Treatment of hepatitis C virus (HCV) infection is currently developing, but some antiviral agents are reported to cause kidney dysfunction. Currently, direct-acting antivirals (DAA) are the best choice in the management of HCV infection with high efficacy, minimal side effects and better tolerability. This study was conducted to evaluate the glomerular filtration rate (GFR) given DAA regiment outcome in hepatitis C patients. An observational analytic study, with a prospective cohort design, was conducted at Wahidin Sudirohusodo Hospital. Subjects included were patients diagnosed with HCV infection and treated with DAA. Patients with hepatitis B or human immunodeficiency virus co-infection or have chronic kidney disease were excluded. Serum creatinine was evaluated before and after observational period; 12 weeks in non-cirrhosis and 24 weeks in cirrhosis patients. Independent t-test, Paired t-test, and Chi-square were used for statistical analysis of the data. A total of 50 subjects were evaluated, 25 subjects (50 %) included to the sofosbuvir-simeprevir regiment group, 22 subjects (44 %) in sofosbuvir-daclatasvir regiment group and 3 subjects (6 %) in sofosbuvirribavirin regiment group. There is no association between 12 weeks or 24 weeks of treatment period with GFR in pre-and post-DAA treatment (p-value > 0.05). There is no association between the type of DAA combination regiment with GFR in pre-and post-DAA treatment (p-value > 0.05). There is no association between DAA characteristic based on the duration of treatment and regiment of DAA with glomerular filtration rate in chronic hepatitis C patients.
14597 Background: Mafraq Hospital is the largest tertiary hospital in United Arab Emirates (UAE). The exact charecterstics of colon cancer in this country are not yet documented. Methods: This is a retrospective study of colo-rectal cancer. Files of all patients with the diagnosis of colo-rectal cancer between 1/99 and 12/05 at the department of Oncology at Mafraq Hospital were reviewed. Intent to treat analysis was used. Total of 176 patients were seen. The youngest was age 18 and the oldest was 79 Results: Mean age of patients at initial presentation was 48.5. Gender was as follows: males 121 patients (68.7%) and females 55 patients (31.3%). Mean male age at initial presentation was 49.5, and mean female age was 46.4. UAE Citizens represented 34 patients (19.3%) of cohort and non-citizens 137 patients (80.7%). Cancer stages were as follows: stage I: 7 patients (4.7%), stage II: 41 patients (27.5%), stage III: 48 patients (32.2%), stage IV: 53 patients (35.6%). 27 patient elected to do staging work-up and further care elsewhere. Conclusions: 1- Colon cancer screening is needed in order to diagnose cancer at earlier stages. 2- As our patients are younger than patients in the West. Colon cancer screening should be done at an earlier age. No significant financial relationships to disclose.
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