Association between urine metals and liver function biomarkers in Northeast China: A cross-sectional study

Zhao, Man; Ge, Xiaoyu; Xu, Jing; Li, Ang; Mei, Yayuan; Yin, Guohuan; Wu, Jing; Liu, Xiaolin; Wei, Lanping; Xu, Qun

doi:10.1016/j.ecoenv.2022.113163

Cited by 33 publications

(20 citation statements)

References 80 publications

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“…. (18). The biological mechanisms explaining associations between urinary elements and serum albumin are not well-understood.…”

Section: Interpretation Of Resultsmentioning

confidence: 99%

“…Similarly, a cross-sectional study of 240 male tannery workers reported that prolonged exposure to hexavalent Cr (Mean: 4.89 μg/L in smokers) is likely to reduce serum albumin levels ( 21 ). Another cross-sectional study of 1,171 participants living in northeast China demonstrated that negative association between urinary Cr (Median: 4.41 μg/L) and serum albumin ( 18 ). The biological mechanisms explaining associations between urinary elements and serum albumin are not well-understood.…”

Section: Discussionmentioning

confidence: 99%

“…A disturbance in the delicate balance of essential nutrients can also negatively impact health ( 15 ). Consequently, essential and non-essential elements were linked with many adverse health effects, including low serum albumin levels ( 16 – 18 ). Experimental studies have suggested that metal ions, including cobalt (Co), chromium (Cr), and nickel (Ni) induce aggregation synergistically of human serum albumin ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

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The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

Zhou

Mei

et al. 2022

Front. Nutr.

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Background & aimsFew epidemiological studies have investigated the relationships of urinary essential and non-essential elements with serum albumin, an indicator of nutritional status, especially for the elderly in China.MethodsA community-based study among elderly participants (n = 275) was conducted in Beijing from November to December 2016. We measured 15 urinary elements concentrations and serum albumin levels. Three statistical methods including the generalized linear model (GLM), quantile g-computation model (qgcomp) and bayesian kernel machine regression (BKMR) were adapted.ResultsIn GLM analysis, we observed decreased serum albumin levels associated with elevated urinary concentrations of aluminum, arsenic, barium, cobalt, chromium, copper, iron, manganese, selenium, strontium, and zinc. Compared with the lowest tertile, the highest tertile of cadmium and cesium was also negatively associated with serum albumin. Urinary selenium concentration had the most significant negative contribution (30.05%) in the qgcomp analysis. The negative correlations of element mixtures with serum albumin were also observed in BKMR analysis.ConclusionsOur findings suggested the negative associations of essential and non-essential elements with serum albumin among the elderly. Large-scare cohort studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms.

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“…. (18). The biological mechanisms explaining associations between urinary elements and serum albumin are not well-understood.…”

Section: Interpretation Of Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

Zhou

Mei

et al. 2022

Front. Nutr.

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“…To reveal epigenome-wide DNA methylation patterns in response to Cr exposure, a cross-sectional study was conducted in Taihe district, Jinzhou City, Liaoning Province of northeast China, which experienced severe Cr pollution in the 1960s ( Zhao et al, 2022 ). Because of the large-scale production of ferroalloys, large amounts of wastewater, ore residue, and gas containing Cr (VI) were discharged into the environment surrounding Taihe district.…”

Section: Methodsmentioning

confidence: 99%

Association of environmental exposure to chromium with differential DNA methylation: An epigenome-wide study

Zhao

et al. 2023

Front. Genet.

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Introduction: Previous studies have reported that chromium (Cr)-induced epigenetic alterations and DNA methylation play a vital role in the pathogenesis of diseases induced by chromium exposure. Epigenomic analyses have been limited and mainly focused on occupational chromium exposure; their findings are not generalizable to populations with environmental Cr exposure.Methods: We identified the differential methylation of genes and regions to elucidate the mechanisms of toxicity related to environmental chromium exposure. DNA methylation was measured in blood samples collected from individuals in Cr-contaminated (n = 10) and unexposed areas (n = 10) by using the Illumina Infinium HumanMethylation850K array. To evaluate the relationship between chromium levels in urine and CpG methylation at 850 thousand sites, we investigated differentially methylated positions (DMPs) and differentially methylated regions (DMRs) by using linear models and DMRcate method, respectively. The model was adjusted for biologically relevant variables and estimated cell-type compositions.Results: At the epigenome-wide level, we identified five CpGs [cg20690919 (pFDR =0.006), cg00704664 (pFDR =0.024), cg10809143 (pFDR =0.043), cg27057652 (pFDR =0.047), cg05390480 (pFDR =0.024)] and one DMR (chr17: 19,648,718-19,648,972), annotated to ALDH3A1 genes (p < 0.05) as being significantly associated with log2 transformed urinary chromium levels.Discussion: Environmental chromium exposure is associated with DNA methylation, and the significant DMPs and DMR being annotated to cause DNA damage and genomic instability were found in this work. Research involving larger samples is required to further explore the epigenetic effect of environmental chromium exposure on health outcomes through DNA methylation.

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“…Aminotransferases are the most widely used biomarkers in experiments, and are released into the bloodstream following liver injury ( 89 ). Epidemiological studies have shown that BPA exposure could have negative effects on NAFLD-related biomarkers ( Table 5 ).…”

Section: Relationship Between Nafld and Edcsmentioning

confidence: 99%

Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease

Chen

Wang

Cui

et al. 2023

Front. Public Health

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Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder. With the improvement in human living standards, the prevalence of NAFLD has been increasing in recent years. Endocrine-disrupting chemicals (EDCs) are a class of exogenous chemicals that simulate the effects of hormones in the body. There has been growing evidence regarding the potential effects of EDCs on liver health, especially in NAFLD. This paper aims to summarize the major EDCs that contribute to the growing burden of NAFLD and to raise public awareness regarding the hazards posed by EDCs with the objective of reducing the incidence of NAFLD.

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Association between urine metals and liver function biomarkers in Northeast China: A cross-sectional study

Cited by 33 publications

References 80 publications

The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

Association of environmental exposure to chromium with differential DNA methylation: An epigenome-wide study

Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease

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