Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats

Sila, Assaâd; Ghlissi, Zohra; Kamoun, Zeineb; Makni, Mohamed; Nasri, Monçef; Bougatef, Ali; Sahnoun, Zouheir

doi:10.1007/s00394-014-0711-2

Cited by 71 publications

(59 citation statements)

References 32 publications

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“…It was demonstrated that astaxanthin not only binds to this receptor but also affects its mRNA expression [19]. In agreement, the antihyperglycemic effect of astaxanthin is reported elsewhere [20,21]. However, in contrast to these findings, Chen and colleagues reported that astaxanthin, despite its protective effects on kidney and liver of the diabetic rats, did not modify hyperglycemia [22].…”

Section: Carotenoids Intake and The Incidence Of Diabetes Mellitusmentioning

confidence: 51%

Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

Roohbakhsh

Karimi

Iranshahi

2017

Biomedicine & Pharmacotherapy

115

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Section: Carotenoids Intake and The Incidence Of Diabetes Mellitusmentioning

confidence: 51%

Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

Roohbakhsh

Karimi

Iranshahi

2017

Biomedicine & Pharmacotherapy

115

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“…Data from clinical trials suggest that ATX supplementation might prevent oxidative damage in smokers by suppressing lipid peroxidation and stimulating the activity of the antioxidant system [23]. In rats with diabetic nephropathy, shrimp ATX exerts an important role in the reduction of oxidative damage and in preventing pathological changes; it also attenuates diabetes-associated coagulatory and inflammatory stress [15,24]. All these data suggest a promising application of ATX in CKD treatment.…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis

Liu¹,

Shi²,

Peng

et al. 2015

Pharmacology

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Background/Aim: Focal segmental glomerulosclerosis (FSGS) is a specific pattern of chronic renal injury with progressive glomerular scarring. The phenotypic alterations that contribute to FSGS include inflammatory response and oxidative stress. Astaxanthin (ATX) has a broad range of biological functions, particularly antioxidant and anti-inflammatory ones. This study was designed to evaluate the renoprotective effect of ATX treatment on Adriamycin-induced FSGS. Methods: In Balb/c mice, Adriamycin nephropathy was induced by Adriamycin (10 mg/kg body weight, diluted in normal saline) via a tail vein on day 0. Then the mice were treated with ATX (50 mg/kg body weight) once daily by oral gavage, again starting on the day of Adriamycin injection and continued for 6 weeks. At 6 weeks, the mice were sacrificed; kidneys and blood samples were collected for further analysis. Results: Animals that underwent intermittent exposure to ATX treatment exhibited significant improvements in renal functional parameters as well as in glomerular and interstitial fibrosis compared to those undergoing saline treatment in FSGS mouse models. ATX treatment exerted anti-inflammatory and antioxidant effects by promoting Nrf2 expression and suppressing renal nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation. Conclusion: ATX might offer a ray of hope for ameliorating FSGS.

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“…• and O 2 •− and reducing the cytosolic Ca 2+ [17].In diabetes, major damage occurs in tissues such as kidney, astaxanthin can protect cell damages in thediabetic kidney [18]. In the kidneys of astaxanthin fed diabetic mice, cells positive for 8-hydroxydeoxyguanosine(8-OHdG), an index of oxidative stress, were significantly decreased, thus leading to the prevention of diabetic nephropathy [15].…”

Section: Astaxanthin and Diabetesmentioning

confidence: 99%