Association of the interleukin-10 gene -1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population

Abstract

ABSTRACT.We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms were investigated by polymerase chain reaction-restriction fragment length polymorphism. When compared with the control subjects, patients with ischemic stroke were more likely to be male, have a habit of tobacco smoking, have higher BMI, have hypertension or diabetes mellitus, and have higher levels of TC, LDL-C, HDL-C, and TG. The multivariate logistic regression analyses revealed that the AA genotype of IL10 -1082A/G was significantly associated with development of ischemic stroke in a Chinese population compared with the GG genotype (OR = 1.93, 95%CI = 1.15-3.25). In the dominant model, the association between GA+AA genotype of IL10 -1082A/G and risk of ischemic stroke was also significant compared with the GG genotype, and the adjusted OR (95%CI) for the GA+AA genotype was 1.41 (1.02-1.94). Thus, our study suggests that IL10 gene polymorphisms contribute to the development of ischemic stroke.

Interleukin‐10 negatively modulates extracellular signal‐regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion

“…The relation of lower IL-10 levels with the development of vascular complications has been proposed in some studies. For example, during the stroke, IL-10 levels are below normal [21]. In preeclamptic women, the reduction in Figure 4 The endogenous absence of IL-10 associated with Ang II positively modulates vascular expression of total and phosphorylated ERK 1/2.…”

“…The relation of lower IL‐10 levels with the development of vascular complications has been proposed in some studies. For example, during the stroke, IL‐10 levels are below normal . In preeclamptic women, the reduction in IL‐10 receptors, as well as lower IL‐10 circulating levels, is observed, suggesting IL‐10 as a biomarker of preeclampsia .…”

Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans

“…IL1B took part in 5 pathways, and IL6 took part in 4 pathways which are NOD-like receptor signalling pathways, cytokine-cytokine receptor interactions, TNF-signalling pathway, and Rheumatoid arthritis pathways; CXCL1, CXCL2, and CXCL3 took part in 2-3 pathways including the TNF-signalling pathway, cytokine-cytokine Sex specific signaling analysis of ischemic stroke receptor interactions, and NOD-like receptor signalling pathways. Several studies have shown that immune responses including IL6 [34], IgA [35], CXCL16 [36], TNFSF4 [37], and IL10 [38] were involved in stroke. IL6 and infarction size were reported as independent predictors of short-term stroke outcome in young Egyptian adults [34].…”

Risk of Stroke After Exacerbation of Ischemic Heart Disease: Data of 3‑Years Follow-up

“…Кроме того, много данных накоплено в отношении ассоциации полиморфизма гена IL-10 с атеросклерозом различных локализаций. Ассоциация носительства аллеля А полиморфного маркера A(-1082)G с развитием инсульта неоднократно выявлена в различных азиатских популяциях [15][16][17]. В исследовании PROSPER (Pravastatin in the Elderly at Risk) показана ассоциация риска развития инсульта с носительством генотипа -2849AA полиморфного маркера G (-2849) A гена IL-10 [18].…”

“…Целью исследования был анализ возможной ассоциации клинических и генетических факторов с развитием инсульта у больных, перенесших обострение ИБС. (7): [14][15][16][17][18][19][20][21][22].…”