A Retrospective Analysis of Haemotologic Parameters in Patients with Bilateral Tinnitus

Düzenli, Ufuk; Bozan, Nazım; Aslan, Mehmet; Özkan, H. Turhan; Turan, Mahfuz; Kıroğlu, Ahmet Faruk

doi:10.5505/ejm.2018.02703

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…For the inflammatory markers IL-6, CRP, and NLR, no associations were found with psychological or audiological tinnitus-related variables. Previous studies have observed increased NLR in tinnitus patients ( Ozbay et al, 2015 ; Yildiz et al, 2020 ; Demir, 2021 ), but conflicting findings exist as well ( Bayram et al, 2016 ; Düzenli et al, 2018 ). While we observed correlations of IL-1b, TNF-α, and IGF-1 with tinnitus loudness, these associations did not persist in network analysis.…”

Section: Discussionmentioning

confidence: 95%

Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

et al. 2022

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BackgroundDepression and anxiety are known to be associated with stress-induced changes in the immune system. Bothersome tinnitus can be related to stress and often co-occurs with depression and anxiety. This study investigates associations of psychological and audiological tinnitus-related factors with inflammatory parameters and immune cell subsets in chronic tinnitus patients as well as treatment-related effects.MethodsThis longitudinal study of inpatients treated with compact multimodal tinnitus-specific cognitive behavioral therapy included four repeated measurement sessions: baseline (N = 41), treatment end, 7.8-week (N = 35), and 13.8-week follow-up (N = 34). Data collection included audiometric testing, blood sampling, and psychometric questionnaires: Tinnitus Handicap Inventory (THI), Perceived Stress Questionnaire (PSQ-20), and Hospital Anxiety Depression Scale (HADS). Flow cytometry was used to analyze immune cell subsets. Statistical analyses comprised correlation and network analysis (cross-sectional), and linear mixed effect models (longitudinal).ResultsBootstrapped network analysis showed negative averaged cross-sectional associations of cytotoxic natural killer (NKc) cell frequency (CD56 + CD16+) and PSQ-20 (−0.21 [−0.48, 0]) and of regulatory natural killer (NKreg) cell frequency (CD56 + CD16dim/−) and HADS anxiety (−0.14 [−0.38, 0]). No significant treatment effects were found. A negative predictive effect of baseline PSQ-20 scores (β = −6.22 [−12.18, −0.26], p = 0.041) and a positive predictive effect of baseline ferritin levels (β = 8.90 [2.76, 15.03], p = 0.004) on NKc cell frequency across the repeated measurement sessions were observed.ConclusionWe observed negative relationships between perceived stress levels and NKc cell frequency and between anxiety levels and NKreg cell frequency in chronic tinnitus patients. These exploratory results suggest stress−/anxiety-related immune alterations in bothersome tinnitus but need to be tested in further confirmatory studies with larger sample sizes. The potential of NK cells as biomarkers of emotional distress in chronic tinnitus should be further investigated.

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Section: Discussionmentioning

confidence: 95%

Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

et al. 2022

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“…Therefore, platelets are an important source of cytokines in the inflammatory response. On the other hand, increased platelet volumes may be an indicator of a prothrombic condition or even cause thrombosis, e.g., in the internal auditory artery leading to hypoperfusion of the cochlea, impairing its function and contributing to the development of tinnitus [28,38,42]. Finally, platelets are involved in glutamate uptake.…”

Section: Platelet Involvement In Tinnitusmentioning

confidence: 99%

The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis

Mennink

Aalbers

Dijk

et al. 2022

JCM

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Subjective tinnitus is the perception of sound without the presence of an external source. Increasing evidence suggests that tinnitus is associated with inflammation. In this systematic review, the role of inflammation in subjective tinnitus was studied. Nine animal and twenty human studies reporting inflammatory markers in both humans and animals with tinnitus were included. It was established that TNF-α and IL-1β are increased in tinnitus, and that microglia and astrocytes are activated as well. Moreover, platelet activation may also play a role in tinnitus. In addition, we elaborate on mechanisms of inflammation in tinnitus, and discuss potential treatment options targeting inflammatory pathways.

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“…PLR, an inflammatory marker used with NLR, was also reported to be higher in tinnitus patients with high-frequency hearing loss than in those with all frequency hearing loss [ 35 ]. However, some studies reported that NLR and PLR were not associated with tinnitus, and some even showed opposite results [ 37 , 40 , 49 ]. Significant results were not observed with respect to WBCs but ESR and CRP have shown elevated levels in several studies [ 36 , 37 ].…”

Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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Tinnitus is associated with increased social costs and reduced quality of life through sleep disorders or psychological distress. The pathophysiology of chronic subjective tinnitus, which accounts for most tinnitus, has not been clearly elucidated. This is because chronic subjective tinnitus is difficult to evaluate objectively, and there are no objective markers that represent the diagnosis or therapeutic effect of tinnitus. Based on the results of studies on patients with chronic subjective tinnitus, objective and measurable biomarkers that help to identify the pathophysiology of tinnitus have been summarized. A total of 271 studies in PubMed, 303 in EMBASE, and 45 in Cochrane Library were found on biomarkers related to chronic subjective tinnitus published until April 2021. Duplicate articles, articles not written in English, review articles, case reports, and articles that did not match our topic were excluded. A total of 49 studies were included. Three specimens, including blood, saliva, and urine, and a total of 58 biomarkers were used as indicators for diagnosis, evaluation, prognosis, and therapeutic effectiveness of tinnitus. Biomarkers were classified into eight categories comprising metabolic, hemostatic, inflammatory, endocrine, immunological, neurologic, and oxidative parameters. Biomarkers can help in the diagnosis, measure the severity, predict prognosis, and treatment outcome of tinnitus.

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A Retrospective Analysis of Haemotologic Parameters in Patients with Bilateral Tinnitus

Cited by 8 publications

References 23 publications

Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

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