Atteintes rénales au cours de la drépanocytose

Cazenave, M.; Koehl, Bérengère; Nochy, Dominique; Tharaux, Pierre‐Louis; Audard, Vincent

doi:10.1016/j.nephro.2013.07.366

Cited by 10 publications

(1 citation statement)

References 63 publications

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“…This glomerular hyperfiltration was found in our study in subjects infected with HIV (38.5%), while in uninfected subjects, it was 5.1% (P = 0.00). Even though the literature is poor with regard to glomerular hyperfiltration in children infected with HIV, its mechanism remains the same as that found in glomerular nephropathy and even in diabetic nephropathy and sickle cell patients (20). It was, nevertheless, damage in HIV-infected children monitored at CHUD Borgou/Alibori in Parakou.…”

Section: Kidney Damagementioning

confidence: 95%

Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin)

Ahoui

Agbeille²,

Kpanidja³

et al. 2021

jrenhep

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The history of kidney disease associated with HIV infection dates back to the years of HIV breakthrough. The objective was to study kidney damage in children infected with HIV at the Teaching Hospital of Borgou (Benin) in 2019. This was a cross-sectional, descriptive, analytical, matching-type study carried out from June 1, 2019 to September 30, 2019 at the pediatrics department of Teaching Hospital of Borgou (Benin). The study included HIV-positive children, followed in consultations, and whose parents gave their consent. The biological markers were demon-strated with urine dipstick. Glomerular filtration rate was calculated using the Schwartz test and classified according to stages. The dependent variable was the presence of at least one impairment (biological or functional). Sample size was determined by Schwartz’s method on the basis of one case for two controls. Sociodemographic, clinical, biological, and therapeutic data were collected. Comparisons were made using the Chi-square test or Fisher’s exact test. The identification of associated factors was possible using a multiple logistic regression model at 5% threshold. In total, we included 117 children, including 39 HIV-positive children. The average age was 8 ± 4.81 years and the gender ratio was 1:17. The frequency of kidney damage was 76.5%. Permanent proteinuria and at least two crosses on urine dipstick were present in 20.5%, leukocyturia in 2.6%, and proximal tubular dysfunction in 5.1%. Glomerular hyperfiltration was found in 38.5%, acute kidney injury in 38.5%, and chronic kidney injury in 5.1%. Associated factors were age (P = 0.004), presence of opportunistic infections (P = 0.00), and treatment adherence (P = 0.004). Kidney damage is common in HIV-positive children. Careful follow-up is necessary to avoid complications.

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Section: Kidney Damagementioning

confidence: 95%

Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin)

Ahoui

Agbeille²,

Kpanidja³

et al. 2021

jrenhep

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Homozygous sickle cell disease related mortality in Senegal (2011–2020)

Seck

Faye

et al. 2021

eJHaem

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Homozygous sickle cell disease (HSCD) is characterized by multiorgan morbidity and an increased risk of early death. We aim to describe the mortality rate, causes, and risk factors of death in HSCD between 2011 and 2020. We conducted a retrospective study with a duration of 10 years in the cohort of 2348 HSCD patients. The mortality rate was determined by reporting the number of deaths to the total number of patients followed in the year. Sociodemographic, clinical, biological data and causes of death were studied. Death risk factors were determined by a bivariate analysis comparing deceased and living HSCD patients. The mean age of death was 26 years (3–52). The sex ratio was 1.2. The mortality rate was 2.76%. The death rate was high in 2011 (3.2%) and low in 2020 (0.17%). We observed a significant reduction of mortality of 94.6%. Most of the common causes of death were acute anemia (40%), acute chest syndrome (24.6%), and infections (20%). Risk factors of death were age, vaso‐occlusive crises ≥3, acute chest syndrome, blood transfusion, and chronic complications. Mortality among HSCD has significantly decreased over the past 10 years in Senegal, and the main causes of death were acute anemia, acute chest syndrome, and infections.

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Evaluation of Genetic Kidney Disease in Living Donor Candidates

Thomas

Divers

2021

Living Kidney Donation

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Atteintes rénales au cours de la drépanocytose

Cited by 10 publications

References 63 publications

Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin)

Kidney Injury in Children Infected with HIV, Followed at the Teaching Hospital of Borgou (Benin)

Homozygous sickle cell disease related mortality in Senegal (2011–2020)

Evaluation of Genetic Kidney Disease in Living Donor Candidates

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