Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

Basso, Laura; Boecking, Benjamin; Neff, Patrick; Brüeggemann, Petra; El‐Ahmad, Linda; Brasanac, Jelena; Rose, Matthias; Gold, Stefan M.; Mazurek, Birgit

doi:10.3389/fpsyg.2022.871822

Cited by 2 publications

(2 citation statements)

References 69 publications

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“…Our findings suggesting a relationship between psychosocial stress and NK cell dysfunction are consistent with prior studies associating psychosocial factors, including chronic stress, anxiety 62 , and depression 63 , with NK cell function. For example, stress and anxiety were associated with reduced CD56 + /CD16 + NK cells in a cohort of patients with chronic tinnitus.…”

Section: Discussionsupporting

confidence: 92%

“…For example, stress and anxiety were associated with reduced CD56 + /CD16 + NK cells in a cohort of patients with chronic tinnitus. 62 NK cytotoxicity, degranulation, and IFN-γ secretion were also reduced in individuals who had experienced maternal deprivation as a form of early life adversity. 64 Maternal deprivation was associated with increased serum glucose levels, a marker of cardiometabolic dysfunction and a risk factor for CVD.…”

Section: Discussionmentioning

confidence: 97%

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Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Baumer,

Singh,

Baez

et al. 2023

Preprint

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SummaryAdverse social determinants of health (aSDoH) are associated with obesity and related comorbidities like diabetes, cardiovascular disease, and cancer. Obesity is also associated with natural killer cell (NK) dysregulation, suggesting a potential mechanistic link. Therefore, we measured NK phenotypes and function in a cohort of African-American (AA) women from resource-limited neighborhoods. Obesity was associated with reduced NK cytotoxicity and a shift towards a regulatory phenotype.In vitro, LDL promoted NK dysfunction, implicating hyperlipidemia as a mediator of obesity-related immune dysregulation. Dual specific phosphatase 1 (DUSP1) was induced by LDL and was upregulated in NK cells from subjects with obesity, implicating DUSP1 in obesity-mediated NK dysfunction.In vitro, DUSP1 repressed LAMP1/CD107a, depleting NK cells of functional lysosomes to prevent degranulation and cytokine secretion. Together, these data provide novel mechanistic links between aSDoH, obesity, and immune dysregulation that could be leveraged to improve outcomes in marginalized populations.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Baumer,

Singh,

Baez

et al. 2023

Preprint

View full text Add to dashboard Cite

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Investigating the Link Between Anxiety and Multiple Sclerosis: A Review

Mohammed

2023

Preprint

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Background Nearly one billion people worldwide have a mental disorder. During the last few years, the number of people suffering from psychological disorders such as depression and anxiety has increased by more than 25%. Just over 22% of multiple sclerosis (MS) patients experience anxiety. MS is an autoimmune disorder of the central nervous system (CNS) that is characterized by a complex interplay of factors, leading to inflammation, demyelination, and neurodegeneration. The disease strikes more people every year with no definitive aetiology. Many genetic, infectious, and environmental factors were confirmed as MS risk factors, but no psychological factors have been considered. Objective This review aims to explore the effect of anxiety on the manifestation of MS, the correlation between anxiety and MS symptomology, and possible connection points between anxiety and MS. Method A literature search was conducted in the NCBI PubMed database to investigate the impact of anxiety on MS symptomology and episodes, as well as any possible link between anxiety and MS. The search was conducted up to October 2022. Results Database searches retrieved a total of 1,607 articles for the phrase ‘multiple sclerosis and anxiety’ published from 1964 to 2022. Data were thoroughly reviewed to include only statistically significant associations. Several articles reported strong associations between anxiety and MS symptoms and episodes. Despite the lack of articles exploring the relationship between anxiety and MS, several pointed to the negative effect of anxiety on the immune system. The fact that MS is an autoimmune disorder of the CNS, and that anxiety dysregulates immunity, could indicate that anxiety has an effect on MS. Prospective: Further studies must be undertaken to understand the influence of anxiety on MS; meanwhile, psychological evaluation of MS patients is strongly recommended and needs to be incorporated into treatment plans.

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Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

Cited by 2 publications

References 69 publications

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Investigating the Link Between Anxiety and Multiple Sclerosis: A Review

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