

References 54 publications

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Eucommia Bark/Leaf Extract Improves Lipid Metabolism Disorders by Affecting Intestinal Microbiota and Microbiome–Host Interaction in HFD Mice

Intestinal microbiomics and liver metabolomics insights into the preventive effects of chromium (III)-enriched yeast on hyperlipidemia and hyperglycemia induced by high-fat and high-fructose diet

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