Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Abstract

A b s t r a c tBackground: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Aim:The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM).Methods: A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed.Results: There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20-0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60-0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. Conclusions:The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.

Prognostic Value of Mean Platelet Volume (MPV) to Predict Perfusion Defects in Myocardial SPECT in Diabetic and Non-Diabetic Patients

“…They claimed that patients with non-viable myocardium had signi cantly higher levels of MPV. They recommended to consider MPV as a cheap, practical and easily measurable index which could be used in the prognosis of ischemic cardiomyopathy [41].…”

“…Discriminative aspects of our study compared to similar investigations [21][22][23] are as follows; rst, we extensively assessed different systolic and diastolic indices to nd even subtle evidence of CAD in patients with DM, second, we used both the Cedars-Sinai tools Quantitative Perfusion SPECT (QPS) and the Quantitative gated SPECT (QGS) as well as corridor 4DM software (University of Michigan/ Mirada Medical) for better interpretation of scans.…”

A Retrospective Analysis of Haemotologic Parameters in Patients with Bilateral Tinnitus

“…As a blood marker MPV shows platelet volume and gives information about platelet function. Highly MPV values were associated with more platelet aggregation and increased risk of ischemic injury (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)21). There are many studies on MPV and tinnitus relationship.…”

Utilization of Mean Platelet Volume (MPV) to Predict Perfusion Defects in Myocardial SPECT in Diabetic and Non-Diabetic Patients

“…Therefore, the aim of this study was to assess the use of myocardial perfusion scans to study the association between MPV and myocardial ischemic severity in patients with DM and healthy individuals. Discriminative aspects of our study compared to similar investigations [21][22][23] are as follows; rst, we extensively assessed different systolic and diastolic indices to nd even subtle evidence of CAD in patients with DM, second, we used both the Cedars-Sinai tools Quantitative Perfusion SPECT (QPS) and the Quantitative gated SPECT (QGS) as well as corridor 4DM software (University of Michigan/ Mirada Medical) for better interpretation of scans.…”