Association Between Glomerular Filtration Rate and Direct-Acting Antiviral Regiment in Chronic Hepatitis C: A Retrospective Cohort Study

Abstract

Treatment of hepatitis C virus (HCV) infection is currently developing, but some antiviral agents are reported to cause kidney dysfunction. Currently, direct-acting antivirals (DAA) are the best choice in the management of HCV infection with high efficacy, minimal side effects and better tolerability. This study was conducted to evaluate the glomerular filtration rate (GFR) given DAA regiment outcome in hepatitis C patients. An observational analytic study, with a prospective cohort design, was conducted at Wahidin Sudirohusodo Hospital. Subjects included were patients diagnosed with HCV infection and treated with DAA. Patients with hepatitis B or human immunodeficiency virus co-infection or have chronic kidney disease were excluded. Serum creatinine was evaluated before and after observational period; 12 weeks in non-cirrhosis and 24 weeks in cirrhosis patients. Independent t-test, Paired t-test, and Chi-square were used for statistical analysis of the data. A total of 50 subjects were evaluated, 25 subjects (50 %) included to the sofosbuvir-simeprevir regiment group, 22 subjects (44 %) in sofosbuvir-daclatasvir regiment group and 3 subjects (6 %) in sofosbuvirribavirin regiment group. There is no association between 12 weeks or 24 weeks of treatment period with GFR in pre-and post-DAA treatment (p-value > 0.05). There is no association between the type of DAA combination regiment with GFR in pre-and post-DAA treatment (p-value > 0.05). There is no association between DAA characteristic based on the duration of treatment and regiment of DAA with glomerular filtration rate in chronic hepatitis C patients.