Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Abstract

Background:The prevalence of atopic dermatitis (AD) is increasing worldwide.Prenatal particulate matter with an aerodynamic diameter <2.5 μm (PM 2.5 ) and maternal anxiety during pregnancy has been suggested as a potential causes of AD. This study investigated the effects of prenatal PM 2.5 and maternal anxiety on AD and identified the critical period of PM 2.5 exposure for AD in infants. Methods:This study included 802 children from the COCOA birth cohort study with follow-up data at 1 year of age. PM 2.5 was estimated by land-use regression models and prenatal anxiety was measured with a questionnaire. AD was diagnosed by doctor at 1 year of age. Logistic regression analysis and Bayesian distributed lag interaction models were applied.Sangrok Kim and Song-I Yang contributed equally to this work and considered as co-first authors.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

“…As shown in Supplementary Figure S1, the selection process was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram, with non-duplicated studies retrieved from the online database. After screening the title, abstract, and full-text gradually, 18 studies were excluded for reasons, such as no eczema data, cross-sectional design, 8,16,17 overlapped population, 18 and adult AD, 19 leaving 22 studies in the final analysis.…”

Preventative Effects of Antioxidants against PM10 on Serum IgE Concentration, Mast Cell Counts, Inflammatory Cytokines, and Keratinocyte Differentiation Markers in DNCB-Induced Atopic Dermatitis Mouse Model

“…Wang et al reported that PM 2.5 promotes the IgE-mediated mast cell activation of ROS [ 40 ]. Several groups [ 41 , 42 , 43 ] reported that air pollution, including PM 10 , is associated with an increased risk of atopic dermatitis. The study showed that cytotoxic effects and PM concentrations were not always correlated.…”