Asymmetric membrane-based potentiometric solid-state ion sensors

A Breakthrough Application of a Cross-Linked Polystyrene Anion-Exchange Membrane for a Hydrogencarbonate Ion-Selective Electrode

“…Although its suitability is well proved, ongoing research aims to take advantage of other polymers to reduce or eliminate plasticizer leaching, to improve biocompatibility, to improve sensor performance, its response time, selectivity, and detection limit. For these reasons, many other polymers have been tested, namely viscose cellulose, silicone rubber, cellulose acetate, acrylic polymers and polyurethanes [4,6,10,11,12,13,14,15].…”

Chemical Modification of Polymer Ion‐Selective Membrane Electrode Surfaces

“…Another report, however, states that in some cases it is possible to hydrolyze the plasticized ion‐selective CTA membrane without a loss of its properties 89. This direct hydrolysis of plasticized CTA membrane was proposed as a promising strategy to design all solid state electrodes 89, 90, however, a weak adhesion of CTA to the electrode substrate needs to be addressed first 90.…”

“…Polyurethanes were introduced as an alternative to PVC to improve membrane adhesion, biocompatibility and to reduce plasticizer use 3, 4, 9, 11, 90, 92, 98–105. Common commercial PUs used as ISE membrane material are aliphatic Tecoflex and characterized with a high biocompatibility silicon‐modified segmented polyurethane Biospan‐S (Figure 7).…”

“…This material was used in conjunction with an NO releasing polymer in the underlying layer as an endothelium mimicking surface, thereby significantly reducing platelet adhesion. Although the intended purpose of these modifications was for biomedical devices rather than ion sensors, other reports on successful application of polyurethanes as an ISE matrix 3, 4, 9, 11, 90, 92, 98–105, NO releasing sensors 14 and heparin modified membranes 15, 16 allows one to expect that this synergic approach could be adopted also to the ISE field.…”

Measuring permeability with a whole cell-based biosensor as an alternate assay for angiogenesis: Comparison with common in vitro assays

“…Various studies have reported that functional membrane ISEs can be prepared from hydrolyzed asymmetric CTA with valinomycin ionophore (Cha and Meyerhoff, 1989;Cha et al, 1995;Brooks et al, 1996;Sakong et al, 1996) The hydroxyl groups present on the outer surface of the base layer facilitate further surface modification and biomolecule attachment (Cha and Meyerhoff, 1989;Brooks et al, 1996;Koncki et al, 1997). The RGD modified CTA membrane was prepared as described previously (May et al, 2004).…”