Association of CAPN10 SNP-19 (rs3842570) Polymorphism on Fasting Plasma Glucose, Blood Pressure and Body Mass Index of Javanese Type-2 Diabetes Patients

Tursinawati, Yanuarita; Kartikadewi, Arum; Hakim, Rifqi Fauzan

doi:10.1088/1755-1315/292/1/012031

Cited by 3 publications

(3 citation statements)

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“…Another study showed that both FBG and triglycerides level didn't show a significant difference in each CAPN10 SNP-19 genotype. (22) However, other study noted that subjects with 2R/2R and 2R/3R genotypes had a significantly higher concentration of triglycerides than subjects with 3R/3R genotype. (23) The variation of CAPN10 has the ability to decrease the function of β3 adrenoceptor and adipose cells of obese people.…”

Section: Discussionmentioning

confidence: 92%

CAPN10 SNP-19 is Associated with Susceptibility of Type 2 Diabetes Mellitus: A Javanese Case-control Study

et al. 2020

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BACKGROUND: The health data of Central Java, Indonesia showed that diabetes mellitus (DM) was the second most increasing non-communicable disease in the province. More than 20 genes have been reported to be associated with DM. Calpain-10 (CAPN10) polymorphism has been reported to be associated with Type 2 Diabetes Mellitus (T2DM). However, the association between CAPN10 single nucleotide polymorphism (SNP)-19 and T2DM among Javanese ethnics has never been reported. Therefore, this study was conducted to investigate the association.METHODS: After fasting for 8 hours, blood samples were drawn from veins of 107 T2DM and 107 non diabetic subjects. A half of the drawn blood was collected for identification of CAPN10 SNP-19, and another half for measuring triglycerides and fasting blood glucose (FBG). Identification of CAPN10 SNP-19 was performed with polymerase chain reaction (PCR) method, while measurement of triglycerides and FBG with colorimetric enzymatic method.RESULTS: The number of T2DM Javanese subjects with 2R/3R and 3R/3R CAPN10 SNP-19 genotypes was significantly higher than the number of T2DM Javanese subjects with 2R/2R genotype (p=0.002). When each number of 2R/3R and 3R/3R T2DM subjects was compared with the number of 2R/2R T2DM subjects, the number of 2R/3R T2DM subjects was significantly higher than the number of 2R/2R T2DM subjects (p=0.000).CONCLUSION: Javanese subjects with 2R/3R and 3R/3R CAPN10 SNP19 genotypes might have susceptibility of T2DM.KEYWORDS: Calpain-10, CAPN10, polymorphism, type2 diabetes mellitus, triglycerides, fasting blood glucose

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Section: Discussionmentioning

confidence: 92%

CAPN10 SNP-19 is Associated with Susceptibility of Type 2 Diabetes Mellitus: A Javanese Case-control Study

et al. 2020

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“…Salah satu faktor yang dapat mempengaruhi IMT adalah genetik. Heritabilitas IMT secara genetik diperkirakan antara 24-90% dengan rata-rata sekitar 75% (Erin EH, et al, 2015) Meskipun penelitian yang dilakukan oleh Tursinawati, et al menunjukkan bahwa tidak didapatkan adanya hubungan yang bermakna pada polimorfisme genotip CAPN10 SNP-19 dengan IMT pada pasien T2DM etnis Jawa (Tursinawati, et al, 2019). Perbedaan yang signifikan ditemukan pada nilai ABI antara kelompok DM dan non DM.…”

Section: Pembahasanunclassified

Hubungan Indeks Massa Tubuh (IMT) dengan Ankle Brachial Index (ABI) pada Pasien Diabetes Mellitus Tipe 2 Etnis Jawa

