Association of Renal Function and Direct-Acting Antiviral Agents for HCV: A Network Meta-Analysis

Kao, Chih-Chin; Lin, Yu-Shiuan; Chu, Heng-Cheng; Fang, Te-Chao; Wu, Mai‐Szu; Kang, Yi No

doi:10.3390/jcm7100314

Cited by 15 publications

(9 citation statements)

References 45 publications

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“…The primary design was registered on PROSPERO (CRD42018118063). The research team involved a neurologist, an anesthesiologist, and an experienced researcher in systematic review and meta-analysis [75,76,77]. The neurologist and anesthesiologist also have experience on conducting systematic reviews and meta-analyses [78,79].…”

Section: Methodsmentioning

confidence: 99%

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Huang

Lin

et al. 2019

IJMS

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We aimed to evaluate the response rate of migraines by using anti-calcitonin gene-related peptide (anti-CGRP) for patients with migraines. We searched three main medical databases up to 29 March 2019. No restriction on language and publication time were applied. Eligible trials included randomized clinical trials investigating a 50%, 75%, and 100% response rate of migraine patients after anti-CGRP intervention. The collected data were dichotomous, and risk ratios (RRs) with a 95% confidence interval (CI) were used to present the quantitative synthesis results. The systematic review identified 16 eligible randomized clinical trials (RCTs) with 9439 patients. Eight of the 16 trials with 2516 patients reported a 50% response rate, and the pooled results showed a significant benefit from anti-CGRP. However, the effects seem to gradually reduce from the first month (RR 1.99, 95% CI 1.59 to 2.49) to the third month (RR 1.48, 95% CI 1.26 to 1.75) of treatment. The magnitude of effect was influenced by the type of anti-CGRP, according to the test for differences between subgroups (I-square = 53%). The funnel plots and Egger’s tests did not show serious small study effects in the results. In conclusion, the current evidences confirmed that anti-CGRP treatment can reduce migraine pain in the short term (within three months), but the long-term effect should be investigated in the future. Moreover, its effects may be influenced by the type and dose of anti-CGRP. Therefore, future studies should make direct comparisons among anti-CGRP medications.

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Section: Methodsmentioning

confidence: 99%

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Huang

Lin

et al. 2019

IJMS

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“…10 Research conducted by Chin-chin Kao et al, reported that the group without renal impairment and early CKD (GFR ≥ 60 ml/min/1,73 m 2 ) had a lower risk of kidney dysfunction compared to the advanced CKD group (GFR < 60 ml/min/1,73 m 2 ) after DAA administration. 11 And a study from Taiwan by Hsu et al, stated that in HCV-infected patients who was successfully treated, there was an improvement in GFR, thereby reducing the risk of end-stage renal disease by 84 %. 12…”

Section: Discussionmentioning

confidence: 99%

Association Between Glomerular Filtration Rate and Direct-Acting Antiviral Regiment in Chronic Hepatitis C: A Retrospective Cohort Study

Lindriawaty¹,

Daud²,

Kasim³

et al. 2020

Int Res J Pharm

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Treatment of hepatitis C virus (HCV) infection is currently developing, but some antiviral agents are reported to cause kidney dysfunction. Currently, direct-acting antivirals (DAA) are the best choice in the management of HCV infection with high efficacy, minimal side effects and better tolerability. This study was conducted to evaluate the glomerular filtration rate (GFR) given DAA regiment outcome in hepatitis C patients. An observational analytic study, with a prospective cohort design, was conducted at Wahidin Sudirohusodo Hospital. Subjects included were patients diagnosed with HCV infection and treated with DAA. Patients with hepatitis B or human immunodeficiency virus co-infection or have chronic kidney disease were excluded. Serum creatinine was evaluated before and after observational period; 12 weeks in non-cirrhosis and 24 weeks in cirrhosis patients. Independent t-test, Paired t-test, and Chi-square were used for statistical analysis of the data. A total of 50 subjects were evaluated, 25 subjects (50 %) included to the sofosbuvir-simeprevir regiment group, 22 subjects (44 %) in sofosbuvir-daclatasvir regiment group and 3 subjects (6 %) in sofosbuvirribavirin regiment group. There is no association between 12 weeks or 24 weeks of treatment period with GFR in pre-and post-DAA treatment (p-value > 0.05). There is no association between the type of DAA combination regiment with GFR in pre-and post-DAA treatment (p-value > 0.05). There is no association between DAA characteristic based on the duration of treatment and regiment of DAA with glomerular filtration rate in chronic hepatitis C patients.

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“…Our team members are medical doctors in a department of ophthalmology and an experienced researcher in systematic reviews with meta-analysis. [20][21][22][23] We completed the evidence selection, quality assessment, and quantitative synthesis according to the PRISMA guidelines. 24 The study protocol was registered on PROSPERO (CRD42019117429): https://www.crd.york.ac.uk/ PROSPERO/display_record.php?RecordID=117429.…”

Section: Methodsmentioning

confidence: 99%

<p>An Updated Systematic Review With Meta-Analysis Of Randomized Trials On Topical Cyclosporin A For Dry-Eye Disease</p>

Tuan¹,

Chi²,

Kang³

2020

DDDT

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Background/Aims: To evaluate the effects of topical cyclosporin A (CsA) and artificial tears (ATs) for treating patients with dry-eye disease (DED). Methods: On January 25, 2019, five electronic databases and reference lists were searched for randomized clinical trials (RCTs) comparing CsA with ATs among patients with DED. The search strategy had no restriction on language or time. Two authors extracted surgery, mean age, anesthesia for Schirmer's test, tear-breakup time, Schirmer's test score, fluorescein-staining score, ocular surface-disease index, and adverse events. Mean differences (MDs) were calculated for continuous outcomes and Peto ORs for dichotomous data with zero cells. Results were analyzed with 95% CIs in a random-effect model. Results: Eleven RCTs recruiting 1,085 cases with DED were included. Pooled results showed that CsA had better tear-breakup time (MD 0.94, 95% CI 0.08-1.80), fluoresceinstaining score (standardized MD −0.72, 95% CI −1.28 to −0.16), and ocular surface-disease index (MD −4.75, 95% CI −6.31 to −3.18) when compared to ATs. Although CsA had more adverse events than ATs (Peto OR 7.70, 95% CI 3.17-18.68), no serious adverse events were reported. Conclusion: Overall, CsA is an effective option for treating patients with DED, yet our evidence indicated decreasing effects when CsA was combined with ATs. CsA may be worth suggesting to relatively older patients with DED. We anticipate further RCTs to explore the effects of treatment duration, optimal dosage, and efficacy of CsA in different DED etiology.

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Association of Renal Function and Direct-Acting Antiviral Agents for HCV: A Network Meta-Analysis

Cited by 15 publications

References 45 publications

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials

Association Between Glomerular Filtration Rate and Direct-Acting Antiviral Regiment in Chronic Hepatitis C: A Retrospective Cohort Study

<p>An Updated Systematic Review With Meta-Analysis Of Randomized Trials On Topical Cyclosporin A For Dry-Eye Disease</p>

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