Intestinal microbiomics and liver metabolomics insights into the preventive effects of chromium (III)-enriched yeast on hyperlipidemia and hyperglycemia induced by high-fat and high-fructose diet

Wang, Meiting; Guo, Weiling; Yang, Ziyi; Chen, Feng; Lin, Tiantian; Li, Wenlong; Lv, Xu-Cong; Rao, Pingfan; Ai, Lianzhong; Ni, Li

doi:10.1016/j.crfs.2022.08.015

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…Cr supplementation inhibits the activities of α-amylase and α-glucosidase, exerting a beneficial effect on postprandial blood glucose ( 28 , 29 ). In animal models of metabolic syndrome and T2DM, Cr supplementation inhibited hepatic gluconeogenesis by decreasing mRNA expression of fructose 1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase) and promoted hepatic glycogen synthesis by upregulating glucokinase (Gk) mRNA expression in the liver ( 32 – 34 ). In addition, Cr reduced the expression of CD36 in liver tissue and SMMC-7721 cells, thus decreasing the uptake of exogenous fatty acids, while increasing the levels of liver type fatty acid binding protein (L-FABP) mRNA in liver tissue, promoting fatty acid transport across cell membranes and into mitochondria, which enhanced hepatic fatty acid utilization ( 8 , 33 – 36 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Cr enhances cholesterol metabolism. In Kunming mice with metabolic syndrome, Cr supplementation promoted cholesterol transport and metabolism by upregulating the mRNA expression of apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR) and suppressed cholesterol synthesis by upregulating cytochrome P450 7A1 (CYP7A1) mRNA expression ( 32 , 33 ). Finally, recent studies suggest that Cr supplementation significantly alteres the gut microbiome in animal models of T2DM and metabolic syndrome, leading to the improvement of glucose and lipid metabolism and the inhibition of liver lipid accumulation by the “gut-liver axis” ( 32 – 34 ).…”

Section: Discussionmentioning

confidence: 99%

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Association between blood chromium and hepatic steatosis assessed by liver ultrasound transient elastography: National Health and Nutrition Examination Survey 2017–2020

Xiang,

Zhou,

Wang

et al. 2024

Front. Nutr.

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BackgroundHepatic steatosis is a significant pathological feature of fatty liver disease (FLD) which is widely spread with no effective treatment available. Previous studies suggest that chromium (Cr) intake reduces lipid deposition in the liver in animals. However, the connection between blood Cr and hepatic steatosis among humans remains inconclusive.MethodsUsing the data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020, we performed a cross-sectional analysis, including 4,926 participants. The controlled attenuation parameter (CAP) measured by the vibration controlled transient elastography (VCTE) was used to evaluate the degree of liver steatosis. Weighted univariate regression, multivariate linear regression, smooth fitting curves and subgroup analysis were used. In addition, we carried out trend tests, multiple interpolations, and interaction analyses to conduct sensitivity analyses.ResultsAfter adjusting with various covariables, multivariate linear regression analysis demonstrated a significant negative correlation between blood Cr and CAP [β (95% CI) = −5.62 (−11.02, −0.21)]. The negative correlation between blood Cr and CAP was more significant in the males, 50–59 years, overweight, hypercholesterolemia, HDL-C ≥ 65 mg/dL, HbA1c (5.70–6.10 %), HOMA-IR (0.12–2.76), total bilirubin (0.30–0.40 mg/dL), ever alcohol consumption subjects. Of note, the relationships between blood Cr and CAP followed a U-shaped curve in the smokers and non-smokers, with blood Cr thresholds of 0.48, 0.69 μg/L, respectively.ConclusionsThere is an independently negative correlation between blood Cr and hepatic steatosis in American. Our study provides clinical researchers with a new insight into the prospective prevention of hepatic steatosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between blood chromium and hepatic steatosis assessed by liver ultrasound transient elastography: National Health and Nutrition Examination Survey 2017–2020

Xiang,

Zhou,

Wang

et al. 2024

Front. Nutr.

