Association between Serum Vitamin B12 Levels and the Degree of Steatosis in Patients with Nonalcoholic Fatty Liver Disease

Koplay, Mustafa; Gülcan, Erim; Özkan, Fuat

doi:10.2310/jim.0b013e31822a29f5

Cited by 53 publications

(43 citation statements)

References 18 publications

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“…As in humans with NAHLD [124], plasma cobalamin concentrations in cats with FHL were lower than those of healthy control cats [12]. Cobalamin is necessary for the synthesis of methionine from homocysteine, an essential reaction when methionine intake is diminished by starvation, as occurs in FHL.…”

Section: Implications For Feline Health—feline Hepatic Lipidosismentioning

confidence: 99%

Peculiarities of One-Carbon Metabolism in the Strict Carnivorous Cat and the Role in Feline Hepatic Lipidosis

Verbrugghe

Bakovic

2013

Nutrients

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Research in various species has indicated that diets deficient in labile methyl groups (methionine, choline, betaine, folate) produce fatty liver and links to steatosis and metabolic syndrome, but also provides evidence of the importance of labile methyl group balance to maintain normal liver function. Cats, being obligate carnivores, rely on nutrients in animal tissues and have, due to evolutionary pressure, developed several physiological and metabolic adaptations, including a number of peculiarities in protein and fat metabolism. This has led to specific and unique nutritional requirements. Adult cats require more dietary protein than omnivorous species, maintain a consistently high rate of protein oxidation and gluconeogenesis and are unable to adapt to reduced protein intake. Furthermore, cats have a higher requirement for essential amino acids and essential fatty acids. Hastened use coupled with an inability to conserve certain amino acids, including methionine, cysteine, taurine and arginine, necessitates a higher dietary intake for cats compared to most other species. Cats also seemingly require higher amounts of several B-vitamins compared to other species and are predisposed to depletion during prolonged inappetance. This carnivorous uniqueness makes cats more susceptible to hepatic lipidosis.

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Section: Implications For Feline Health—feline Hepatic Lipidosismentioning

confidence: 99%

Peculiarities of One-Carbon Metabolism in the Strict Carnivorous Cat and the Role in Feline Hepatic Lipidosis

Verbrugghe

Bakovic

2013

Nutrients

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“…Fatty liver disease (FLD) is a spectrum of clinical and pathological conditions that is due to the deposition of fat droplets in the liver of patients who have no history of alcohol consumption, it is determined and includes a range of diseases simple steatos to liver disease such as non-alcoholic steatohepatitis, fibrosis, cirrhosis and eventually hepatocellular cancers [1,2]. The natural liver contains 5 g of fat per 100 g of his weight, and if the fat content is more than 5 to 10 percent of the liver's weight, the person has a FLD (3).…”

Section: Introductionmentioning

confidence: 99%

Association between serum folate levels and fatty liver disease

Vahedi

Bavafaetousi

Zolfaghari

et al. 2020

Clinical Nutrition Experimental

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s u m m a r yBackground: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Due to the lack of definitive documentation for the effect of folic acid on fatty liver, this study was conducted to determine the relationship between serum folate levels and fatty liver in patients referred to Imam Hossain Hospital in Shahroud, in 2016. Methods: This caseecontrol study was performed on 150 patients. The case group was fatty liver patients whose disease was diagnosed based on laboratory and ultrasound findings and a control group of patients without fatty liver. After liver ultrasonography, blood samples were taken from all patients and folic acid levels were measured. Results: Of the 150 patients examined, mean BMI of patients was (25.3 ± 6.1 kg/m2 in case group and 24.8 ± 7.2 kg/m2 in control group), which was significantly higher in case group (p < 0.035). The mean fasting blood glucose level in patients was (137.5 ± 53.5 mg/dl in case group and 124.5 ± 62.5 mg/dl in control group), which was significantly higher in case group (p < 0.01). The mean LDL of the patients was (175.3 ± 65.5 mg/dl in case group and 125.5 ± 42.5 mg/dl in control group), which was significantly higher (P < 0.003) in patients with fatty liver. The mean of folic acid in patients was (3.7 ± 5.3 ng/ml in case group and 5.3 ± 4.1 ng/

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“…It is defined as accumulation of lipid deposits in the hepatocytes that are not due to excessive alcohol use [4] . NAFLD encompasses a spectrum of diseases ranging from simple fatty liver (hepatosteatosis) to nonalcoholic steatohepatitis (NASH), which in its most severe form can lead to liver fibrosis, cirrhosis and hepatocellular carcinoma [3,[5][6][7] . The pathophysiology of NAFLD has still not been exactly clarified.…”

Section: Introductionmentioning

confidence: 99%

“…The ''second hit'' leads to inflammation, hepatocyte injury and fibrosis. Oxidative stress, adipokines, proinflammatory cytokines and mitochondrial dysfunction are factors that induce the second hit [5,8,9] . However, there is growing evidence that this hypothesis is likely incorrect.…”

Section: Introductionmentioning

confidence: 99%

Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease

Koplay

Sivri

Erdoğan

et al. 2015

WJH

Self Cite

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease and is a major public health problem worldwide. It is a spectrum that includes simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Recently, NAFLD prevalence in children and adolescents has increased too. The increasing prevalence has resulted in NASH-related chronic liver disease. Therefore, early diagnosis and treatment is quite important. Although liver biopsy is still the gold standard for diagnosis and staging of NAFLD, particularly for the diagnosis of NASH, imaging methods such as ultrasonography, computed tomography, magnetic resonance imaging with chemical shift imaging and especially magnetic resonance spectroscopy and elastography have been increasingly approved as noninvasive alternative methods. The aim of this review is to analyze the diagnostic accuracy and limitations of the imaging methods and recent developments in the diagnosis of NAFLD.

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Association between Serum Vitamin B12 Levels and the Degree of Steatosis in Patients with Nonalcoholic Fatty Liver Disease

Abstract: The serum vitamin B12 levels were significantly lower in the patients with NAFLD than in those of the control group; however, these still remain in the reference range. Consequently, low vitamin B12 levels may be associated with NAFLD especially in grade 2 to grade 3 hepatosteatosis.

Cited by 53 publications

References 18 publications

Peculiarities of One-Carbon Metabolism in the Strict Carnivorous Cat and the Role in Feline Hepatic Lipidosis

Peculiarities of One-Carbon Metabolism in the Strict Carnivorous Cat and the Role in Feline Hepatic Lipidosis

Association between serum folate levels and fatty liver disease

Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease

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