Association between serum cholesterol and serum organochlorine residues

Rashad, M. N.; Mi, M. P.; Klemmer, Howard W.; Budy, Ann M.; Reichert, Erida L.

doi:10.1007/bf01685075

Cited by 8 publications

(2 citation statements)

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“…Some authors have noted significantly elevated serum concentrations of cholesterol in pesticide-exposed workers (Wassermann 1970), while others have observed the same relationship of cholesterol to serum OCl's that has been revealed by our data (Rashad 1976). Substantial partial correlations with OCl's remain after the effects of age on both variables have been eliminated.…”

Section: Relationship Of Serum Cholesterol To Serum Ocl Concentrationssupporting

confidence: 77%

“…A difference in serum cholesterol related to serum [DDT + DDE] is borne out, particularly in the middle-age range. Thus, cholesterol differences appear to be associated more directly with serum OCl's, as observed by Rashad (1976), than with pesticide exposure, in general, as suggested by Wasserman (1970). A test for cholesterigenic effect that is available from our data utilized the contour of the serum cholesterol curve at extreme concentrations of OCI's.…”

Section: Relationship Of Serum Cholesterol To Serum Ocl Concentrationsmentioning

confidence: 70%

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Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides

Morgan

1978

Arch. Environ. Contam. Toxicol.

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Abstract. Organochlorine pesticide concentrations in blood and various clinical test variables were measured in 2,620 pesticide-exposed subjects and in 1,049 persons not occupationally exposed to pesticides. Differences in the pesticide contents of blood were identified in relation to geography, age, and occupational exposure. Analysis of hematologic and biochemical variables in terms of broad occupational categories revealed only very limited differences, but relationships of certain biochemical tests to serum organochlorine pesticide contents suggested subtle effects of these pesticides on liver function.Beginning in 1965, the U.S. Public Health Service established Community Studies in 14 states

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Section: Relationship Of Serum Cholesterol To Serum Ocl Concentrationssupporting

confidence: 77%

Section: Relationship Of Serum Cholesterol To Serum Ocl Concentrationsmentioning

confidence: 70%

Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides

Morgan

1978

Arch. Environ. Contam. Toxicol.

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Cross-sectional Study of a Community With Exceptional Exposure to DDT

Kreiss¹,

Zack²,

Kimbrough³

et al. 1981

JAMA

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The geometric mean level of total DDT in serum samples (76.2 ng/mL) from 499 persons living downstream from a defunct DDT-manufacturing plant was several times the national geometric mean (15.0 ng/mL). DDE isomers, metabolites of DDT, accounted for an average of 86.7% of total DDT. Total DDT levels increased with age, even when controlled for other independent variables also significantly associated with DDT: race, sex, fish consumption, years of residence, socioeconomic status, alcohol consumption, and serum triglyceride levels. Fish consumption, the second strongest determinant of DDT level, had one third the predictive power of age. Total DDT levels were not associated with specific illness or ill health. However, total DDT levels were positively associated with levels of serum cholesterol, triglyceride, and gamma-glutamyl transpeptidase. The finding that serum DDE levels increase with age suggests that no equilibrium in body burden has been reached or that pharmacokinetics or serum/adipose partition may vary with age.

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Clinical findings in workers exposed to pentachlorophenol

Klemmer

Wong

Sato

et al. 1980

Arch. Environ. Contam. Toxicol.

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Comparative findings are presented on the health and exposure status of groups of individuals in Hawaii with and without occupational exposure to pentachlorophenol (PCP). Occupational exposure to PCP occurred through employment at firms engaged in the treatment of wood with either PCP alone or PCP plus other compounds as preservative chemicals. Mean serum levels were 0.32 ppm for 32 control individuals, 1.72 ppm for 24 workers exposed to PCP and other wood preservative chemicals, and 3.78 ppm for 22 workers exposed to PCP as the sole preservative chemical. Age-standardized prevalence rates were significantly higher among the PCP-exposed than among the controls for low-grade infections or inflammations of the skin and subcutaneous tissue, protective membrane of the eyes and the mucosa membrane of the upper respiratory tract. Strong to moderate statistical associations were observed between PCP exposure and increased occurrence of bands (immature leucocytes) and basophils, increased plasma cholinesterase, alkaline phosphatase, gamma globulin and uric acid, and decreased serum calcium. Despite these statistical associations, laboratory values considered to be clinically abnormal were few and not significantly greater in occurrence among the PCP-exposed individuals.

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Association between serum cholesterol and serum organochlorine residues

Cited by 8 publications

References 0 publications

Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides

Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides

Cross-sectional Study of a Community With Exceptional Exposure to DDT

Clinical findings in workers exposed to pentachlorophenol

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