Association of prenatal exposure to fine particulate matter pollution with childhood eczema

Yao, Tsung Chieh; Huang, Hsin Yi; Pan, Wen Chi; Wu, Caiyan; Tsai, Shun Yu; Hung, Chi Yen; Lü, Kun; Chang-Chien, Ju; Tseng, Chih; Wu, Chih Da; Chen, Yu Chen; Huang, Yvonne J.; Tsai, Hui Ju

doi:10.1111/all.14738

Cited by 19 publications

(9 citation statements)

References 13 publications

(20 reference statements)

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“…PM 2.5 exposure during gestation weeks 7-17 was associated with increased childhood eczema. 3 This result is consistent with ours regarding the association between increased AD at 1 year of age and PM 2.5 exposure during the first trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 93%

“…1,2 Among several environmental factors, particulate matter with an aerodynamic diameter of less than 2.5 μm (PM 2.5 ) and maternal distress during pregnancy are associated with AD. [3][4][5][6][7] PM 2.5 is a mixture of tiny solid and liquid particles suspended in the air. PM 2.5 is considered especially harmful to human health because they can enter deeper into our bodies.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Kim

Yang

Lim

et al. 2021

Clinical & Translational All

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Background:The prevalence of atopic dermatitis (AD) is increasing worldwide.Prenatal particulate matter with an aerodynamic diameter <2.5 μm (PM 2.5 ) and maternal anxiety during pregnancy has been suggested as a potential causes of AD. This study investigated the effects of prenatal PM 2.5 and maternal anxiety on AD and identified the critical period of PM 2.5 exposure for AD in infants. Methods:This study included 802 children from the COCOA birth cohort study with follow-up data at 1 year of age. PM 2.5 was estimated by land-use regression models and prenatal anxiety was measured with a questionnaire. AD was diagnosed by doctor at 1 year of age. Logistic regression analysis and Bayesian distributed lag interaction models were applied.Sangrok Kim and Song-I Yang contributed equally to this work and considered as co-first authors.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Kim

Yang

Lim

et al. 2021

Clinical & Translational All

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“…The LIGHTS population-based cohort consists of 1513 children who were born in 2010 and 2011 and attended well-child visits and follow-up visits in the Chang Gung Memorial Hospital (CGMH). 20 , 21 , 22 After excluding multiple births ( n = 162) and missing data on asthma or atopy ( n = 8), 1343 children were included in the present study. The flow chart for the enrollment process of study subjects is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Early-life weight gain is associated with non-atopic asthma in childhood

Gau

Lee

et al. 2022

World Allergy Organization Journal

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“…This study included 566 children participating in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) study, a prospective population-based cohort study designed to longitudinally investigate the effects of early-life environmental exposures and genetic predisposition on childhood allergic outcomes. [27][28][29] In the LIGHTS cohort, 1513 children born in 2010-2011 in the Chang Gung Memorial Hospital attended a 6-year follow-up visit.…”

Section: Study Subjectsmentioning

confidence: 99%

Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

Lee

Tsai

Huang

et al. 2022

Pediatric Allergy Immunology

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Background: Few data are available in Asian children regarding the validity of cord blood immunoglobulin E (IgE) in predicting allergic sensitization and pulmonary function. The relationship between cord blood IgE and fraction of exhaled nitric oxide (FeNO) remains unknown. This study investigated the associations of cord blood IgE with allergic sensitization, FeNO, pulmonary function, and allergic diseases in Asian children. Methods: Five hundred and sixty-six Asian children with valid cord blood IgE measurements at birth participated a 6-year follow-up visit including a questionnaire, serum total and allergen-specific IgE, FeNO measurement, and spirometry. Regressionbased analyses with covariates adjustment were applied. Results: Cord blood IgE levels were significantly associated with FeNO levels (β = 0.131, p < .001) and serum total IgE levels (β = 0.325, p < .001). Cord blood IgE levels were positively associated with allergic sensitization (adjusted odds ratio [AOR] = 2.22, p < .001), and sensitization to mites (p = .002), animals (p = .023), and foods (p = .048).Subjects with cord blood IgE ≥0.24 kU/L (the optimal cutoff) were significantly associated with an increased risk of allergic sensitization (AOR = 2.63, p < .001) and asthma (AOR = 2.35, p = .024) than those with cord blood IgE <0.24 kU/L. Subjects with cord blood IgE ≥0.24 kU/L had significantly higher FeNO levels than those with cord blood IgE <0.24 kU/L (p = .028). There were no significant associations between cord blood IgE levels and pulmonary function parameters.This study was approved by the Institutional Review Board of Chang Gung Medical Foundation (No.201600334A3), and the parents of each subject provided written informed consent. | Cord blood IgECord blood was collected by needle puncture from the umbilical cord vein at birth, and separated serum was frozen before analyses. The Conclusion: Cord blood IgE ≥0.24 kU/L predicts allergic sensitization, FeNO elevation, and asthma among Asian schoolchildren, suggesting cord blood IgE would be useful for identifying newborns at risk of subsequent allergic sensitization and allergic airway inflammation.

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Association of prenatal exposure to fine particulate matter pollution with childhood eczema

Cited by 19 publications

References 13 publications

Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Early-life weight gain is associated with non-atopic asthma in childhood

Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

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Association of prenatal exposure to fine particulate matter pollution with childhood eczema

Cited by 19 publications

References 13 publications

Prenatal PM2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Prenatal PM2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Early-life weight gain is associated with non-atopic asthma in childhood

Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

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Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study