Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

Abstract

Background: Few data are available in Asian children regarding the validity of cord blood immunoglobulin E (IgE) in predicting allergic sensitization and pulmonary function. The relationship between cord blood IgE and fraction of exhaled nitric oxide (FeNO) remains unknown. This study investigated the associations of cord blood IgE with allergic sensitization, FeNO, pulmonary function, and allergic diseases in Asian children. Methods: Five hundred and sixty-six Asian children with valid cord blood IgE measurements at birth participated a 6-year follow-up visit including a questionnaire, serum total and allergen-specific IgE, FeNO measurement, and spirometry. Regressionbased analyses with covariates adjustment were applied. Results: Cord blood IgE levels were significantly associated with FeNO levels (β = 0.131, p < .001) and serum total IgE levels (β = 0.325, p < .001). Cord blood IgE levels were positively associated with allergic sensitization (adjusted odds ratio [AOR] = 2.22, p < .001), and sensitization to mites (p = .002), animals (p = .023), and foods (p = .048).Subjects with cord blood IgE ≥0.24 kU/L (the optimal cutoff) were significantly associated with an increased risk of allergic sensitization (AOR = 2.63, p < .001) and asthma (AOR = 2.35, p = .024) than those with cord blood IgE <0.24 kU/L. Subjects with cord blood IgE ≥0.24 kU/L had significantly higher FeNO levels than those with cord blood IgE <0.24 kU/L (p = .028). There were no significant associations between cord blood IgE levels and pulmonary function parameters.This study was approved by the Institutional Review Board of Chang Gung Medical Foundation (No.201600334A3), and the parents of each subject provided written informed consent. | Cord blood IgECord blood was collected by needle puncture from the umbilical cord vein at birth, and separated serum was frozen before analyses. The Conclusion: Cord blood IgE ≥0.24 kU/L predicts allergic sensitization, FeNO elevation, and asthma among Asian schoolchildren, suggesting cord blood IgE would be useful for identifying newborns at risk of subsequent allergic sensitization and allergic airway inflammation.

Pulmonary function in school-age children following intravitreal injection of bevacizumab for retinopathy of prematurity

“…This retrospective case–control study was conducted between 2016/07/01 and 2020/07/31 at Chang Gung Memorial Hospital, Taoyuan, Taiwan. Three groups of subjects were enrolled in this study: Group 1 consisted of full-term children without ROP, matched to groups 2 and 3 by age at pulmonary function testing, who underwent baseline pulmonary function testing in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort 24 – 28 . Group 2 consisted of preterm children with no history of intravitreal bevacizumab (IVB) treatment, and this group was composed of three parts: patients without ROP, patients with untreated ROP, and patients who received laser treatment.…”

Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity

“…This study used the data collected from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort, including 1513 children who were born in 2010 through 2011 in Chang Gung Memorial Hospital and who attended a follow-up visit at a mean age of 6.4 years, ranging from 5.5 to 7.9 years, as has been described elsewhere [21][22][23][24][25][26][27]. BMI and body fat percentages were measured during the follow-up visit between 2016 and 2018.…”

From preschool wheezing to asthma: Determinants

“…For instance, in a cohort of Asian children, elevated cord blood immunoglobulin E levels were associated with future allergic sensitization and asthma development. 9 Thus, interventions need to be appropriately timed to be effective.…”

“…This is also consistent with prior studies suggesting the importance of immune tolerance at critical developmental stages in preventing asthma. For instance, in a cohort of Asian children, elevated cord blood immunoglobulin E levels were associated with future allergic sensitization and asthma development 9 . Thus, interventions need to be appropriately timed to be effective.…”