Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder. With the improvement in human living standards, the prevalence of NAFLD has been increasing in recent years. Endocrine-disrupting chemicals (EDCs) are a class of exogenous chemicals that simulate the effects of hormones in the body. There has been growing evidence regarding the potential effects of EDCs on liver health, especially in NAFLD. This paper aims to summarize the major EDCs that contribute to the growing burden of NAFLD and to raise public awareness regarding the hazards posed by EDCs with the objective of reducing the incidence of NAFLD.

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

“…NAFLD is recognized as the most prevalent liver disorder worldwide, affecting approximately 32% of the global population [ 92 ]. The crucial role of environmental pollutants, particularly endocrine disruptors, in the development of NAFLD has been acknowledged [ 93 , 94 ].…”

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

“…80 Series of studies have demonstrated the relationship between endocrine disruptors like bisphenol A and liver diseases like NAFLD development. 81 Suspected risk of NAFLD is found to be higher in people with higher quartiles of BPA exposure. 82 Nicolucci et al detected BPA above the normal limits in all patient samples (urine and plasma) with early and advanced liver diseases thus confirming an association between status of liver health and BPA exposure.…”

“…The mortality rates in case of fatty liver along with type 2 diabetes are extremely high in comparison to cardiovascular disease alone 80 . Series of studies have demonstrated the relationship between endocrine disruptors like bisphenol A and liver diseases like NAFLD development 81 . Suspected risk of NAFLD is found to be higher in people with higher quartiles of BPA exposure 82 .…”

Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD)

“…PCBs also differentially regulate hepatic lipid metabolism and several related genes. Exposure to PCBs increases liver lipids and causes steatosis associated with toxic substances (mild small-droplet macro-vesicular steatosis) [ 78 , 79 ]. Positive associations have also been observed between PCB concentrations and NAFLD-related biomarkers, with most PCB congeners positively correlating with elevated ALT levels.…”