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“…The main manifestation of fat metabolism in obesity is a general increase in blood lipid components such as TG, TC, LDL‐C, AST and ALT. Persistent hyperlipidaemia is positively correlated with abnormal lipid accumulation in the liver, ultimately leading to obesity (Wang et al ., 2022). In this study, HFD + M and HFD + H interventions significantly improved serum and liver lipid levels, liver tissue morphology and liver lipid droplet count in obese mice ( P < 0.001) (Figs 2 and 3).…”

Section: Discussionmentioning

confidence: 99%

Effects of the composition of food and medicine homologous ingredients complex supplementation on lipid metabolism and gut microbiota diversity in high‐fat diet‐induced obese mice

Ma,

Cui,

Wang

et al. 2024

Int J of Food Sci Tech

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SummaryDietary patterns are closely related to obesity, and a balanced diet can prevent obesity more than a single food or nutrient. In this study, we investigated the anti‐obesity effects of food and medicine homologous ingredient complex (FMHIC). The serum biochemical indices related to lipid metabolism were significantly improved in the FMHIC group. Meanwhile, it significantly inhibited the accumulation of lipid droplets, improved adipocyte hypertrophy and downregulated gene expression related to lipid production. FMHIC can effectively regulate intestinal flora richness and structural disorder in obese mice and result in a higher abundance of NK4A214_group and Prevotellaceae _UCG_001, and a lower abundance of Negativibacillus, Lachnospiraceae_NK4A136_group, Lachnoclostridium and GCA_900066575. Spearman correlation analysis showed that there was a strong correlation between species richness and lipid metabolism and that FMHIC might adjust lipid metabolism by regulating the abundance of intestinal flora. In conclusion, FMHIC regulates lipid metabolism and modulates gut microbiota to regulate high‐fat diet‐induced dysbiosis.

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“…[3,4] The carcinogenic, mutagenic, and non-biodegradable Cr(VI) finds its way into drinking water systems through leakages or unqualified disposals from anthropogenic activities such as metal finishing, leather tanning, and electroplating, among others. [5][6][7][8][9] To control its potential danger to humans and animals, the World Health Organization has set stringent laws for the maximum admissible amount of Cr(VI) in drinking water at 0.05 mg/L. [10,11] Numerous strategies have been applied to modulate Cr(VI) in water.…”

Section: Introductionmentioning

confidence: 99%

Reduction and Adsorption of Hexavalent Chromium by Iron Sulfide Loaded Biochar: Isotherms, Kinetics and Thermodynamics

Qhubu,

Lesaoana,

Nomngongo

et al. 2023

ChemistrySelect

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The removal of noxious Cr(VI) from water has gained worldwide attention. In this study, biochar derived from macadamia nut shells (MHP) was embedded with iron sulfide (FeS) nanoparticles produced through a solid‐phase reduction of pyrite. The MHP‐FeS composite was evaluated for the adsorption of Cr(VI) and its subsequent reduction to Cr(III). The scanning electron microscope images revealed that the particles were of irregular shape, while the energy dispersive spectroscopy results showed the existence of Fe, S, O, and C atoms. X‐ray diffraction peaks at 2=29.8°, 33.7°, 43.7°, and 53.1° were characteristic of the formation of FeS nanoparticles. A maximum Cr(VI) adsorption capacity of 4.95 mg/g was obtained at pH 3, 60 min, and 25 °C. The higher correlation coefficient (R2>0.873) and lower residual standard error (RSE=1.43) values pointed to the adsorption process favoring Langmuir and pseudo‐second‐order models. As per thermodynamic reaction calculations, the remediation process was spontaneous and endothermic. With further optimization, this material could be a potential adsorbent and reductant for Cr(VI) in water.

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Intestinal microbiomics and liver metabolomics insights into the preventive effects of chromium (III)-enriched yeast on hyperlipidemia and hyperglycemia induced by high-fat and high-fructose diet

Cited by 6 publications

References 67 publications

Association between blood chromium and hepatic steatosis assessed by liver ultrasound transient elastography: National Health and Nutrition Examination Survey 2017–2020

Association between blood chromium and hepatic steatosis assessed by liver ultrasound transient elastography: National Health and Nutrition Examination Survey 2017–2020

Effects of the composition of food and medicine homologous ingredients complex supplementation on lipid metabolism and gut microbiota diversity in high‐fat diet‐induced obese mice

Reduction and Adsorption of Hexavalent Chromium by Iron Sulfide Loaded Biochar: Isotherms, Kinetics and Thermodynamics

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