Association between serum folate levels and fatty liver disease

Abstract

s u m m a r yBackground: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Due to the lack of definitive documentation for the effect of folic acid on fatty liver, this study was conducted to determine the relationship between serum folate levels and fatty liver in patients referred to Imam Hossain Hospital in Shahroud, in 2016. Methods: This caseecontrol study was performed on 150 patients. The case group was fatty liver patients whose disease was diagnosed based on laboratory and ultrasound findings and a control group of patients without fatty liver. After liver ultrasonography, blood samples were taken from all patients and folic acid levels were measured. Results: Of the 150 patients examined, mean BMI of patients was (25.3 ± 6.1 kg/m2 in case group and 24.8 ± 7.2 kg/m2 in control group), which was significantly higher in case group (p < 0.035). The mean fasting blood glucose level in patients was (137.5 ± 53.5 mg/dl in case group and 124.5 ± 62.5 mg/dl in control group), which was significantly higher in case group (p < 0.01). The mean LDL of the patients was (175.3 ± 65.5 mg/dl in case group and 125.5 ± 42.5 mg/dl in control group), which was significantly higher (P < 0.003) in patients with fatty liver. The mean of folic acid in patients was (3.7 ± 5.3 ng/ml in case group and 5.3 ± 4.1 ng/

Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation

“…Earlier studies showed that serum Hcy levels were positively associated with NAFLD, whereas serum B12 and Fol levels were negatively correlated with NAFLD/NASH severity [5][6][7][8]. Here, we showed conclusively that serum Hcy was positively correlated with NASH severity in patients, primates and mice.…”

“…[3,4]. Several recent clinical studies showed that serum Hcy levels were positively associated with NASH, and B12 and Fol levels were negatively correlated with NAFLD/NASH severity [5][6][7][8]. However, it is not known whether HHcy has a pathogenic role in NASH.…”

Persistent hypercobalaminemia three months after successful gradual attenuation of extrahepatic shunts in dogs: a prospective cohort study

“…Folate undergoes an enterohepatic cycle which is important for the folate homeostasis [32]. In people, folate deficiencies are seen in people with several chronic liver diseases [33,34]. Although serum folate concentrations remained within reference values, a significant increase was found between diagnosis and three months postoperatively.…”

Vitamins and Non Alcoholic Fatty Liver Disease

“…Çeşitli çalışmalarda serum folik asit seviyelerinin NAYKH hastalarında kontrollere kıyasla anlamlı şekilde düşük olduğu (44) ve düşük folik asit seviyelerinin fibroz derecesi ile ilişkili olduğu bulunmuştur (45). Yüksek yağlı diyet indüklü steatohepatit gelişen ratlarla yapılan bir çalışmada folik asit tedavisinin hepatik hücrelerde PPARα seviyelerini düzenleyerek hepatik lipid metabolizmasını iyileştirdiği, steatoz ve hepatoselüler hasarı hafiflettiği bildirilmiştir (46).…”