Tursinawati

Kartikadewi

Nuriyah

et al. 2020

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<p>Diabetes mellitus (DM) often give a macrovascular complication such as Peripheral arterial disease (PAD). Ankle-brachial index (ABI) is a sensitive and specific examination for PAD. Obesity can be a risk factor of PAD. Obesity can be classified by the BMI (Body Mass Index) classification. The purpose of this research is to analyze the relationship of BMI with ABI in Type 2 DM (T2DM) patients of Javanese ethnicity. This study was an observational analytic research with case-control design and used a purposive sampling technique. There were 40 case samples and 40 control samples. Data analysis used the Independent T-test and Chi-square test. There was a significant differences on age (p=0,000), METs (p-value=0,003), and ABI (p-value=0,002) between the two groups. In the DM group was found that most abnormal ABIs were found in the higher BMI, even though there was no significant correlation by the statistic (p-value=0,255). BMI contributed less to the ABI value of Javanese ethnic T2DM patients.</p>

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“…[5] The risk factors for DM include: age, gender, genetics, smoking habits and dietary patterns. [6,7] DM could lead to serious issues due to uncontrolled blood glucose levels either in the form of macrovascular or microvascular complications. The macrovascular complications are in the form of heart and brain diseases, as well as stroke and diabetic foot, while the microvascular complications could occur in the kidneys (diabetic nephropathy), eyes (diabetic retinopathy, cataracts) and diabetic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Rural-Urban Differences in Characteristic and Lipid Profile Among Javanese Ethnic of Type 2 Diabetes Patients

Tursinawati¹,

Kartikadewi²,

Yuniastuti³

et al. 2021

Advances in Health Sciences Research

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Background: Urbanization has led to changes in human health with the inception of non-communicable diseases such as Diabetes mellitus (DM). This is generally due to the adaptation to unhealthy and sedentary lifestyles, with poor diet patterns. The purpose of this research is to identify the rural and urban differences in characteristics and lipid profile among the Javanese ethnic of Type 2 Diabetes patients. Method: This was an observational analytic study, with the cross-sectional approach used to obtain data from 102 T2DM patients in Gunungpati (rural), Pandanaran and Purwoyoso Health Centers (urban). The characteristics assessed included age, sex, BMI, blood pressure, blood sugar levels and lipid profile. The BMI was calculated by dividing body weight in kg by body height in meters squared, based on the Asia Pacific criteria. The blood pressure was measured with a mercury sphygmomanometer, then the levels of FPG and lipid profile were taken after the patients fasted for the previous 8 hours. Furthermore, the Mann Whitney U test was used to test the characteristics differences with a significance value of p ≤ 0.05.Results: There were significant differences between FPG control (p = 0.032) and HDL levels (p = 0.006). Meanwhile, characteristic data such as age (p = 0.214), gender (p = 0.790), BMI (p = 0.196), and blood pressure (p = 0.123) did not have significant differences. Furthermore, insignificant results were also obtained at various levels of FPG (p = 0.917), cholesterol (p = 0.436), triglycerides (p = 0.724), LDL (p = 0.188), and Chol / HDL ratio (p = 0.297). In urban areas, the average cholesterol levels (185.59 ± 52.59) , HDL (62.60 ± 16.69 mg / dl), LDL (201.16 ± 59, 36 mg / dl), were higher than those in the rural areas. Conclusion: In the urban group, FPG control was significantly worse than rural. Furthermore, cholesterol, HDL, LDL of Javanese T2DM patients in urban areas are higher than those in rural areas. However, only HDL is significantly different

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Association of CAPN10 SNP-19 (rs3842570) Polymorphism on Fasting Plasma Glucose, Blood Pressure and Body Mass Index of Javanese Type-2 Diabetes Patients

Cited by 3 publications

References 14 publications

CAPN10 SNP-19 is Associated with Susceptibility of Type 2 Diabetes Mellitus: A Javanese Case-control Study

CAPN10 SNP-19 is Associated with Susceptibility of Type 2 Diabetes Mellitus: A Javanese Case-control Study

Hubungan Indeks Massa Tubuh (IMT) dengan Ankle Brachial Index (ABI) pada Pasien Diabetes Mellitus Tipe 2 Etnis Jawa

Rural-Urban Differences in Characteristic and Lipid Profile Among Javanese Ethnic of Type 2 Diabetes Patients

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