Association of SDF-1 with Metastasis in Breast Cancer Patient at Sanglah Hospital, Bali

Abstract

Background: More than 24% breast cancer patients came to Sanglah Teaching Hospital with distant metastasis which cause 90% of cancer related death. Distant metastasis is complex process of interaction between tumor cells and its micro environment involving chemoattractant cytokines which lead circulating tumor cells toward target organs. One of the most common cytokines involved in metastasis of multiple tumor is SDF-1, produces by target organ or tumor cells it selves. However, only few studies ever evaluate the relationship between its concentrations in tumor tissue with metastasis. Method: A cross sectional analysis study was conducted involving clinical data and paraffin blocks from 46 patients. Samples were grouped into metastasis and non-metastasis group and level of tumor tissue SDF-1 was evaluated by immunohistochemistry method.

Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer

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Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients

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“…Patients' Satisfaction After Breast Reconstruction Surgery Using Autologous versus Implants: A Meta-Analysis 3,4]. Breast reconstruction techniques have evolved significantly over the years, providing a variety of options for restoring the appearance of the breasts and improving patient outcomes.…”

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