Chemical Modification of Polymer Ion‐Selective Membrane Electrode Surfaces

Pawlak, Marcin; Bakker, Eric

doi:10.1002/elan.201300449

Cited by 30 publications

(24 citation statements)

References 114 publications

(164 reference statements)

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“…During the past decades, several strategies have been proposed to improve the biocompatibility of polymeric membrane ISEs in order to make them reliable for continuous blood sample analysis and even the eventual monitoring in vivo. 10 These attempts have made great contributions toward the improvement of the biocompatibility, but the developed sensors are usually involved with complicated synthesis processes or unstable surface modification layers. This poses serious limits to their wide use, especially for long-term in vivo monitoring.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Improving the Biocompatibility of Polymeric Membrane Potentiometric Ion Sensors by Using a Mussel-Inspired Polydopamine Coating

et al. 2019

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Polymeric membrane potentiometric ion sensors have been widely used in clinical diagnosis for the detection of electrolyte ions and account for billions of measurements every year throughout the world. However, in many cases of practical relevance, biofouling, which might lead to sensor failure, usually occurs due to the lack of biocompatibility of these sensors. Herein, we describe a simple and robust approach for improving the biocompatibility of the polymeric ionselective membranes. A marine mussel-inspired polydopamine polymer is used as a hydrophilic coating on the surface of conventional potentiometric ion sensors. Such a coating can be easily formed by self-polymerization of dopamine and robustly deposited on the sensor surface mimicking the adhesion mechanism of mussels. The classical poly(vinyl chloride) membrane-based calcium ion-selective electrode (ISE) is chosen as a model. Compared to the unmodified Ca 2+ ISE, the polydopamine modified electrode shows a significantly reduced blood platelet adsorption while retaining original potentiometric ion response properties, which clearly indicates a high antifouling capability induced by the hydrophilic polydopamine coating. We believe that the proposed approach can provide an appealing way to improve the biocompatibility in the development of polymeric membrane electrochemical and optical sensors.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Improving the Biocompatibility of Polymeric Membrane Potentiometric Ion Sensors by Using a Mussel-Inspired Polydopamine Coating

et al. 2019

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“…Schaubroeck et al have shown that addition of amine groups to dielectric resins improves the adhesion with electrochemically deposited metals (Figure c) . Treatment of polymer surfaces with strong electron affinity groups, such as fluorine via solution reactions or chemical vapor treatments enhances their electron acceptance . The triboelectric polarities of polymers are enhanced with selective functionalization with positively and negatively charged reactive species which are covalently bonded to the polymer surface (Figure b).…”

Section: Chemical Treatment On Polymersmentioning

confidence: 99%

Surface Modification of Polymers: Methods and Applications

Nemani

Annavarapu

Mohammadian

et al. 2018

Adv Materials Inter

252

161

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Low cost, controlled crystallinity, chemical, and mechanical stability enable application of polymers in energy, water, electronics, and biomedical industries. Recent studies have shown that tailoring surface properties of polymers impacts their durability and functionality in these applications. However, the functionality and performance of polymer‐based devices and systems are greatly affected by the modification method and the process parameters, highlighting the need for understanding these methods and their mechanisms of operation in detail. The selection of the modification method invariably decides the properties enhanced in the polymer. In this review, various polymer surface modification treatments are discussed. These methods are categorized into physical, chemical, thermal, and optical ways, while illustrating their advantages and disadvantages. This review also explores the surface modification of polymers by patterning which encompasses one or more surface treatment methods. An application‐oriented study is presented discussing the relative importance of a method pertaining to a specific field of end‐application.

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“…Reports on haemocompatible sensor surfaces still indicate a continued quest for the single 'magic bullet' solution where none may exist. Nevertheless, general rules may be derived from such studies, such as general rules for hydrophobic/hydrophilic balance for lowered fouling and specific surface chemical motifs that link to complement activation [43]. The surface protein profile together with its later remodeled form [44] presents the real final contact layer for all the subsequent cellular processes organised by blood.…”

Section: Protein Surface Interactionsmentioning

confidence: 99%

Monitoring with In Vivo Electrochemical Sensors: Navigating the Complexities of Blood and Tissue Reactivity

Vadgama

2020

Sensors

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The disruptive action of an acute or critical illness is frequently manifest through rapid biochemical changes that may require continuous monitoring. Within these changes, resides trend information of predictive value, including responsiveness to therapy. In contrast to physical variables, biochemical parameters monitored on a continuous basis are a largely untapped resource because of the lack of clinically usable monitoring systems. This is despite the huge testing repertoire opening up in recent years in relation to discrete biochemical measurements. Electrochemical sensors offer one of the few routes to obtaining continuous readout and, moreover, as implantable devices information referable to specific tissue locations. This review focuses on new biological insights that have been secured through in vivo electrochemical sensors. In addition, the challenges of operating in a reactive, biological, sample matrix are highlighted. Specific attention is given to the choreographed host rejection response, as evidenced in blood and tissue, and how this limits both sensor life time and reliability of operation. Examples will be based around ion, O2, glucose, and lactate sensors, because of the fundamental importance of this group to acute health care.

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Chemical Modification of Polymer Ion‐Selective Membrane Electrode Surfaces

Cited by 30 publications

References 114 publications

Improving the Biocompatibility of Polymeric Membrane Potentiometric Ion Sensors by Using a Mussel-Inspired Polydopamine Coating

Improving the Biocompatibility of Polymeric Membrane Potentiometric Ion Sensors by Using a Mussel-Inspired Polydopamine Coating

Surface Modification of Polymers: Methods and Applications

Monitoring with In Vivo Electrochemical Sensors: Navigating the Complexities of Blood and Tissue Reactivity

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