Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

Roohbakhsh, Ali; Karimi, Gholamreza; Iranshahi, Mehrdad

doi:10.1016/j.biopha.2017.04.057

Cited by 116 publications

(80 citation statements)

References 114 publications

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“…To be transported in the body, lycopene must be incorporated into lipoprotein molecules. This process takes place in hepatocytes and intestinal epithelial cells and can be severely impaired with age, metabolic syndrome, and atherosclerosis (Borel et al., ; Diwadkar‐Navsariwala et al., ; Petyaev, ; Roohbakhsh et al., ). As result of this, even lycopene which has been absorbed cannot be incorporated into its lipoprotein carriers and people develop not a nutritional but a functional deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…To be transported in the body, lycopene must be incorporated into lipoprotein molecules. This process takes place in hepatocytes and intestinal epithelial cells and can be severely impaired with age, metabolic syndrome, and atherosclerosis (Borel et al, 2015;Diwadkar-Navsariwala et al, 2003;Petyaev, 2016;Roohbakhsh et al, 2017). Patients were screened, enrolled, and randomized into two major groups of the study.…”

Section: Discussionmentioning

confidence: 99%

“…The 13 linearly aligned double bonds in the lycopene molecule make it the most powerful antiradical compound in the carotenoid family and epitomize its biological function (Igielska‐Kalwat, Gościańska, & Nowak, ). There is a growing body of scientific evidence that the antioxidant properties of lycopene confer resistance to cardiovascular disease, cancer, diabetes, and inflammatory diseases (Bahonar, Saadatnia, Khorvash, Maracy, & Khosravi, ; Gajowik & Dobrzyńska, ; Petyaev, ; Roohbakhsh, Karimi, & Iranshahi, ). Lycopene is classed as a nonessential nutrient and therefore, there is no recommended daily intake.…”

Section: Introductionmentioning

confidence: 99%

“…There is a growing body of scientific evidence that the antioxidant properties of lycopene confer resistance to cardiovascular disease, cancer, diabetes, and inflammatory diseases (Bahonar, Saadatnia, Khorvash, Maracy, & Khosravi, 2017;Gajowik & Dobrzyńska, 2014;Petyaev, 2016;Roohbakhsh, Karimi, & Iranshahi, 2017). Lycopene is classed as a nonessential nutrient and therefore, there is no recommended daily intake.…”

Section: Introductionmentioning

confidence: 99%

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Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Petyaev

Dovgalevsky

Klochkov

et al. 2018

Food Science & Nutrition

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Oxidative stress and antioxidant deficiency play a pivotal role in initiation, development, and outcomes of cardiovascular disease. Pharmacokinetic parameters as well as the impact of highly bioavailable lycopene on cardiovascular variables, markers of inflammation and oxidation were investigated during a 30‐day clinical trial in patients with coronary vascular disease. The patients were randomized into two major groups and were supplemented with a single 7 mg daily dose of lycopene ingested either in the form of lactolycopene (68 patients) or in the form of lycosome‐formulated GA lycopene (74 patients). The endpoints included cardiovascular function parameters, serum lipids, and four markers of oxidative stress and inflammation. Ingestion of lycosome‐formulated lycopene increased serum lycopene levels by 2.9‐ and 4.3‐fold, respectively, after 2 and 4 weeks of the trial, whereas supplementation with lactolycopene upregulated serum lycopene by half‐fold only after 4 weeks of ingestion. Lycosome formulation of lycopene resulted by the end of the trial in a threefold reduction in Chlamydia pneumoniae IgG and reduction to the same degree of the inflammatory oxidative damage marker. The decrease in oxidized LDL caused by lycosome‐formulated lycopene was fivefold. Moreover, supplementation with lycosome‐formulated lycopene was accompanied by a significant increase in tissue oxygenation and flow‐mediated dilation by the end of the observational period. In contrast, lactolycopene did not cause any significant changes in the parameters studied. Therefore, enhanced bioavailability of lycopene promotes its antioxidant and anti‐inflammatory functions and endorses a positive effect of lycopene on cardiovascular system.

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Section: Discussionmentioning

confidence: 99%

“…To be transported in the body, lycopene must be incorporated into lipoprotein molecules. This process takes place in hepatocytes and intestinal epithelial cells and can be severely impaired with age, metabolic syndrome, and atherosclerosis (Borel et al, 2015;Diwadkar-Navsariwala et al, 2003;Petyaev, 2016;Roohbakhsh et al, 2017). Patients were screened, enrolled, and randomized into two major groups of the study.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Petyaev

Dovgalevsky

Klochkov

et al. 2018

Food Science & Nutrition

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“…Hyperglycemia and other metabolic syndromes that increase the risk of diabetes stimulate ROS production in mitochondria [ 68 ]. Oxidative stress leads to a chronic inflammatory state coupled with increased ROS production and these events cause cellular dysfunction and apoptosis in the pancreas, liver, endothelium and kidney [ 69 , 70 ]. Under oxidative stress conditions of hyperglycemia or insulin resistance, the mitochondrial ultrastructure is disturbed and its respiration is impaired [ 71 , 72 ].…”

Section: Effect Of Astaxanthin On Diseases Associated With Oxidatimentioning

confidence: 99%

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

2018

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Oxidative stress is a major contributor to the pathogenesis of various human diseases as well as to the aging process. Mitochondria, as the center of cellular metabolism and major regulators of redox balance, play a critical role in disease development and progression. Mitochondrial dysfunction involving structural and metabolic impairment is prominent in oxidative stress-related diseases. Increased oxidative stress can damage mitochondria, and subsequent mitochondrial dysfunction generates excesses of mitochondrial reactive oxygen species that cause cellular damage. Mitochondrial dysfunction also activates the mitochondrial apoptotic pathway, resulting in cellular death. Astaxanthin, a red-colored xanthophyll carotenoid, exerts an anti-oxidative and anti-inflammatory effect on various cell lines. In this manner astaxanthin maintains mitochondrial integrity under various pathological conditions. In this review, the inhibitory effects of astaxanthin on oxidative stress-induced mitochondrial dysfunction and related disease development are discussed.

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Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders

Yaqoob

Arshad

Imran

et al. 2021

Food Science & Nutrition

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Metabolic syndrome are a cluster of metabolic disorders in the same individual. The primary agreement concerning the description of the metabolic syndrome was established by the International Diabetes Federation (IDF) in the year of 2005. According to IDF, the main risk factor is obesity which is calculated based on body mass index (BMI) and waist circumference. The additional factors for the diagnosis of metabolic syndrome are reduced high-density lipoprotein (HDL) cholesterol, fasting plasma glucose, triglycerides, or blood pressure-. The patho physiology of metabolic syndrome is very composite and is not clearly established. The prevalence of metabolic syndrome is high among those individuals who are older, obese, having insulin resistance, and living a sedentary life style. The main risk factors are excess caloric intake, genetics, weight, lifestyle, and aging (Bonomini et al., 2015).Metabolic syndrome and the risk factors associated with this syndrome such as atherosclerosis, hypertension, dyslipidemia, and hyperglycemia are the main reasons for increasing medical issues in industrialized countries. The main risk factors for rising metabolic syndrome are physical immobility and a diet high in carbohydrates and fats (O'Neill & O'Driscoll, 2015). Oxidative stress is the main reason that causes metabolic syndrome (Furukawa et al., 2017).Oxidative stress leads elevationed intracellular stage reactive oxygen species (ROS) that causes damage to DNA, proteins, and lipids.Oxidative stress is associated with numerous pathologies (Schieber

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Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

Cited by 116 publications

References 114 publications

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders

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