Association of anemia and renal function test among diabetes mellitus patients attending Fenote Selam Hospital, West Gojam, Northwest Ethiopia: a cross sectional study

Abate, Alemayehu; Birhan, Wubet; Alemu, Abebe

doi:10.1186/2052-1839-13-6

Cited by 35 publications

(72 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Test of Osmotic fragility Status of RBC is a simple and easy assessment reflecting altered membrane physiology (Prakash, 2013;Priyadarshini et al, 2015;Ebrahim et al, 2012) and is the determinant of stability and strength of RBC in different osmotic gradient (Abate et al, 2013). Hemolysis usually starts at 0.45% -0.05% & it completes at 0.3% -0.33% solution of NaCl.…”

Section: Discussionmentioning

confidence: 99%

Study of Osmotic Fragility Status of Red Blood Cell in Type II Diabetes Mellitus Patients

Rownak

Akhter

Khatun

et al. 2017

European Journal of Environment and Public Health

View full text Add to dashboard Cite

Diabetes Mellitus (DM) is one of the most prevalent non-communicable diseases in the world. Cell membrane injury is an important mechanism for pathophysoilogical changes in DM. Osmotic fragility (OF) status of Red blood cell (RBC) in hyperglycemic patients is expected to be increased. This study was conducted in Chittagong medical college hospital and Chittagong Diabetic Hospital from January 2015 to December 2015. 100 newly diagnosed (duration ≤ 3 years) type II diabetes mellitus patients (Fasting blood glucose is ≥7 mmol/L) were selected as cases. Age, sex and BMI matched 100 healthy subjects were included as control. OF of RBC was measured by traditional method with a series of hypotonic solution of NaCl of different strength in twelve test tubes numbered serially. The relationship of OF with Fasting blood sugar (FBS) and two hours post prandial blood sugar (2 HPPBS) were evaluated. Unpaired Student 't' test and Pearson's correlation coefficient test were done for statistical analysis. p value <0.05 was considered as significant. 87% of cases showed normal hemolysis and only 12% had early hemolysis. Mean value of NaCl solution for partial and complete hemolysis in cases were 0.44±0.06(%) and 0.32±0.02(%) respectively; for control group the findings were 0.04±0.06(%) and 0.32±0.02(%). Significant relationship (p<0.001) was found regarding osmotic fragility with FBS ≥ 7 mmol/L and 2 HPPBS ≥ 11.1 mmol/L. OF of RBC is increased in type II diabetes mellitus.

show abstract

Section: Discussionmentioning

confidence: 99%

Study of Osmotic Fragility Status of Red Blood Cell in Type II Diabetes Mellitus Patients

Rownak

Akhter

Khatun

et al. 2017

European Journal of Environment and Public Health

View full text Add to dashboard Cite

show abstract

“…Despite these facts, anemia is unrecognized in 25% of the diabetic patients [3]. Anemia also develops earlier and is more severe in patients with diabetes than in patients with renal impairment from other causes [4].…”

Section: Introductionmentioning

confidence: 99%

Anemia in Patients with Diabetes Mellitus: Prevalence and Progression

2014

General Med

View full text Add to dashboard Cite

Aim: Anemia is found to contribute to the development and progression of micro and macro-vascular complications of diabetes. This study aimed to determine the prevalence of anemia in patients with diabetes and the occurrence of micro and macro vascular complications in them.Method: This was a retrospective study of 227 Saudi patients with diabetes regularly followed up as outpatients for one year. Patient's demographic profile, history of stroke, ischemic heart disease (IHD), and concomitant hypertension (HT) along with the most recent values of complete blood picture and renal function tests were collected from the database of the health center. Results:The prevalence of anemia in our study population is 55.5%, which is two to three times more common as compared to the result from previous studies. Anemia was six times more common (53.9%) compared to the previous study for the same GFR value (GFR > 60 mL/min/1.73 m 2 ) and half of them in stage one kidney disease. Conclusion:Anemia is a common accompaniment with diabetes and it is seen early even in the absence of renal impairment which necessitate early screening of anemia and further studies to know the possible etiology.

show abstract

“…Several studies suggest that anemia is twice as common in diabetics compared with non-diabetics. Despite these facts, anemia is unrecognized in 25% of patients with diabetes [18,19]. Anemia also develops earlier and is more severe in patients with diabetes than in patients with renal impairment from other causes [20].…”

Section: Discussionmentioning

confidence: 99%

“…Anemia also develops earlier and is more severe in patients with diabetes than in patients with renal impairment from other causes [20]. The etiology of anemia in diabetes is multifactorial and includes inflammation, nutritional deficiencies, autoimmune diseases, hormonal changes, drugs in addition to kidney disease [19]. Anemia is found to contribute to the development and progression of diabetic complications which has a negative impact on the quality of life and an additional burden on the health of these patients [20].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Interrelationship Between Electrolytes, Anemia, and Glycosylated Hemoglobin (Hba1c) Levels in Type 2 Diabetics

Rajagopal

Ganesan

Abdullah

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The aim of this study is to analyze the interrelationship and pattern of electrolyte imbalance and compare the correlation between serum electrolytes, glycosylated hemoglobin (HbA1C), and hemoglobin (Hb) levels between Type 2 diabetic patients and non-diabetic subjects. Methods:This study was conducted in 300 subjects (150 diabetics and 150 non-diabetics) and further categorized as anemic and non-anemic within each group. Blood samples were analyzed for HbA1C, hemoglobin, and serum electrolyte levels.Results: Sodium (Na + ) levels in diabetics were significantly lower and potassium (K + ) as well as chloride (Cl − ) levels were significantly higher, when compared with non-diabetics. A significant positive correlation between HbA1C and potassium as well as chloride levels in contrast to negative correlation with sodium levels was observed in both genders. Among diabetics with anemia, we found significantly lower sodium and higher potassium and chloride. Conclusion:In diabetics, levels of sodium were significantly lower, and potassium as well as chloride was significantly higher when compared with non-diabetics. Our study clearly demonstrates an association between electrolytes, hemoglobin, and HbA1C levels in diabetes. This insight should pave the way for pathophysiology-directed therapy, thus contributing to the avoidance of several deleterious effects associated with electrolyte disorders and their treatment.

show abstract

Association of anemia and renal function test among diabetes mellitus patients attending Fenote Selam Hospital, West Gojam, Northwest Ethiopia: a cross sectional study

Cited by 35 publications

References 15 publications

Study of Osmotic Fragility Status of Red Blood Cell in Type II Diabetes Mellitus Patients

Study of Osmotic Fragility Status of Red Blood Cell in Type II Diabetes Mellitus Patients

Anemia in Patients with Diabetes Mellitus: Prevalence and Progression

Exploring the Interrelationship Between Electrolytes, Anemia, and Glycosylated Hemoglobin (Hba1c) Levels in Type 2 Diabetics

Contact Info

Product

Resources

About